| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | The Curious Case of Benjamin Button | $155,549 | - | 30 | - | $5,184 | $155,549 | 1 | Warner Bros. | true | false |
| 2 | 1 | Yes Man | $119,409 | -28.9% | 40 | - | $2,985 | $381,732 | 2 | Warner Bros. | false | false |
| 3 | 2 | Bolt | $97,555 | -14.1% | 46 | +8 | $2,120 | $1,245,716 | 5 | Walt Disney Pictures | false | false |
| 4 | 3 | Twilight | $71,992 | -33.8% | 37 | -2 | $1,945 | $943,671 | 4 | Bazuca Films | false | false |
| 5 | 4 | Beverly Hills Chihuahua | $64,504 | -26.4% | 38 | +3 | $1,697 | $378,092 | 3 | Walt Disney Pictures | false | false |
| 6 | - | Hotel for Dogs | $46,531 | - | 22 | - | $2,115 | $46,531 | 1 | United International Pictures | true | false |
| 7 | 7 | The Boy in the Striped Pajamas | $35,371 | -6.3% | 11 | +3 | $3,215 | $98,297 | 2 | Walt Disney Pictures | false | false |
| 8 | 5 | Marley & Me | $32,446 | -47.1% | 27 | -1 | $1,201 | $128,063 | 2 | 20th Century Fox International | false | false |
| 9 | 6 | Australia | $31,013 | -49.1% | 30 | -9 | $1,033 | $266,811 | 3 | 20th Century Fox International | false | false |
| 10 | - | The Strangers | $26,592 | - | 13 | - | $2,045 | $26,592 | 1 | Bazuca Films | true | false |
| 11 | 8 | Madagascar: Escape 2 Africa | $12,296 | -55.5% | 18 | +11 | $683 | $1,781,554 | 8 | United International Pictures | false | false |
| 12 | 9 | Burn After Reading | $11,851 | -47.9% | 4 | -11 | $2,962 | $112,011 | 3 | United International Pictures | false | false |
| 13 | - | The Spirit | $10,554 | - | 10 | - | $1,055 | $10,554 | 1 | Sony Pictures Releasing | true | false |
| 14 | - | W. | $9,148 | - | 4 | - | $2,287 | $9,148 | 1 | Impacto Cine | true | false |
| 15 | 11 | In Bruges | $7,222 | -58% | 6 | -3 | $1,203 | $31,912 | 2 | Bazuca Films | false | false |
| 16 | 10 | The Day the Earth Stood Still | $6,703 | -63% | 10 | -8 | $670 | $1,060,433 | 7 | 20th Century Fox International | false | false |
| 17 | 12 | El Regalo | $2,003 | -50.9% | 1 | -1 | $2,003 | $717,237 | 17 | - | false | false |
| 18 | 15 | Body of Lies | $1,417 | +36.5% | 2 | - | $708 | $231,101 | 10 | Warner Bros. | false | false |
| 19 | 16 | Four Christmases | $291 | -58.1% | 1 | - | $291 | $92,061 | 6 | Warner Bros. | false | false |
