| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | The Curious Case of Benjamin Button | $136,475 | -12.3% | 36 | +6 | $3,790 | $555,351 | 2 | Warner Bros. | false | false |
| 2 | 2 | Yes Man | $107,500 | -10% | 43 | +3 | $2,500 | $560,173 | 3 | Warner Bros. | false | false |
| 3 | 3 | Bolt | $81,456 | -16.5% | 36 | -10 | $2,262 | $1,404,543 | 6 | Walt Disney Pictures | false | false |
| 4 | - | Quarantine | $55,348 | - | 28 | - | $1,976 | $55,348 | 1 | Sony Pictures Releasing | true | false |
| 5 | - | The Tale of Despereaux | $51,452 | - | 33 | - | $1,559 | $51,452 | 1 | United International Pictures | true | false |
| 6 | - | Bride Wars | $47,147 | - | 28 | - | $1,683 | $47,147 | 1 | 20th Century Fox International | true | false |
| 7 | 4 | Twilight | $44,494 | -38.2% | 28 | -9 | $1,589 | $1,092,437 | 5 | Bazuca Films | false | false |
| 8 | - | Revolutionary Road | $40,992 | - | 22 | - | $1,863 | $40,992 | 1 | United International Pictures | true | false |
| 9 | 5 | Beverly Hills Chihuahua | $37,464 | -41.9% | 29 | -9 | $1,291 | $458,842 | 4 | Walt Disney Pictures | false | false |
| 10 | - | Che: Part One | $35,804 | - | 17 | - | $2,106 | $35,804 | 1 | Bazuca Films | true | false |
| 11 | 6 | Hotel for Dogs | $30,588 | -34.3% | 23 | +1 | $1,329 | $107,874 | 2 | United International Pictures | false | false |
| 12 | 7 | The Boy in the Striped Pajamas | $25,685 | -27.4% | 11 | - | $2,335 | $146,783 | 3 | Walt Disney Pictures | false | false |
| 13 | 10 | The Strangers | $12,591 | -52.7% | 12 | -1 | $1,049 | $58,697 | 2 | Bazuca Films | false | false |
| 14 | 9 | Australia | $12,296 | -60.4% | 7 | -23 | $1,756 | $299,911 | 4 | 20th Century Fox International | false | false |
| 15 | 12 | Burn After Reading | $7,440 | -37.2% | 3 | -1 | $2,480 | $127,840 | 4 | United International Pictures | false | false |
| 16 | 8 | Marley & Me | $6,567 | -79.8% | 8 | -19 | $820 | $154,131 | 3 | 20th Century Fox International | false | false |
| 17 | 11 | Madagascar: Escape 2 Africa | $3,415 | -72.2% | 3 | -15 | $1,138 | $1,840,229 | 9 | United International Pictures | false | false |
| 18 | 13 | The Spirit | $2,340 | -77.8% | 5 | -5 | $468 | $18,706 | 2 | Sony Pictures Releasing | false | false |
| 19 | 17 | El Regalo | $1,865 | -6.9% | 1 | - | $1,865 | $734,849 | 18 | - | false | false |
| 20 | 14 | W. | $1,851 | -79.8% | 2 | -2 | $925 | $8,808 | 2 | Impacto Cine | false | false |
| 21 | 15 | In Bruges | $1,661 | -77% | 1 | -5 | $1,661 | $36,990 | 3 | Bazuca Films | false | false |
| 22 | 16 | The Day the Earth Stood Still | $400 | -94% | 1 | -9 | $400 | $1,099,037 | 8 | 20th Century Fox International | false | false |
| 23 | 18 | Body of Lies | $280 | -80.2% | 1 | -1 | $280 | $234,585 | 11 | Warner Bros. | false | false |
