| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Bride Wars | $2,122,709 | - | 286 | - | $7,422 | $2,162,859 | 1 | 20th Century Fox International | true | false |
| 2 | - | Role Models | $1,216,888 | - | 178 | - | $6,836 | $1,245,850 | 1 | Universal Pictures International (UPI) | true | false |
| 3 | 1 | Yes Man | $855,538 | -49.3% | 245 | -10 | $3,491 | $7,470,039 | 3 | Roadshow Films | false | false |
| 4 | 3 | Bolt | $797,838 | -39.8% | 285 | -12 | $2,799 | $5,818,999 | 3 | Walt Disney Pictures | false | false |
| 5 | 10 | Slumdog Millionaire | $795,772 | +77.9% | 64 | +29 | $12,433 | $3,148,496 | 5 | Icon Film Distribution | false | false |
| 6 | 2 | Seven Pounds | $742,082 | -48% | 260 | -1 | $2,854 | $2,728,358 | 2 | Sony Pictures Releasing | false | false |
| 7 | 5 | Bedtime Stories | $724,816 | -40% | 274 | -9 | $2,645 | $9,044,954 | 4 | Walt Disney Pictures | false | false |
| 8 | - | Hotel for Dogs | $715,801 | - | 176 | - | $4,067 | $736,340 | 1 | Paramount Pictures International | true | false |
| 9 | 6 | The Curious Case of Benjamin Button | $697,451 | -41.2% | 240 | -8 | $2,906 | $8,968,503 | 4 | Warner Bros. | false | false |
| 10 | 4 | Marley & Me | $640,756 | -48.1% | 220 | -2 | $2,912 | $4,926,076 | 3 | 20th Century Fox International | false | false |
| 11 | 7 | Australia | $599,851 | -33.9% | 270 | -11 | $2,221 | $22,216,287 | 8 | 20th Century Fox International | false | false |
| 12 | 8 | Madagascar: Escape 2 Africa | $435,713 | -50.9% | 238 | -46 | $1,830 | $13,864,887 | 6 | Paramount Pictures International | false | false |
| 13 | 9 | Twilight | $410,565 | -38% | 180 | -10 | $2,280 | $12,389,227 | 7 | Hoyts Distribution | false | false |
| 14 | - | Doubt | $320,557 | - | 66 | - | $4,856 | $414,673 | 1 | Walt Disney Pictures | true | false |
| 15 | 12 | The Tale of Despereaux | $254,840 | -37.4% | 193 | - | $1,320 | $992,598 | 2 | Universal Pictures International (UPI) | false | false |
| 16 | - | The Wrestler | $251,521 | - | 50 | - | $5,030 | $305,950 | 1 | Hopscotch Films | true | false |
| 17 | - | Gran Torino | $172,285 | - | 108 | - | $1,595 | $173,188 | - | Roadshow Films | - | false |
| 18 | 13 | Vicky Cristina Barcelona | $125,773 | -36.5% | 63 | - | $1,996 | $1,542,686 | 4 | Hopscotch Films | false | false |
| 19 | - | CC2C | $117,339 | - | 20 | - | $5,866 | $117,339 | 1 | Warner Bros. | true | false |
| 20 | 11 | The Day the Earth Stood Still | $111,526 | -73.2% | 125 | -114 | $892 | $5,478,905 | 4 | 20th Century Fox International | false | false |
| 21 | 16 | I've Loved You So Long | $93,456 | -25.1% | 25 | +3 | $3,738 | $872,095 | 4 | Palace Films | false | false |
| 22 | 14 | Quantum of Solace | $88,100 | -54.7% | 75 | -49 | $1,174 | $19,878,068 | 9 | Sony Pictures Releasing | false | false |
| 23 | 15 | Frost/Nixon | $75,128 | -50.4% | 57 | -2 | $1,318 | $1,091,187 | 4 | Universal Pictures International (UPI) | false | false |
| 24 | 19 | Igor | $33,758 | -56.3% | 105 | -17 | $321 | $185,788 | 2 | Roadshow Films | false | false |
| 25 | 38 | Man on Wire | $29,527 | +4,307% | 5 | +4 | $5,905 | $302,058 | 14 | Madman Entertainment | false | false |
| 26 | 21 | Wild Ocean | $29,417 | -35% | 2 | - | $14,708 | $917,874 | 31 | IMAX | false | false |
| 27 | - | Bustin' Down the Door | $21,257 | - | 5 | - | $4,251 | $21,257 | 1 | Madman Entertainment | true | false |
| 28 | 23 | Grand Canyon Adventure: River at Risk | $16,598 | -4.3% | 1 | - | $16,598 | $305,582 | 31 | IMAX | false | false |
| 29 | - | The Class | $9,486 | - | 11 | - | $862 | $9,486 | - | Sony Pictures Releasing | - | false |
| 30 | 26 | Fly Me to the Moon 3D | $9,423 | -36% | 2 | - | $4,711 | $418,228 | 18 | IMAX | false | false |
| 31 | 22 | Four Christmases | $9,409 | -59.7% | 24 | -13 | $392 | $4,899,002 | 7 | Roadshow Films | false | false |
| 32 | 27 | Santa vs. the Snowman 3D | $9,375 | -33.9% | 1 | - | $9,375 | $1,554,106 | 322 | IMAX | false | false |
| 33 | 24 | Burn After Reading | $8,876 | -48.6% | 19 | +4 | $467 | $6,484,648 | 14 | Universal Pictures International (UPI) | false | false |
| 34 | 29 | Before the Rains | $7,820 | -20.2% | 3 | - | $2,606 | $21,940 | 2 | Rialto Distribution | false | false |
| 35 | 31 | The Dark Knight | $4,704 | -8.6% | 2 | +1 | $2,352 | $39,816,780 | 27 | Warner Bros. | false | false |
| 36 | 32 | Haunted Castle | $2,764 | -15.6% | 1 | - | $2,764 | $3,534,842 | 383 | IMAX | false | false |
| 37 | 33 | African Adventure: Safari in the Okavango | $2,014 | -4.3% | 1 | - | $2,014 | $738,515 | 96 | IMAX | false | false |
| 38 | 25 | Ghajini | $1,340 | -92% | 4 | -10 | $335 | $338,434 | 4 | - | false | false |
| 39 | 34 | In Bruges | $1,070 | -26% | 4 | +1 | $267 | $2,373,004 | 21 | Icon Film Distribution | false | false |
| 40 | 35 | City of Ember | $272 | -80.9% | 3 | -2 | $90 | $299,966 | 6 | Icon Film Distribution | false | false |
| 41 | - | Black Ice 2008 Re-release | $190 | - | 1 | - | $190 | $190 | 1 | Potential Films | true | false |
