| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Bedtime Stories | $1,421,902 | -41.3% | 600 | - | $2,369 | $5,807,956 | 2 | Walt Disney Pictures | false | false |
| 2 | - | Seven Pounds | $1,046,153 | - | 300 | - | $3,487 | $1,046,143 | 1 | Sony Pictures Releasing | true | false |
| 3 | 2 | Rudo y Cursi | $722,001 | -29.7% | 413 | -10 | $1,748 | $7,400,954 | 4 | Universal Pictures International (UPI) | false | false |
| 4 | 3 | Bolt | $480,522 | -45.5% | 503 | -130 | $955 | $7,030,858 | 4 | Walt Disney Pictures | false | false |
| 5 | 4 | Australia | $423,210 | -43.7% | 373 | -20 | $1,134 | $3,572,177 | 3 | 20th Century Fox International | false | false |
| 6 | 7 | Volverte a ver | $311,318 | -26.3% | 332 | -5 | $937 | $1,926,077 | 3 | Videocine | false | false |
| 7 | 5 | Madagascar: Escape 2 Africa | $301,256 | -54.5% | 383 | -43 | $786 | $16,113,658 | 6 | Paramount Pictures International | false | false |
| 8 | 6 | The Day the Earth Stood Still | $231,568 | -58.3% | 318 | -82 | $728 | $9,104,760 | 5 | 20th Century Fox International | false | false |
| 9 | - | The Flock | $176,959 | - | 120 | - | $1,474 | $179,255 | 1 | Videocine | true | false |
| 10 | 8 | The Tale of Despereaux | $163,346 | -59.6% | 358 | -56 | $456 | $2,228,280 | 3 | Universal Pictures International (UPI) | false | false |
| 11 | 18 | Solstice | $158,021 | +2,773.6% | 119 | +109 | $1,327 | $575,236 | 6 | Videocine | false | false |
| 12 | 9 | Four Christmases | $136,273 | -47.5% | 175 | -113 | $778 | $1,899,158 | 4 | Gussi Films | false | false |
| 13 | 10 | Twilight | $91,135 | -50% | 124 | -45 | $734 | $9,726,785 | 8 | Corazón Films | false | false |
| 14 | - | RocknRolla | $81,970 | - | 80 | - | $1,024 | $82,195 | 1 | Warner Bros. | true | false |
| 15 | - | Death Defying Acts | $63,699 | - | 77 | - | $827 | $472,538 | 8 | Gussi Films | false | false |
| 16 | 12 | Vicky Cristina Barcelona | $61,771 | +80.5% | 78 | +56 | $791 | $780,169 | 6 | Gussi Films | false | false |
| 17 | - | Penelope | $58,703 | - | 40 | - | $1,467 | $63,202 | 1 | Gussi Films | true | false |
| 18 | - | The Women | $57,888 | - | 70 | - | $826 | $392,840 | 7 | Universal Pictures International (UPI) | false | false |
| 19 | 19 | Disaster Movie | $55,713 | +1,569.6% | 64 | +56 | $870 | $639,672 | 7 | Gussi Films | false | false |
| 20 | 11 | The Boy in the Striped Pajamas | $38,189 | -13.1% | 33 | +9 | $1,157 | $532,366 | 7 | Walt Disney Pictures | false | false |
| 21 | - | The Edge of Heaven | $25,460 | - | 14 | - | $1,818 | $25,460 | 1 | Alphaville | true | false |
| 22 | 15 | The Duchess | $24,637 | +47.4% | 26 | +14 | $947 | $364,146 | 8 | Paramount Pictures International | false | false |
| 23 | - | Be Kind Rewind | $22,200 | - | 27 | - | $822 | $327,406 | 11 | Videocine | false | false |
| 24 | - | Appaloosa | $17,052 | - | 17 | - | $1,003 | $70,186 | 5 | Gussi Films | false | false |
| 25 | 14 | Saw V | $12,622 | -27.5% | 23 | - | $548 | $1,015,907 | 11 | Walt Disney Pictures | false | false |
| 26 | - | Mama's Boy | $11,676 | - | 16 | - | $729 | $94,931 | 5 | Videocine | false | false |
| 27 | - | Du jour au lendemain 2009 Re-release | $10,500 | - | 12 | - | $875 | $10,500 | 1 | Cinemas Nueva Era | true | false |
| 28 | - | Noodle | $8,318 | - | 8 | - | $1,039 | $62,487 | 3 | Zima Entertainment | false | false |
| 29 | 16 | Body of Lies | $8,000 | -1% | 17 | -1 | $470 | $2,105,856 | 7 | Warner Bros. | false | false |
| 30 | 20 | Nick and Norah's Infinite Playlist | $5,411 | +193.3% | 16 | +13 | $338 | $104,849 | 6 | Sony Pictures Releasing | false | false |
| 31 | - | Death Race | $5,347 | - | 4 | - | $1,336 | $1,425,792 | 11 | Universal Pictures International (UPI) | false | false |
| 32 | - | Rogue | $5,244 | - | 8 | - | $655 | $336,965 | 17 | Gussi Films | false | false |
| 33 | - | Blonde and Blonder | $5,100 | - | 12 | - | $425 | $76,807 | 15 | Quality Films | false | false |
| 34 | 23 | Lakeview Terrace | $4,320 | +424.3% | 7 | +4 | $617 | $125,212 | 8 | Sony Pictures Releasing | false | false |
| 35 | 17 | Frozen River | $2,832 | -52.4% | 7 | +4 | $404 | $56,128 | 10 | Sony Pictures Releasing | false | false |
| 36 | - | Satanás | $2,465 | - | 7 | - | $352 | $122,360 | 11 | Gussi Films | false | false |
| 37 | 13 | Free Style | $2,167 | -92.8% | 11 | -169 | $197 | $215,481 | 3 | 20th Century Fox International | false | false |
| 38 | - | An American Crime | $1,236 | - | 3 | - | $412 | $586,883 | 23 | Quality Films | false | false |
| 39 | - | Outlaw | $1,103 | - | 2 | - | $551 | $9,188 | 5 | Quality Films | false | false |
| 40 | - | Acne | $1,094 | - | 3 | - | $364 | $21,542 | 5 | David Distribucion | false | false |
| 41 | - | Pride and Glory | $1,038 | - | 5 | - | $207 | $1,273,520 | 10 | Gussi Films | false | false |
| 42 | - | Dinosaurs: Giants of Patagonia | $1,003 | - | 1 | - | $1,003 | $60,099 | 1 | Distribution Company | true | false |
| 43 | - | Lights in the Dusk | $903 | - | 1 | - | $903 | $4,418 | 2 | N/A | false | false |
| 44 | - | The Last Mistress | $860 | - | 2 | - | $430 | $20,103 | 7 | Cinemas Nueva Era | false | false |
| 45 | - | Balls of Fury | $706 | - | 1 | - | $706 | $79,866 | 10 | Gussi Films | false | false |
| 46 | - | Lake Tahoe | $656 | - | 1 | - | $656 | $34,504 | 7 | N/A | false | false |
| 47 | - | Molière | $609 | - | 3 | - | $203 | $141,745 | 19 | Universal Pictures International (UPI) | false | false |
| 48 | - | Promised Land | $579 | - | 1 | - | $579 | $25,280 | 44 | Alphaville | false | false |
| 49 | - | Espérame en otro mundo | $525 | - | 1 | - | $525 | $42,791 | 12 | Videocine | false | false |
| 50 | - | Grill Point 2008 Re-release | $483 | - | 2 | - | $241 | $1,774 | 10 | MAC Releasing | false | false |
| 51 | - | The Island 2008 Re-release | $475 | - | 1 | - | $475 | $13,120 | 5 | Zima Entertainment | false | false |
| 52 | - | Tideland | $454 | - | 2 | - | $227 | $17,754 | 14 | N/A | false | false |
| 53 | 21 | Quantum of Solace | $445 | -51.7% | 3 | -5 | $148 | $5,981,101 | 9 | Sony Pictures Releasing | false | false |
| 54 | - | Sleuth | $443 | - | 1 | - | $443 | $201,440 | 51 | Sony Pictures Releasing | false | false |
| 55 | - | The Bank Job | $425 | - | 1 | - | $425 | $1,806,999 | 20 | Gussi Films | false | false |
| 56 | - | Honeydripper | $424 | - | 1 | - | $424 | $12,175 | 14 | David Distribucion | false | false |
| 57 | - | The Unknown Woman | $408 | - | 1 | - | $408 | $83,452 | 10 | Quality Films | false | false |
| 58 | - | Hunting and Gathering | $373 | - | 1 | - | $373 | $59,796 | 11 | Cinemas Nueva Era | false | false |
| 59 | - | Anna M. | $361 | - | 2 | - | $180 | $49,802 | 18 | Alphaville | false | false |
| 60 | - | The Wedding Weekend | $317 | - | 1 | - | $317 | $5,373 | 38 | Zima Entertainment | false | false |
| 61 | - | You, the Living | $260 | - | 1 | - | $260 | $12,619 | 16 | MAC Releasing | false | false |
| 62 | - | Nights in Rodanthe | $232 | - | 1 | - | $232 | $1,804,178 | 15 | Warner Bros. | false | false |
| 63 | - | WALL·E | $213 | - | 1 | - | $213 | $17,678,004 | 28 | Walt Disney Pictures | false | false |
| 64 | - | The Air I Breathe | $213 | - | 1 | - | $213 | $755,306 | 13 | Videocine | false | false |
| 65 | - | Belle toujours 2008 Re-release | $192 | - | 1 | - | $192 | $8,275 | 15 | Cinemas Nueva Era | false | false |
| 66 | - | The Strangers | $179 | - | 1 | - | $179 | $2,381,566 | 17 | Videocine | false | false |
| 67 | - | Apartment 1303 | $170 | - | 1 | - | $170 | $158,080 | 13 | Alphaville | false | false |
| 68 | - | Funny Games | $167 | - | 1 | - | $167 | $221,139 | 16 | Universal Pictures International (UPI) | false | false |
| 69 | - | Sea Monsters: A Prehistoric Adventure | $161 | - | 1 | - | $161 | $28,823 | 16 | - | false | false |
| 70 | - | Teo's Journey | $156 | - | 2 | - | $78 | $158,274 | 14 | Videocine | false | false |
| 71 | - | College Road Trip | $145 | - | 2 | - | $72 | $2,862,598 | 23 | Walt Disney Pictures | false | false |
| 72 | - | Runaways | $131 | - | 1 | - | $131 | $1,863 | 6 | N/A | false | false |
| 73 | - | The Killing Gene | $131 | - | 1 | - | $131 | $139,566 | 11 | Quality Films | false | false |
| 74 | - | Beverly Hills Chihuahua | $129 | - | 1 | - | $129 | $7,660,801 | 15 | Walt Disney Pictures | false | false |
| 75 | - | Donkey Xote | $126 | - | 1 | - | $126 | $2,540,000 | 18 | Videocine | false | false |
| 76 | - | Joy Division | $109 | - | 1 | - | $109 | $4,538 | 13 | Canana Films | false | false |
| 77 | - | Swing Vote | $99 | - | 1 | - | $99 | $280,804 | 10 | Quality Films | false | false |
| 78 | 22 | X-mas, Inc. | $84 | -90.4% | 1 | -7 | $84 | $3,567,935 | 9 | Warner Bros. | false | false |
| 79 | - | The Host | $84 | - | 1 | - | $84 | $157,448 | 19 | Gussi Films | false | false |
| 80 | - | Cocalero 2008 Re-release | $80 | - | 1 | - | $80 | $15,846 | 19 | N/A | false | false |
| 81 | - | The Big Sellout | $60 | - | 1 | - | $60 | $20,331 | 31 | Canana Films | false | false |
| 82 | - | U2 3D | $33 | - | 1 | - | $33 | $450,557 | 20 | - | false | false |
| 83 | - | High School Musical 3: Senior Year | $30 | - | 1 | - | $30 | $4,396,880 | 11 | Walt Disney Pictures | false | false |
