| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | The Day the Earth Stood Still | $2,306,666 | - | 448 | - | $5,148 | $2,306,666 | 1 | 20th Century Fox International | true | false |
| 2 | - | As God Commands | $1,060,677 | - | 247 | - | $4,294 | $989,914 | 1 | 01 Distribution | true | false |
| 3 | 3 | Bolt | $818,920 | -36.2% | 416 | -31 | $1,968 | $6,114,244 | 3 | Walt Disney Pictures | false | false |
| 4 | 1 | Twilight | $781,143 | -47.9% | 285 | -119 | $2,740 | $14,547,559 | 4 | Eagle Pictures | false | false |
| 5 | 2 | Saw V | $595,148 | -54.9% | 272 | - | $2,188 | $2,894,519 | 2 | 01 Distribution | false | false |
| 6 | 5 | Just a Father | $428,466 | -27.5% | 212 | -2 | $2,021 | $2,630,249 | 3 | Warner Bros. | false | false |
| 7 | 4 | Body of Lies | $402,702 | -44.5% | 191 | -62 | $2,108 | $5,849,999 | 4 | Warner Bros. | false | false |
| 8 | 6 | Changeling | $318,668 | -38.3% | 185 | -37 | $1,722 | $6,655,592 | 5 | Universal Pictures International (UPI) | false | false |
| 9 | 11 | Slumdog Millionaire | $311,029 | -2.8% | 103 | -2 | $3,019 | $886,761 | 2 | Lucky Red | false | false |
| 10 | 7 | La fidanzata di papà | $292,360 | -36.2% | 126 | -54 | $2,320 | $9,455,868 | 5 | Medusa Distribuzione | false | false |
| 11 | 8 | I'll Be Back to Living Alone | $234,579 | -47.8% | 171 | -30 | $1,371 | $1,059,633 | 2 | Eagle Pictures | false | false |
| 12 | 9 | Never Back Down | $178,067 | -57.6% | 136 | -33 | $1,309 | $1,945,215 | 3 | Medusa Distribuzione | false | false |
| 13 | 12 | Passengers | $174,460 | -38.5% | 100 | -3 | $1,744 | $673,417 | 2 | Moviemax | false | false |
| 14 | 13 | Happy-Go-Lucky | $159,292 | -24.4% | 75 | +9 | $2,123 | $505,523 | 2 | Mikado Film | false | false |
| 15 | 14 | The Visitor | $127,447 | +3.7% | 38 | +15 | $3,353 | $338,374 | 2 | Bolero Film | false | false |
| 16 | 10 | Max Payne | $85,093 | -76.3% | 88 | -110 | $966 | $1,849,465 | 3 | 20th Century Fox International | false | false |
| 17 | 15 | We Can Do That | $77,662 | -31.8% | 58 | -5 | $1,339 | $2,073,781 | 7 | Warner Bros. | false | false |
| 18 | - | Lemon Tree | $52,899 | - | 10 | - | $5,289 | $52,899 | 1 | Teodora Film | true | false |
| 19 | 20 | A Christmas Tale | $44,495 | -21.5% | 38 | -1 | $1,170 | $147,666 | 2 | BIM Distribuzione | false | false |
| 20 | 19 | Welcome to the Sticks | $40,747 | -35.4% | 25 | -5 | $1,629 | $3,948,055 | 7 | Medusa Distribuzione | false | false |
| 21 | 16 | Ti stramo: Ho voglia di un'ultima notte da manuale prima di tre baci sopra il cielo | $35,575 | -58.2% | 28 | -31 | $1,270 | $567,450 | 3 | Mikado Film | false | false |
| 22 | 24 | Stella | $34,010 | +19.5% | 14 | +4 | $2,429 | $90,011 | 2 | Sacher Distribuzione | false | false |
| 23 | 26 | Death Race | $26,371 | +9.2% | 16 | +8 | $1,648 | $392,745 | 3 | Universal Pictures International (UPI) | false | false |
| 24 | 23 | Rachel Getting Married | $22,414 | -31.9% | 16 | -2 | $1,400 | $244,665 | 4 | Sony Pictures Releasing | false | false |
| 25 | 18 | Galantuomini | $22,187 | -65.7% | 29 | -23 | $765 | $721,083 | 4 | 01 Distribution | false | false |
| 26 | 25 | Mamma Mia! | $19,874 | -26% | 11 | -2 | $1,806 | $11,153,002 | 11 | United International Pictures | false | false |
| 27 | 17 | Quantum of Solace | $19,666 | -72.3% | 20 | -79 | $983 | $9,034,268 | 6 | Sony Pictures Releasing | false | false |
| 28 | 30 | WALL·E | $18,663 | +11.6% | 24 | -1 | $777 | $11,596,223 | 9 | Walt Disney Pictures | false | false |
| 29 | 33 | The Orphanage | $13,931 | -8.4% | 13 | -2 | $1,071 | $1,944,832 | 5 | Lucky Red | false | false |
| 30 | 28 | The Class | $13,425 | -41.5% | 13 | -3 | $1,032 | $2,165,295 | 10 | Mikado Film | false | false |
| 31 | 27 | Palermo Shooting | $13,211 | -43.6% | 13 | -5 | $1,016 | $151,593 | 3 | BIM Distribuzione | false | false |
| 32 | 31 | Vicky Cristina Barcelona | $12,895 | -20.2% | 13 | +2 | $991 | $7,789,220 | 9 | Medusa Distribuzione | false | false |
| 33 | 32 | High School Musical 3: Senior Year | $8,125 | -47.4% | 16 | -13 | $507 | $12,255,365 | 7 | Walt Disney Pictures | false | false |
| 34 | 35 | Mid-August Lunch | $7,006 | -24.6% | 6 | - | $1,167 | $2,798,054 | 15 | Fandango | false | false |
| 35 | 34 | The Burning Plain | $6,581 | -36.8% | 15 | +5 | $438 | $1,747,651 | 6 | Medusa Distribuzione | false | false |
| 36 | 38 | The Early Bird Catches the Worm | $6,564 | +40% | 2 | +1 | $3,282 | $1,501,443 | 42 | Medusa Distribuzione | false | false |
| 37 | 39 | The Man Who Loves | $6,101 | +34.7% | 8 | +2 | $762 | $1,835,746 | 8 | Medusa Distribuzione | false | false |
| 38 | - | Trick or Treaters | $3,757 | - | 12 | - | $313 | $120,432 | 6 | BIM Distribuzione | false | false |
| 39 | - | Stare fuori | $3,392 | - | 4 | - | $848 | $3,392 | 1 | - | true | false |
| 40 | 21 | Io non ci casco | $2,858 | -94.4% | 10 | -58 | $285 | $91,587 | 2 | Medusa Distribuzione | false | false |
| 41 | 44 | Burn After Reading | $2,684 | -9.2% | 2 | +1 | $1,342 | $8,162,187 | 13 | Medusa Distribuzione | false | false |
| 42 | 36 | Someone to Run With | $2,577 | -70.8% | 7 | +2 | $368 | $138,817 | 4 | Medusa Distribuzione | false | false |
| 43 | 48 | Giovanna's Father | $2,281 | +41.8% | 2 | +1 | $1,140 | $4,800,000 | 14 | Medusa Distribuzione | false | false |
| 44 | - | Awake | $2,128 | - | 3 | - | $709 | $924,096 | 5 | Eagle Pictures | false | false |
| 45 | - | Donkey Xote | $1,487 | - | 4 | - | $371 | $68,150 | 7 | N/A | false | false |
| 46 | - | One Day in a Life | $1,462 | - | 1 | - | $1,462 | $73,247 | 6 | Ripley's Film | false | false |
| 47 | 22 | The House Bunny | $1,439 | -96% | 9 | -26 | $159 | $52,446 | 2 | Sony Pictures Releasing | false | false |
| 48 | - | Control | $1,345 | - | 2 | - | $672 | $99,924 | 8 | Metacinema | false | false |
| 49 | 37 | The Past Is a Foreign Land | $1,284 | -75.6% | 4 | -3 | $321 | $965,171 | 7 | 01 Distribution | false | false |
| 50 | - | Ex Drummer | $1,177 | - | 1 | - | $1,177 | $59,679 | 11 | L'Altrofilm | false | false |
