| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | The Curious Case of Benjamin Button | $467,774 | -28% | 78 | +3 | $5,997 | $1,846,233 | 3 | Warner Bros. | false | false |
| 2 | 2 | Twilight | $359,984 | -40.3% | 82 | +2 | $4,390 | $2,133,498 | 13 | Ascot Elite Entertainment Group | false | false |
| 3 | 4 | Slumdog Millionaire | $254,089 | -9.6% | 31 | +2 | $8,196 | $1,633,413 | 6 | Pathé | false | false |
| 4 | - | The International | $213,850 | - | 36 | - | $5,940 | $213,850 | 1 | Walt Disney Pictures | true | false |
| 5 | 3 | Bolt | $191,066 | -40.8% | 73 | -1 | $2,617 | $1,266,802 | 12 | Walt Disney Pictures | false | false |
| 6 | - | He's Just Not That Into You | $190,464 | - | 33 | - | $5,771 | $190,464 | 1 | Warner Bros. | true | false |
| 7 | - | Friday the 13th | $165,521 | - | 25 | - | $6,620 | $165,521 | 1 | Universal Pictures International (UPI) | true | false |
| 8 | 5 | Revolutionary Road | $163,458 | -36.2% | 40 | -5 | $4,086 | $1,860,381 | 5 | Universal Pictures International (UPI) | false | false |
| 9 | 7 | Hotel for Dogs | $156,956 | -13.2% | 45 | +1 | $3,487 | $372,144 | 2 | Universal Pictures International (UPI) | false | false |
| 10 | 8 | Bride Wars | $123,643 | -31% | 38 | +6 | $3,253 | $355,502 | 2 | 20th Century Fox International | false | false |
| 11 | 6 | Valkyrie | $97,685 | -52.9% | 45 | -16 | $2,170 | $1,105,134 | 4 | 20th Century Fox International | false | false |
| 12 | 9 | Australia | $93,572 | -43.6% | 33 | -17 | $2,835 | $5,088,627 | 8 | 20th Century Fox International | false | false |
| 13 | 10 | Transporter 3 | $79,152 | -38.1% | 12 | - | $6,596 | $539,593 | 7 | JMH Distribution | false | false |
| 14 | 13 | Doubt | $75,744 | +13.7% | 16 | +7 | $4,734 | $168,079 | 3 | Walt Disney Pictures | false | false |
| 15 | 11 | Changeling | $53,658 | -45% | 24 | -10 | $2,235 | $1,372,186 | 14 | Universal Pictures International (UPI) | false | false |
| 16 | - | Frost/Nixon | $50,790 | - | 19 | - | $2,673 | $50,790 | 1 | Universal Pictures International (UPI) | true | false |
| 17 | 12 | Madagascar: Escape 2 Africa | $43,913 | -54% | 44 | -17 | $998 | $10,944,037 | 11 | Universal Pictures International (UPI) | false | false |
| 18 | 15 | The Class | $42,873 | -33.3% | 10 | +1 | $4,287 | $732,361 | 21 | Filmcoopi | false | false |
| 19 | 19 | LOL (Laughing Out Loud) | $35,010 | -10.7% | 3 | - | $11,670 | $89,316 | 2 | Pathé | false | false |
| 20 | 17 | Yes Man | $33,624 | -29% | 12 | -1 | $2,802 | $374,452 | 6 | Warner Bros. | false | false |
| 21 | - | The Tale of Despereaux | $26,511 | - | 14 | - | $1,893 | $26,511 | 1 | Universal Pictures International (UPI) | true | false |
| 22 | 14 | Seven Pounds | $20,879 | -67.7% | 13 | -20 | $1,606 | $1,621,585 | 6 | Sony Pictures Releasing | false | false |
| 23 | 16 | The Spirit | $15,704 | -70.5% | 15 | -1 | $1,046 | $168,719 | 8 | Walt Disney Pictures | false | false |
| 24 | 23 | Burn After Reading | $4,998 | -60.2% | 4 | -5 | $1,249 | $3,012,363 | 22 | Ascot Elite Entertainment Group | false | false |
| 25 | 24 | Fly Me to the Moon 3D | $2,714 | -26% | 1 | - | $2,714 | $94,808 | 16 | N/A | false | false |
| 26 | 25 | Milk | $1,515 | -55.7% | 1 | - | $1,515 | $16,486 | 4 | Ascot Elite Entertainment Group | false | false |
