| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Valkyrie | $906,977 | - | 96 | - | $9,447 | $906,977 | 1 | Warner Bros. | true | false |
| 2 | 1 | Yes Man | $482,329 | -31.2% | 87 | -1 | $5,544 | $2,320,103 | 3 | Warner Bros. | false | false |
| 3 | 2 | Winter in Wartime | $275,678 | -36.3% | 100 | - | $2,756 | $6,756,452 | 9 | Benelux Film Distributors | false | false |
| 4 | 3 | Australia | $271,449 | -29.1% | 100 | -4 | $2,714 | $3,448,072 | 6 | Warner Bros. | false | false |
| 5 | - | Revolutionary Road | $189,218 | - | 44 | - | $4,300 | $189,821 | 1 | Universal Pictures International (UPI) | true | false |
| 6 | 4 | Seven Pounds | $156,218 | -42% | 41 | - | $3,810 | $490,431 | 2 | Sony Pictures Releasing | false | false |
| 7 | 5 | Madagascar: Escape 2 Africa | $147,756 | -28.8% | 123 | -10 | $1,201 | $7,816,171 | 10 | Universal Pictures International (UPI) | false | false |
| 8 | 6 | The Silent Army | $116,696 | -34.4% | 84 | -5 | $1,389 | $2,589,068 | 7 | Independent Films | false | false |
| 9 | - | Zack and Miri Make a Porno | $96,228 | - | 55 | - | $1,749 | $124,066 | 1 | Benelux Film Distributors | true | false |
| 10 | 7 | High School Musical 3: Senior Year | $78,700 | -27.9% | 101 | -6 | $779 | $2,594,237 | 7 | Walt Disney Pictures | false | false |
| 11 | 8 | Righteous Kill | $64,975 | -33% | 23 | -7 | $2,825 | $371,053 | 3 | Moonlight Films | false | false |
| 12 | - | Milk | $63,807 | - | 21 | - | $3,038 | $72,666 | 1 | A-Film Distribution | true | false |
| 13 | 10 | Vicky Cristina Barcelona | $60,497 | -28% | 20 | -1 | $3,024 | $921,217 | 7 | Cinéart | false | false |
| 14 | 9 | Bedtime Stories | $54,159 | -40.9% | 60 | - | $902 | $1,284,996 | 5 | Walt Disney Pictures | false | false |
| 15 | 13 | The Boy in the Striped Pajamas | $33,773 | -41.1% | 28 | - | $1,206 | $193,707 | 3 | Walt Disney Pictures | false | false |
| 16 | 11 | Saw V | $24,626 | -69.4% | 33 | -25 | $746 | $458,431 | 3 | Benelux Film Distributors | false | false |
| 17 | 12 | Frost/Nixon | $23,530 | -63.7% | 29 | - | $811 | $108,142 | 2 | Universal Pictures International (UPI) | false | false |
| 18 | 18 | The Class | $23,372 | -26.4% | 19 | - | $1,230 | $591,211 | 9 | Cinéart | false | false |
| 19 | 19 | Piet Piraat en het zwaard van Zilvertand | $22,520 | -25.7% | 70 | -4 | $321 | $456,999 | 6 | Independent Films | false | false |
| 20 | - | Bride Flight | $21,701 | - | 30 | - | $723 | $3,319,801 | 15 | A-Film Distribution | false | false |
| 21 | 14 | CC2C | $21,500 | -52.9% | 5 | -1 | $4,300 | $70,768 | 2 | Warner Bros. | false | false |
| 22 | 15 | Quantum of Solace | $12,321 | -72.4% | 19 | -26 | $648 | $8,869,860 | 12 | Sony Pictures Releasing | false | false |
| 23 | 22 | Changeling | $7,335 | -67% | 22 | - | $333 | $692,272 | 8 | Universal Pictures International (UPI) | false | false |
| 24 | - | Links | $1,588 | - | 4 | - | $397 | $1,588 | 1 | N/A | true | false |
| 25 | - | God's Offices | $1,166 | - | 3 | - | $388 | $1,166 | 1 | Cinéart | true | false |
| 26 | - | Pride and Glory | $271 | - | 2 | - | $135 | $242,024 | 8 | RCV Film Distribution | false | false |
