| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Bolt | $424,881 | -33% | 93 | +1 | $4,568 | $1,002,407 | 2 | Walt Disney Pictures | false | false |
| 2 | - | Changeling | $205,807 | - | 44 | - | $4,677 | $205,807 | 1 | Universal Pictures International (UPI) | true | false |
| 3 | - | Marley & Me | $184,731 | - | 56 | - | $3,298 | $184,731 | 1 | 20th Century Fox International | true | false |
| 4 | 2 | Yes Man | $180,015 | -31.1% | 50 | - | $3,600 | $552,507 | 2 | Warner Bros. | false | false |
| 5 | 4 | Twilight | $125,632 | -36.6% | 88 | +1 | $1,427 | $1,589,259 | 4 | Alfa Films | false | false |
| 6 | 3 | The Day the Earth Stood Still | $108,914 | -48.1% | 89 | -33 | $1,223 | $1,892,712 | 4 | 20th Century Fox International | false | false |
| 7 | 5 | Australia | $87,889 | -36.9% | 61 | +1 | $1,440 | $610,578 | 3 | 20th Century Fox International | false | false |
| 8 | 6 | Doubt | $82,952 | -35.6% | 26 | - | $3,190 | $261,907 | 2 | Walt Disney Pictures | false | false |
| 9 | 7 | Madagascar: Escape 2 Africa | $66,875 | -42.6% | 81 | -25 | $825 | $5,449,069 | 8 | Paramount Pictures International | false | false |
| 10 | - | The Spirit | $42,897 | - | 26 | - | $1,649 | $43,774 | 1 | Sony Pictures Releasing | true | false |
| 11 | 8 | Rudo y Cursi | $20,773 | -66.2% | 36 | -9 | $577 | $282,641 | 3 | United International Pictures | false | false |
| 12 | 10 | El ratón Pérez 2 | $20,328 | -58% | 64 | -34 | $317 | $672,008 | 4 | Walt Disney Pictures | false | false |
| 13 | 9 | Bangkok Dangerous | $15,433 | -69.2% | 30 | -1 | $514 | $83,937 | 2 | Distribution Company | false | false |
| 14 | - | Blame it on Fidel | $9,433 | - | 7 | - | $1,347 | $9,433 | 1 | Zeta Films | true | false |
| 15 | 11 | W. | $9,089 | -72.2% | 13 | - | $699 | $51,607 | 2 | Impacto Cine | false | false |
| 16 | 12 | Four Christmases | $5,674 | -61.2% | 17 | -7 | $333 | $412,659 | 6 | Distribution Company | false | false |
| 17 | 14 | The Duchess | $5,324 | -41.5% | 9 | -1 | $591 | $241,184 | 7 | United International Pictures | false | false |
| 18 | 22 | Righteous Kill | $5,296 | +96.4% | 12 | +5 | $441 | $572,880 | 10 | CDI Films | false | false |
| 19 | 23 | RocknRolla | $4,691 | +90.7% | 8 | +5 | $586 | $84,368 | 7 | Warner Bros. | false | false |
| 20 | 13 | Body of Lies | $4,209 | -67.4% | 16 | -16 | $263 | $921,223 | 9 | Warner Bros. | false | false |
| 21 | 19 | High School Musical 3: Senior Year | $3,499 | -5.3% | 10 | +2 | $349 | $1,207,606 | 9 | Walt Disney Pictures | false | false |
| 22 | - | Deception | $2,526 | - | 3 | - | $842 | $64,049 | 7 | Alfa Films | false | false |
| 23 | 18 | Late Bloomers | $2,257 | -39.1% | 4 | - | $564 | $72,612 | 9 | Primer Plano Film Group | false | false |
| 24 | 15 | Planet Terror | $2,173 | -50.9% | 4 | -7 | $543 | $92,351 | 7 | Pachamama Cine | false | false |
| 25 | 20 | Quarantine | $1,361 | -61.4% | 4 | -4 | $340 | $333,721 | 8 | Sony Pictures Releasing | false | false |
| 26 | 16 | Che: Part One | $1,280 | -68.8% | 2 | -4 | $640 | $669,405 | 11 | Alfa Films | false | false |
| 27 | 33 | Aniceto | $1,002 | +50.9% | 3 | +1 | $334 | $135,631 | 33 | Primer Plano Film Group | false | false |
| 28 | 32 | Flawless | $868 | +28.8% | 2 | - | $434 | $256,910 | 12 | Distribution Company | false | false |
| 29 | 25 | The Tracker 2008 Re-release | $779 | -49.6% | 2 | -1 | $389 | $47,374 | 5 | IFA | false | false |
| 30 | 24 | Asterix at the Olympic Games | $750 | -65.4% | 11 | - | $68 | $47,348 | 3 | Distribution Company | false | false |
| 31 | 17 | Bug | $750 | -81.2% | 2 | -1 | $375 | $6,194 | 2 | Alfa Films | false | false |
| 32 | 21 | The Pope's Toilet | $647 | -80.3% | 2 | -2 | $323 | $26,731 | 4 | Primer Plano Film Group | false | false |
| 33 | 34 | The Boy in the Striped Pajamas | $498 | -6.6% | 3 | +1 | $166 | $78,452 | 8 | Walt Disney Pictures | false | false |
| 34 | 27 | Death Sentence | $481 | -62.2% | 3 | - | $160 | $188,391 | 8 | Distribution Company | false | false |
| 35 | 31 | Elegy | $409 | -45.7% | 1 | - | $409 | $175,275 | 10 | Distribution Company | false | false |
| 36 | 37 | Manual of Love 2008 Re-release | $340 | -23.1% | 2 | - | $170 | $136,342 | 18 | Notro Films | false | false |
| 37 | 26 | Quantum of Solace | $333 | -75% | 1 | -1 | $333 | $1,280,370 | 12 | Sony Pictures Releasing | false | false |
| 38 | 28 | Saw V | $283 | -70.8% | 2 | - | $141 | $1,035,187 | 13 | Walt Disney Pictures | false | false |
| 39 | 36 | Fados | $253 | -46.4% | 1 | - | $253 | $35,175 | 9 | Distribution Company | false | false |
| 40 | 30 | Beverly Hills Chihuahua | $244 | -74.5% | 2 | -1 | $122 | $1,532,522 | 16 | Walt Disney Pictures | false | false |
| 41 | 52 | Fly Me to the Moon 3D | $226 | +479.5% | 2 | +1 | $113 | $131,259 | 6 | Distribution Company | false | false |
| 42 | - | La próxima estación | $223 | - | 1 | - | $223 | $123,121 | 21 | Primer Plano Film Group | false | false |
| 43 | 48 | Café de los maestros | $186 | +70.6% | 1 | - | $186 | $97,093 | 31 | Alfa Films | false | false |
| 44 | 39 | Burn After Reading | $174 | -35.8% | 1 | - | $174 | $856,397 | 14 | United International Pictures | false | false |
| 45 | 50 | Max Payne | $156 | +155.7% | 1 | - | $156 | $166,837 | 10 | 20th Century Fox International | false | false |
| 46 | - | Death Defying Acts | $154 | - | 1 | - | $154 | $120,629 | 9 | Alfa Films | false | false |
| 47 | 38 | Four Minutes | $139 | -50.9% | 1 | - | $139 | $159,960 | 22 | Alfa Films | false | false |
| 48 | 51 | Two Friends and a Burglar | $131 | +125.9% | 1 | - | $131 | $9,799 | 9 | Primer Plano Film Group | false | false |
| 49 | - | La leyenda | $101 | - | 1 | - | $101 | $215,711 | 10 | United International Pictures | false | false |
| 50 | 46 | Shara | $93 | -23.1% | 1 | - | $93 | $44,103 | 13 | Zeta Films | false | false |
| 51 | 43 | Bella | $87 | -46.3% | 1 | - | $87 | $31,283 | 5 | CDI Films | false | false |
| 52 | 49 | Mamma Mia! | $75 | -27.9% | 1 | - | $75 | $1,453,523 | 23 | United International Pictures | false | false |
| 53 | 44 | Days of Darkness | $46 | -68.1% | 1 | - | $46 | $15,773 | 15 | Alfa Films | false | false |
| 54 | 40 | Ben X | $41 | -84.7% | 1 | -3 | $41 | $26,687 | 4 | Distribution Company | false | false |
| 55 | 45 | My Brother is an Only Child | $35 | -73.7% | 1 | - | $35 | $222,886 | 19 | Alfa Films | false | false |
| 56 | 41 | The Magic Flute | $29 | -86.9% | 1 | -1 | $29 | $27,214 | 14 | Distribution Company | false | false |
