| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Madagascar: Escape 2 Africa | $550,376 | +5.4% | 77 | +11 | $7,147 | $4,185,208 | 4 | N/A | false | false |
| 2 | 2 | Twilight | $307,665 | -2.6% | 62 | +2 | $4,962 | $1,520,402 | 3 | N/A | false | false |
| 3 | 3 | Bolt | $263,159 | -11.4% | 55 | +4 | $4,784 | $1,304,416 | 3 | N/A | false | false |
| 4 | 4 | Four Christmases | $242,598 | +0.1% | 35 | - | $6,931 | $733,095 | 2 | N/A | false | false |
| 5 | - | The Tale of Despereaux | $234,149 | - | 40 | - | $5,853 | $277,430 | 1 | N/A | true | false |
| 6 | - | Max Payne | $231,900 | - | 40 | - | $5,797 | $272,871 | 1 | N/A | true | false |
| 7 | 5 | The Day the Earth Stood Still | $207,922 | -7.8% | 57 | +2 | $3,647 | $1,954,482 | 4 | N/A | false | false |
| 8 | 6 | Australia | $157,282 | +12.7% | 52 | +9 | $3,024 | $467,664 | 2 | N/A | false | false |
| 9 | 7 | A mi me gusta | $71,636 | +57.3% | 17 | -1 | $4,213 | $318,291 | 4 | N/A | false | false |
| 10 | 11 | Awake | $20,937 | +11.9% | 7 | - | $2,991 | $689,916 | 6 | N/A | false | false |
| 11 | 9 | Quantum of Solace | $19,953 | -32.4% | 10 | - | $1,995 | $1,122,863 | 5 | N/A | false | false |
| 12 | 10 | High School Musical 3: Senior Year | $18,126 | -14.2% | 25 | - | $725 | $1,414,018 | 6 | N/A | false | false |
| 13 | 8 | Body of Lies | $17,244 | -55.4% | 12 | -1 | $1,437 | $538,469 | 4 | N/A | false | false |
| 14 | 13 | Caramel | $8,784 | +165.9% | 2 | -1 | $4,392 | $26,507 | 3 | N/A | false | false |
| 15 | 12 | The Boy in the Striped Pajamas | $6,764 | +3.1% | 3 | - | $2,254 | $199,320 | 7 | N/A | false | false |
| 16 | 14 | Beverly Hills Chihuahua | $6,660 | +167.1% | 10 | +3 | $666 | $1,409,573 | 8 | N/A | false | false |
| 17 | 15 | La Virgen Negra | $3,042 | +125.3% | 2 | - | $1,521 | $264,705 | 11 | N/A | false | false |
