| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Madagascar: Escape 2 Africa | $320,333 | - | 104 | - | $3,080 | $320,333 | 1 | United International Pictures | true | false |
| 2 | 1 | Mr. Bones 2: Back from the Past | $319,825 | -48.9% | 110 | - | $2,907 | $1,182,574 | 2 | United International Pictures | false | false |
| 3 | 2 | Quantum of Solace | $135,189 | -46% | 91 | -1 | $1,485 | $1,275,898 | 3 | Ster-Kinekor Pictures | false | false |
| 4 | - | The Women | $82,714 | - | 42 | - | $1,969 | $82,714 | 1 | Ster-Kinekor Pictures | true | false |
| 5 | 3 | High School Musical 3: Senior Year | $36,877 | -41.7% | 73 | -3 | $505 | $1,135,863 | 6 | Ster-Kinekor Pictures | false | false |
| 6 | 4 | Wild Child | $35,004 | -26.1% | 45 | - | $777 | $262,650 | 4 | United International Pictures | false | false |
| 7 | 5 | Body of Lies | $26,862 | -28.6% | 42 | -9 | $639 | $363,133 | 5 | NuMetro Distribution | false | false |
| 8 | 6 | Disaster Movie | $17,580 | -45.2% | 35 | -8 | $502 | $237,248 | 5 | United International Pictures | false | false |
| 9 | 8 | Friendship | $9,946 | -36.6% | 5 | - | $1,989 | $83,192 | 4 | NuMetro Distribution | false | false |
| 10 | 7 | Nights in Rodanthe | $9,457 | -58.5% | 22 | -21 | $429 | $348,445 | 6 | NuMetro Distribution | false | false |
| 11 | 9 | Max Payne | $7,688 | -47.1% | 19 | -13 | $404 | $398,786 | 7 | NuMetro Distribution | false | false |
| 12 | 10 | Death Race | $7,639 | -38.3% | 21 | -5 | $363 | $203,090 | 6 | United International Pictures | false | false |
| 13 | 12 | My Best Friend's Girl | $6,217 | -39.1% | 11 | -9 | $565 | $532,906 | 10 | NuMetro Distribution | false | false |
| 14 | - | The Boy in the Striped Pajamas | $5,312 | - | 5 | - | $1,062 | $5,312 | 1 | Ster-Kinekor Pictures | true | false |
| 15 | - | Religulous | $5,251 | - | 8 | - | $656 | $5,251 | 1 | NuMetro Distribution | true | false |
| 16 | 18 | The Counterfeiters | $3,928 | -21% | 4 | - | $982 | $41,459 | 5 | Ster-Kinekor Pictures | false | false |
| 17 | 11 | Beverly Hills Chihuahua | $3,705 | -64.9% | 16 | -9 | $231 | $382,732 | 10 | Ster-Kinekor Pictures | false | false |
| 18 | 17 | The Stone Angel | $3,194 | -46.8% | 7 | - | $456 | $14,827 | 2 | Ster-Kinekor Pictures | false | false |
| 19 | 19 | Lakeview Terrace | $2,953 | -39.1% | 6 | -3 | $492 | $111,938 | 7 | Ster-Kinekor Pictures | false | false |
| 20 | 14 | Quarantine | $2,829 | -55.7% | 10 | -3 | $282 | $39,608 | 4 | Ster-Kinekor Pictures | false | false |
| 21 | 20 | Righteous Kill | $2,146 | -53.2% | 4 | -3 | $536 | $173,488 | 8 | NuMetro Distribution | false | false |
| 22 | 16 | Yuvvraaj | $1,828 | -69.7% | 5 | -2 | $365 | $24,813 | 3 | NuMetro Distribution | false | false |
| 23 | 25 | Fugitive Pieces | $1,084 | -39.5% | 2 | - | $542 | $12,433 | 6 | United International Pictures | false | false |
| 24 | 26 | Pineapple Express | $488 | -13.3% | 1 | -1 | $488 | $32,264 | 6 | Ster-Kinekor Pictures | false | false |
| 25 | 28 | The House Bunny | $347 | -13.5% | 1 | -1 | $347 | $408,418 | 11 | Ster-Kinekor Pictures | false | false |
| 26 | 27 | Step Brothers | $337 | -32.3% | 1 | -1 | $337 | $40,629 | 9 | Ster-Kinekor Pictures | false | false |
| 27 | - | Flashbacks of a Fool | $228 | - | 1 | - | $228 | $5,413 | 4 | United International Pictures | false | false |
