| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | High School Musical 3: Senior Year | $496,677 | - | 62 | - | $8,010 | $496,677 | 1 | N/A | true | false |
| 2 | 1 | Beverly Hills Chihuahua | $191,524 | +7.4% | 39 | +1 | $4,910 | $1,053,038 | 3 | N/A | false | false |
| 3 | - | Awake | $144,555 | - | 22 | - | $6,570 | $157,848 | 1 | N/A | true | false |
| 4 | 2 | Death Race | $112,146 | +23% | 38 | +5 | $2,951 | $326,507 | 2 | N/A | false | false |
| 5 | 4 | Mirrors | $76,104 | +11.3% | 21 | -4 | $3,624 | $936,078 | 5 | N/A | false | false |
| 6 | 3 | Babylon A.D. | $67,355 | -20.3% | 27 | -14 | $2,494 | $627,511 | 3 | N/A | false | false |
| 7 | - | Before the Devil Knows You're Dead | $64,445 | - | 24 | - | $2,685 | $72,837 | 1 | N/A | true | false |
| 8 | - | Blindness | $55,391 | - | 15 | - | $3,692 | $64,214 | 1 | N/A | true | false |
| 9 | 7 | The Boy in the Striped Pajamas | $35,526 | +23.5% | 12 | +1 | $2,960 | $102,983 | 2 | N/A | false | false |
| 10 | 5 | Forgetting Sarah Marshall | $33,347 | -27.5% | 25 | +2 | $1,333 | $556,211 | 4 | N/A | false | false |
| 11 | 9 | Space Chimps | $29,096 | +20.4% | 19 | +4 | $1,531 | $379,069 | 4 | N/A | false | false |
| 12 | 6 | Saw V | $20,734 | -50.6% | 15 | -16 | $1,382 | $1,382,326 | 6 | N/A | false | false |
| 13 | 8 | Highlander: The Source | $17,343 | -29.2% | 14 | - | $1,238 | $73,591 | 2 | N/A | false | false |
| 14 | 14 | The Hitcher | $16,641 | +31.3% | 8 | - | $2,080 | $157,986 | 3 | N/A | false | false |
| 15 | 11 | Journey to the Center of the Earth | $15,610 | -27.8% | 11 | -17 | $1,419 | $2,082,276 | 10 | N/A | false | false |
| 16 | 10 | Mamma Mia! | $12,790 | -46.2% | 15 | -10 | $852 | $766,381 | 6 | N/A | false | false |
| 17 | 17 | Lovewrecked | $10,589 | +31% | 8 | +1 | $1,323 | $282,285 | 7 | N/A | false | false |
| 18 | 15 | 3:10 to Yuma | $5,231 | -43.5% | 3 | -7 | $1,743 | $227,454 | 4 | N/A | false | false |
| 19 | 13 | The Forbidden Kingdom | $5,128 | -69.2% | 8 | -6 | $641 | $408,202 | 5 | N/A | false | false |
| 20 | 22 | La Virgen Negra | $4,285 | +73.8% | 4 | -1 | $1,071 | $239,966 | 6 | N/A | false | false |
| 21 | 19 | Shortbus | $3,182 | -45.5% | 2 | -6 | $1,591 | $50,411 | 3 | N/A | false | false |
| 22 | 12 | Lakeview Terrace | $2,647 | -87.7% | 4 | -18 | $661 | $249,688 | 4 | N/A | false | false |
| 23 | 23 | The House Bunny | $2,342 | +44.9% | 1 | -2 | $2,342 | $672,810 | 9 | N/A | false | false |
| 24 | 21 | Elsa & Fred | $2,156 | -39.4% | 2 | -2 | $1,078 | $87,799 | 7 | N/A | false | false |
| 25 | 18 | We Own the Night | $1,699 | -73.6% | 3 | -7 | $566 | $132,515 | 5 | N/A | false | false |
| 26 | 20 | Tropic Thunder | $1,366 | -72% | 4 | -7 | $341 | $718,952 | 7 | N/A | false | false |
