| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Madagascar: Escape 2 Africa | $601,781 | -28.5% | 115 | - | $5,232 | $2,327,708 | 2 | Universal Pictures International (UPI) | false | false |
| 2 | - | The Day the Earth Stood Still | $506,752 | - | 85 | - | $5,961 | $506,752 | 1 | 20th Century Fox International | true | false |
| 3 | - | Burn After Reading | $274,300 | - | 32 | - | $8,571 | $359,415 | 1 | Universal Pictures International (UPI) | true | false |
| 4 | - | Transporter 3 | $250,032 | - | 28 | - | $8,929 | $268,823 | 1 | Belga Films | true | false |
| 5 | 2 | Loft | $243,585 | -18.7% | 29 | -293 | $8,399 | $6,768,270 | 8 | Independent Films | false | false |
| 6 | 3 | Twilight | $172,260 | -26.4% | 54 | - | $3,190 | $840,642 | 3 | Belga Films | false | false |
| 7 | 4 | Quantum of Solace | $93,564 | -46% | 83 | -13 | $1,127 | $4,444,229 | 6 | Sony Pictures Releasing | false | false |
| 8 | - | Piet Piraat en het zwaard van Zilvertand | $63,375 | - | 32 | - | $1,980 | $75,149 | 1 | Kinepolis Film Distribution (KFD) | true | false |
| 9 | 7 | Agathe Cléry | $45,809 | -45% | 13 | - | $3,523 | $149,968 | 2 | Alternative Films | false | false |
| 10 | 6 | Changeling | $43,719 | -47.8% | 28 | -5 | $1,561 | $772,304 | 5 | Universal Pictures International (UPI) | false | false |
| 11 | 5 | Body of Lies | $36,364 | -66.4% | 35 | -15 | $1,038 | $719,759 | 4 | Warner Bros. | false | false |
| 12 | - | A Pain in the Ass | $33,608 | - | 22 | - | $1,527 | $35,052 | 1 | Benelux Film Distributors | true | false |
| 13 | 9 | A.R.O.G | $33,237 | -59% | 6 | +1 | $5,539 | $145,001 | 2 | Maxximum Film und Kunst GmbH | false | false |
| 14 | 11 | Winter in Wartime | $31,860 | -37.5% | 15 | - | $2,124 | $98,489 | 2 | Benelux Film Distributors | false | false |
| 15 | 12 | High School Musical 3: Senior Year | $30,265 | -30.1% | 36 | -25 | $840 | $2,348,810 | 7 | Walt Disney Pictures | false | false |
| 16 | 10 | Pride and Glory | $27,474 | -61.5% | 19 | - | $1,446 | $117,825 | 2 | Kinepolis Film Distribution (KFD) | false | false |
| 17 | 16 | Vicky Cristina Barcelona | $21,896 | -35.8% | 13 | -7 | $1,684 | $941,184 | 7 | Cinéart | false | false |
| 18 | 8 | Max Payne | $21,178 | -74.4% | 25 | -8 | $847 | $306,928 | 3 | 20th Century Fox International | false | false |
| 19 | 20 | Quiet Chaos | $15,800 | -9.7% | 10 | - | $1,580 | $45,738 | 2 | Cinéart | false | false |
| 20 | 15 | Public Enemy | $15,656 | -54.3% | 19 | - | $824 | $262,424 | 4 | Kinepolis Film Distribution (KFD) | false | false |
| 21 | 13 | The Bank Job | $11,762 | -68.3% | 15 | - | $784 | $134,168 | 3 | Benelux Film Distributors | false | false |
| 22 | - | Lakeview Terrace | $10,150 | - | 3 | - | $3,383 | $13,496 | 1 | Sony Pictures Releasing | true | false |
| 23 | 18 | Space Chimps | $9,531 | -54.6% | 22 | -21 | $433 | $1,186,778 | 8 | Belga Films | false | false |
| 24 | 14 | Quarantine | $9,284 | -74.4% | 9 | -4 | $1,031 | $100,120 | 2 | Sony Pictures Releasing | false | false |
| 25 | 17 | Le vilain | $9,010 | -59.3% | 9 | -3 | $1,001 | $223,905 | 5 | Victory Productions | false | false |
| 26 | 24 | The Class | $8,168 | -13.7% | 9 | -24 | $907 | $703,092 | 11 | Cinéart | false | false |
| 27 | 21 | Journey to the Center of the Earth | $7,560 | -55.7% | 4 | -7 | $1,890 | $246,700 | 5 | Warner Bros. | false | false |
| 28 | 25 | Anubis en het Pad der 7 Zonden | $7,310 | -18.8% | 14 | -11 | $522 | $1,302,240 | 9 | Kinepolis Film Distribution (KFD) | false | false |
| 29 | 22 | Musée haut, musée bas | $5,806 | -51% | 3 | -3 | $1,935 | $53,543 | 3 | Cinéart | false | false |
| 30 | 23 | Brideshead Revisited | $5,605 | -50.5% | 8 | -3 | $700 | $45,476 | 3 | Cinéart | false | false |
| 31 | 30 | Seraphine | $4,892 | -13.9% | 6 | - | $815 | $141,669 | 8 | Cinéart | false | false |
| 32 | 34 | Elegy | $3,560 | -4.4% | 7 | -3 | $508 | $146,412 | 8 | Kinepolis Film Distribution (KFD) | false | false |
| 33 | 19 | Nights in Rodanthe | $2,999 | -84.3% | 8 | -12 | $374 | $133,302 | 3 | Warner Bros. | false | false |
| 34 | 27 | Crime Is Our Business | $2,911 | -62.7% | 4 | -2 | $727 | $60,885 | 5 | Cinéart | false | false |
| 35 | 29 | Rachel Getting Married | $2,671 | -54.3% | 2 | - | $1,335 | $22,875 | 3 | Sony Pictures Releasing | false | false |
| 36 | - | Salt of This Sea | $2,617 | - | 6 | - | $436 | $5,220 | 1 | N/A | true | false |
| 37 | 32 | Nowhere Man | $2,174 | -45% | 5 | -2 | $434 | $22,119 | 3 | Kinepolis Film Distribution (KFD) | false | false |
| 38 | 33 | RocknRolla | $2,072 | -46% | 1 | -2 | $2,072 | $72,163 | 4 | Universal Pictures International (UPI) | false | false |
| 39 | 35 | Welcome to the Sticks | $2,028 | -45.5% | 7 | -1 | $289 | $10,631,400 | 42 | Alternative Films | false | false |
| 40 | 53 | A French Gigolo | $1,615 | +140.3% | 2 | - | $807 | $167,738 | 10 | Benelux Film Distributors | false | false |
| 41 | 57 | The Zone | $1,469 | +476.1% | 2 | +1 | $734 | $62,161 | 12 | Paradiso Entertainment | false | false |
| 42 | 36 | Modern Life | $1,449 | -56% | 2 | - | $724 | $25,274 | 6 | Benelux Film Distributors | false | false |
| 43 | 39 | Mamma Mia! | $1,346 | -55.2% | 11 | -7 | $122 | $3,476,898 | 14 | Universal Pictures International (UPI) | false | false |
| 44 | 37 | The Accidental Husband | $1,335 | -59.4% | 2 | -1 | $667 | $359,967 | 6 | Belga Films | false | false |
| 45 | 45 | My Best Friend's Girl | $1,315 | -25.5% | 2 | +1 | $657 | $444,591 | 9 | Kinepolis Film Distribution (KFD) | false | false |
| 46 | 43 | The Edge of Love | $1,269 | -39.4% | 2 | - | $634 | $10,308 | 3 | Belga Films | false | false |
| 47 | 46 | WALL·E | $1,101 | -37.4% | 2 | -2 | $550 | $4,280,099 | 20 | Walt Disney Pictures | false | false |
| 48 | 28 | Sinterklaas en het geheim van het grote boek | $960 | -86.9% | 4 | -4 | $240 | $80,673 | 6 | Kinepolis Film Distribution (KFD) | false | false |
| 49 | 42 | Hunger | $840 | -61.5% | 5 | - | $168 | $27,639 | 5 | Paradiso Entertainment | false | false |
| 50 | 48 | Home | $832 | -48.4% | 6 | - | $138 | $45,068 | 5 | Benelux Film Distributors | false | false |
| 51 | 26 | The Ottoman Republic | $695 | -91.6% | 2 | -3 | $347 | $84,829 | 4 | Maxximum Film und Kunst GmbH | false | false |
| 52 | 31 | Mesrine: Killer Instinct | $666 | -88% | 2 | -10 | $333 | $523,283 | 8 | A-Film Distribution | false | false |
| 53 | 55 | Cut Loose | $420 | +3.2% | 5 | +1 | $84 | $607,290 | 13 | Kinepolis Film Distribution (KFD) | false | false |
| 54 | 51 | Happy-Go-Lucky | $291 | -67.7% | 2 | -4 | $145 | $216,731 | 16 | Kinepolis Film Distribution (KFD) | false | false |
| 55 | 56 | Moscow, Belgium | $284 | -2.1% | 3 | +1 | $94 | $1,871,556 | 46 | Kinepolis Film Distribution (KFD) | false | false |
| 56 | 58 | W. | $137 | -32.2% | 1 | - | $137 | $124,647 | 7 | Paradiso Entertainment | false | false |
| 57 | 54 | Blindness | $124 | -69.8% | 4 | -1 | $31 | $168,231 | 10 | Kinepolis Film Distribution (KFD) | false | false |
| 58 | 59 | The Wave | $62 | +14.8% | 1 | - | $62 | $42,706 | 8 | Paradiso Entertainment | false | false |
