| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | The Curious Case of Benjamin Button | $105,565 | -22.6% | 35 | -1 | $3,016 | $577,242 | 3 | Warner Bros. | false | false |
| 2 | - | Inkheart | $103,187 | - | 45 | - | $2,293 | $103,187 | 1 | Warner Bros. | true | false |
| 3 | 2 | Yes Man | $65,300 | -39.3% | 36 | -7 | $1,813 | $686,059 | 4 | Warner Bros. | false | false |
| 4 | 3 | Bolt | $48,421 | -40.6% | 30 | -6 | $1,614 | $1,501,388 | 7 | Walt Disney Pictures | false | false |
| 5 | 4 | Quarantine | $31,038 | -43.9% | 25 | -3 | $1,241 | $120,894 | 2 | Sony Pictures Releasing | false | false |
| 6 | - | The Pink Panther 2 | $30,740 | - | 28 | - | $1,097 | $30,740 | 1 | Sony Pictures Releasing | true | false |
| 7 | 7 | Twilight | $27,845 | -37.4% | 29 | +1 | $960 | $1,154,522 | 6 | Bazuca Films | false | false |
| 8 | - | The Forbidden Kingdom | $23,038 | - | 29 | - | $794 | $23,038 | 1 | Andes Films | true | false |
| 9 | 6 | Bride Wars | $22,538 | -52.2% | 24 | -4 | $939 | $99,688 | 2 | 20th Century Fox International | false | false |
| 10 | 5 | The Tale of Despereaux | $21,983 | -57.3% | 32 | -1 | $686 | $111,421 | 2 | United International Pictures | false | false |
| 11 | 11 | Hotel for Dogs | $21,386 | -30.1% | 14 | -9 | $1,527 | $155,588 | 3 | United International Pictures | false | false |
| 12 | - | Coraline | $20,690 | - | 7 | - | $2,955 | $20,690 | 1 | United International Pictures | true | false |
| 13 | 8 | Revolutionary Road | $19,362 | -52.8% | 14 | -8 | $1,383 | $80,157 | 2 | United International Pictures | false | false |
| 14 | - | Elegy | $18,191 | - | 10 | - | $1,819 | $18,191 | 1 | Bazuca Films | true | false |
| 15 | 10 | Che: Part One | $18,047 | -49.6% | 12 | -5 | $1,503 | $73,941 | 2 | Bazuca Films | false | false |
| 16 | 12 | The Boy in the Striped Pajamas | $18,023 | -29.8% | 14 | +3 | $1,287 | $180,567 | 4 | Walt Disney Pictures | false | false |
| 17 | 9 | Beverly Hills Chihuahua | $16,183 | -56.8% | 17 | -12 | $951 | $498,507 | 5 | Walt Disney Pictures | false | false |
| 18 | 14 | Australia | $7,539 | -38.7% | 2 | -5 | $3,769 | $313,203 | 5 | 20th Century Fox International | false | false |
| 19 | 13 | The Strangers | $6,599 | -47.6% | 5 | -7 | $1,319 | $72,917 | 3 | Bazuca Films | false | false |
| 20 | 15 | Burn After Reading | $4,081 | -45.1% | 3 | - | $1,360 | $133,617 | 5 | United International Pictures | false | false |
| 21 | 17 | Madagascar: Escape 2 Africa | $1,800 | -47.3% | 5 | +2 | $360 | $1,843,968 | 10 | United International Pictures | false | false |
| 22 | 21 | In Bruges | $1,329 | -20% | 1 | - | $1,329 | $38,989 | 4 | Bazuca Films | false | false |
| 23 | 18 | The Spirit | $366 | -84.4% | 2 | -3 | $183 | $20,637 | 3 | Sony Pictures Releasing | false | false |
| 24 | 16 | Marley & Me | $175 | -97.3% | 2 | -6 | $87 | $158,418 | 4 | 20th Century Fox International | false | false |
