| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Bolt | $586,522 | - | 51 | - | $11,500 | $623,401 | 1 | N/A | true | false |
| 2 | 3 | Four Christmases | $113,881 | -30.7% | 26 | - | $4,380 | $332,526 | 2 | N/A | false | false |
| 3 | 1 | Madagascar: Escape 2 Africa | $92,035 | -65.5% | 27 | -2 | $3,408 | $2,628,391 | 4 | N/A | false | false |
| 4 | 4 | Quarantine | $85,966 | -44.3% | 21 | - | $4,093 | $282,534 | 2 | N/A | false | false |
| 5 | 2 | Body of Lies | $69,016 | -59.3% | 27 | -5 | $2,556 | $653,455 | 3 | N/A | false | false |
| 6 | 8 | Cape No. 7 | $60,466 | -15.7% | 12 | - | $5,038 | $167,964 | 2 | N/A | false | false |
| 7 | - | Beast Stalker | $56,039 | - | 11 | - | $5,094 | $56,039 | 1 | N/A | true | false |
| 8 | 6 | City of Ember | $50,733 | -43.5% | 16 | - | $3,170 | $200,648 | 2 | N/A | false | false |
| 9 | - | Zack and Miri Make a Porno | $41,760 | - | 4 | - | $10,440 | $56,431 | 1 | N/A | true | false |
| 10 | 9 | Wild Child | $30,779 | -51.8% | 15 | - | $2,051 | $143,016 | 2 | N/A | false | false |
| 11 | - | Sex Drive | $27,433 | - | 7 | - | $3,919 | $29,867 | 1 | N/A | true | false |
| 12 | 7 | Quantum of Solace | $27,392 | -63.4% | 12 | -12 | $2,282 | $2,449,486 | 5 | N/A | false | false |
| 13 | 5 | Beverly Hills Chihuahua | $24,962 | -80.7% | 26 | -5 | $960 | $515,701 | 3 | N/A | false | false |
| 14 | 11 | KM 31: Kilometre 31 | $21,409 | -22% | 4 | - | $5,352 | $57,816 | 2 | N/A | false | false |
| 15 | 10 | Winx Club: The Secret of the Lost Kingdom | $16,894 | -53.3% | 12 | +6 | $1,407 | $151,999 | 3 | N/A | false | false |
| 16 | 14 | The Sky Crawlers | $5,584 | -38.9% | 3 | - | $1,861 | $17,546 | 2 | N/A | false | false |
| 17 | - | The Secret Life of Bees | $4,195 | - | 1 | - | $4,195 | $4,969 | 1 | N/A | true | false |
| 18 | 16 | REC | $1,397 | -73.4% | 2 | -2 | $698 | $159,724 | 6 | N/A | false | false |
| 19 | 17 | Sing to the Dawn | $505 | -80.8% | 3 | - | $168 | $178,965 | 6 | N/A | false | false |
