| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Madagascar: Escape 2 Africa | $392,974 | -28.3% | 101 | -3 | $3,890 | $4,091,589 | 4 | Paramount Pictures International | false | false |
| 2 | 2 | Four Christmases | $100,922 | -8.8% | 40 | -1 | $2,523 | $234,954 | 2 | Distribution Company | false | false |
| 3 | 4 | Body of Lies | $92,311 | +18.5% | 45 | - | $2,051 | $776,286 | 5 | Warner Bros. | false | false |
| 4 | 3 | High School Musical 3: Senior Year | $65,323 | -28.1% | 113 | -2 | $578 | $1,233,369 | 5 | Walt Disney Pictures | false | false |
| 5 | 5 | Quarantine | $58,888 | +15.1% | 30 | - | $1,962 | $306,227 | 4 | Sony Pictures Releasing | false | false |
| 6 | 6 | The Duchess | $37,105 | -10.4% | 14 | - | $2,650 | $160,871 | 3 | United International Pictures | false | false |
| 7 | 8 | Righteous Kill | $32,022 | +24% | 40 | - | $800 | $533,068 | 6 | CDI Films | false | false |
| 8 | 9 | Death Sentence | $28,400 | +21.1% | 33 | - | $860 | $161,109 | 4 | Distribution Company | false | false |
| 9 | 12 | Quantum of Solace | $28,327 | +63.5% | 16 | +2 | $1,770 | $1,255,513 | 8 | Sony Pictures Releasing | false | false |
| 10 | 10 | Che: Part One | $21,422 | +16% | 28 | -6 | $765 | $637,963 | 7 | Alfa Films | false | false |
| 11 | 7 | Fly Me to the Moon 3D | $20,082 | -40% | 45 | - | $446 | $62,025 | 2 | Distribution Company | false | false |
| 12 | - | Bella | $18,275 | - | 8 | - | $2,284 | $18,275 | 1 | CDI Films | true | false |
| 13 | 11 | Planet Terror | $16,301 | -6.7% | 24 | - | $679 | $76,527 | 3 | Pachamama Cine | false | false |
| 14 | 13 | RocknRolla | $15,714 | -1.2% | 15 | +3 | $1,047 | $66,561 | 3 | Warner Bros. | false | false |
| 15 | 14 | Deception | $12,909 | -4.7% | 12 | -1 | $1,075 | $57,170 | 3 | Alfa Films | false | false |
| 16 | 18 | Flawless | $11,726 | +24.4% | 21 | -1 | $558 | $250,805 | 8 | Distribution Company | false | false |
| 17 | 21 | Death Defying Acts | $9,973 | +25.7% | 22 | - | $453 | $115,918 | 5 | Alfa Films | false | false |
| 18 | 15 | The Boy in the Striped Pajamas | $9,704 | -2.9% | 13 | - | $746 | $73,259 | 4 | Walt Disney Pictures | false | false |
| 19 | 17 | Ira & Abby | $9,302 | -2.1% | 13 | - | $715 | $39,831 | 3 | CDI Films | false | false |
| 20 | 16 | Saw V | $9,271 | -3.3% | 25 | -2 | $370 | $1,046,482 | 9 | Walt Disney Pictures | false | false |
| 21 | 19 | My Mom's New Boyfriend | $9,261 | -0.6% | 16 | - | $578 | $139,189 | 7 | - | false | false |
| 22 | 22 | The Bank Job | $7,300 | +8.9% | 25 | -1 | $292 | $624,054 | 11 | Alfa Films | false | false |
| 23 | 20 | Elegy | $7,062 | -20.7% | 20 | - | $353 | $168,378 | 6 | Distribution Company | false | false |
| 24 | 25 | Tear This Heart Out | $5,607 | -4.6% | 7 | - | $801 | $41,347 | 5 | 20th Century Fox International | false | false |
| 25 | 23 | Beverly Hills Chihuahua | $4,563 | -26.9% | 30 | +1 | $152 | $1,556,208 | 12 | Walt Disney Pictures | false | false |
| 26 | 24 | Max Payne | $4,078 | -31.3% | 25 | -1 | $163 | $166,107 | 6 | 20th Century Fox International | false | false |
| 27 | 27 | Red Like the Sky 2008 Re-release | $3,289 | -2.1% | 3 | - | $1,096 | $21,403 | 4 | Primer Plano Film Group | false | false |
| 28 | 26 | La leyenda | $2,014 | -53.3% | 15 | -8 | $134 | $218,060 | 6 | United International Pictures | false | false |
| 29 | 30 | Burn After Reading | $1,852 | +38.1% | 9 | +1 | $205 | $865,473 | 10 | United International Pictures | false | false |
| 30 | 28 | Fados | $1,549 | -51.2% | 6 | +2 | $258 | $31,378 | 5 | Distribution Company | false | false |
| 31 | 40 | Hellboy II: The Golden Army | $1,194 | +1,197.8% | 1 | - | $1,194 | $299,372 | 12 | United International Pictures | false | false |
| 32 | 29 | Black Christmas | $1,146 | -45.3% | 9 | - | $127 | $96,299 | 7 | Distribution Company | false | false |
| 33 | 32 | The Magic Flute | $777 | -2.6% | 5 | - | $155 | $26,425 | 10 | Distribution Company | false | false |
| 34 | 33 | Blindness | $575 | -1.2% | 5 | +1 | $115 | $190,174 | 9 | 20th Century Fox International | false | false |
| 35 | 36 | Nights in Rodanthe | $437 | +137.5% | 7 | +1 | $62 | $896,255 | 13 | Warner Bros. | false | false |
| 36 | 31 | Manual of Love 2008 Re-release | $265 | -71.4% | 4 | - | $66 | $134,860 | 14 | Notro Films | false | false |
| 37 | 41 | Mamma Mia! | $214 | +140.4% | 2 | +1 | $107 | $1,463,317 | 19 | United International Pictures | false | false |
| 38 | 42 | Camera Obscura 2008 Re-release | $209 | +198.6% | 2 | +1 | $104 | $65,989 | 11 | Distribution Company | false | false |
| 39 | 34 | Four Minutes | $160 | -52.5% | 1 | - | $160 | $161,337 | 18 | Alfa Films | false | false |
| 40 | 39 | Nos otros | $155 | +55% | 1 | - | $155 | $2,697 | 5 | CDI Films | false | false |
| 41 | 37 | My Brother is an Only Child | $59 | -60.1% | 1 | - | $59 | $226,504 | 15 | Alfa Films | false | false |
| 42 | 43 | Days of Darkness | $53 | -10.2% | 1 | - | $53 | $15,272 | 11 | Alfa Films | false | false |
| 43 | 35 | Shara | $27 | -85.6% | 1 | -1 | $27 | $43,786 | 9 | Zeta Films | false | false |
| 44 | 38 | Mirrors | $24 | -77.1% | 1 | - | $24 | $622,572 | 13 | 20th Century Fox International | false | false |
