| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Madagascar: Escape 2 Africa | $266,603 | -48.2% | 29 | -36 | $9,193 | $2,545,488 | 3 | N/A | false | false |
| 2 | 2 | Body of Lies | $169,591 | -43.8% | 32 | - | $5,299 | $556,663 | 2 | N/A | false | false |
| 3 | - | Four Christmases | $164,217 | - | 26 | - | $6,316 | $164,217 | 1 | N/A | true | false |
| 4 | - | Quarantine | $154,433 | - | 21 | - | $7,353 | $154,433 | 1 | N/A | true | false |
| 5 | 3 | Beverly Hills Chihuahua | $129,125 | -45.3% | 31 | - | $4,165 | $458,927 | 2 | N/A | false | false |
| 6 | - | City of Ember | $89,751 | - | 16 | - | $5,609 | $122,241 | 1 | N/A | true | false |
| 7 | 4 | Quantum of Solace | $74,868 | -55.7% | 24 | -19 | $3,119 | $2,402,410 | 4 | N/A | false | false |
| 8 | - | Cape No. 7 | $71,767 | - | 12 | - | $5,980 | $84,905 | 1 | N/A | true | false |
| 9 | - | Wild Child | $63,807 | - | 15 | - | $4,253 | $77,900 | 1 | N/A | true | false |
| 10 | 5 | Winx Club: The Secret of the Lost Kingdom | $36,176 | -33.4% | 6 | -10 | $6,029 | $123,968 | 2 | N/A | false | false |
| 11 | - | KM 31: Kilometre 31 | $27,461 | - | 4 | - | $6,865 | $27,461 | 1 | N/A | true | false |
| 12 | - | Bolt | $23,730 | - | 1 | - | $23,730 | $23,730 | - | N/A | - | false |
| 13 | - | Zack and Miri Make a Porno | $10,043 | - | 4 | - | $2,510 | $10,043 | - | N/A | - | false |
| 14 | - | The Sky Crawlers | $9,137 | - | 3 | - | $3,045 | $9,137 | 1 | N/A | true | false |
| 15 | 7 | High School Musical 3: Senior Year | $6,149 | -59.6% | 9 | -7 | $683 | $1,554,970 | 6 | N/A | false | false |
| 16 | 10 | REC | $5,255 | -60.1% | 4 | -3 | $1,313 | $162,289 | 5 | N/A | false | false |
| 17 | 15 | Sing to the Dawn | $2,626 | -21.9% | 3 | -2 | $875 | $183,749 | 5 | N/A | false | false |
| 18 | - | The Secret Life of Bees | $801 | - | 1 | - | $801 | $801 | - | N/A | - | false |
