| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | The Curious Case of Benjamin Button | $308,213 | -37.6% | 52 | +1 | $5,927 | $987,813 | 2 | Warner Bros. | false | false |
| 2 | 2 | Bedtime Stories | $280,698 | -37.7% | 69 | +5 | $4,068 | $942,415 | 2 | Walt Disney Pictures | false | false |
| 3 | - | Valkyrie | $207,222 | - | 63 | - | $3,289 | $207,222 | 1 | 20th Century Fox International | true | false |
| 4 | - | Slumdog Millionaire | $120,313 | - | 41 | - | $2,934 | $120,313 | 1 | Distribution Company | true | false |
| 5 | - | Friday the 13th | $119,008 | - | 32 | - | $3,719 | $119,008 | 1 | Paramount Pictures International | true | false |
| 6 | 4 | Vicky Cristina Barcelona | $103,108 | -42.3% | 34 | +2 | $3,032 | $341,705 | 2 | Pachamama Cine | false | false |
| 7 | 5 | Yes Man | $81,186 | -33.4% | 57 | +6 | $1,424 | $1,146,650 | 5 | Warner Bros. | false | false |
| 8 | 6 | Underworld: Rise of the Lycans | $71,235 | -39.1% | 30 | - | $2,374 | $230,756 | 2 | Sony Pictures Releasing | false | false |
| 9 | 3 | Bolt | $70,705 | -66.1% | 121 | +12 | $584 | $2,108,270 | 5 | Walt Disney Pictures | false | false |
| 10 | - | Milk | $55,017 | - | 33 | - | $1,667 | $55,017 | 1 | Universal Pictures International (UPI) | true | false |
| 11 | 7 | Changeling | $53,419 | -52.7% | 47 | +3 | $1,136 | $749,665 | 4 | Universal Pictures International (UPI) | false | false |
| 12 | 9 | Marley & Me | $31,401 | -51.7% | 53 | -3 | $592 | $594,133 | 4 | 20th Century Fox International | false | false |
| 13 | 8 | The Tale of Despereaux | $26,302 | -67% | 56 | +6 | $469 | $138,981 | 2 | United International Pictures | false | false |
| 14 | 14 | Doubt | $23,709 | -8.3% | 26 | +1 | $911 | $451,550 | 5 | Walt Disney Pictures | false | false |
| 15 | 10 | Inkheart | $19,182 | -67.5% | 48 | +1 | $399 | $342,629 | 3 | Distribution Company | false | false |
| 16 | 11 | Revolutionary Road | $17,805 | -63.7% | 31 | +8 | $574 | $234,802 | 3 | Paramount Pictures International | false | false |
| 17 | 12 | Australia | $16,292 | -61.2% | 43 | -12 | $378 | $811,345 | 6 | 20th Century Fox International | false | false |
| 18 | 13 | Twilight | $14,270 | -56.7% | 35 | -6 | $407 | $1,877,115 | 7 | Alfa Films | false | false |
| 19 | 16 | The Day the Earth Stood Still | $7,725 | -59.8% | 19 | -11 | $406 | $1,949,315 | 7 | 20th Century Fox International | false | false |
| 20 | 15 | Madagascar: Escape 2 Africa | $4,461 | -82.5% | 36 | -7 | $123 | $5,384,220 | 11 | Paramount Pictures International | false | false |
| 21 | 18 | Emma's Bliss | $2,673 | -51.3% | 4 | -1 | $668 | $24,720 | 3 | Primer Plano Film Group | false | false |
| 22 | 17 | Bangkok Dangerous | $2,380 | -59.8% | 13 | -4 | $183 | $118,355 | 5 | Distribution Company | false | false |
| 23 | 21 | Blame it on Fidel | $2,281 | -32.8% | 4 | +2 | $570 | $32,718 | 4 | Zeta Films | false | false |
| 24 | 27 | The Spirit | $1,835 | +3.9% | 8 | +5 | $229 | $101,355 | 4 | Sony Pictures Releasing | false | false |
| 25 | 22 | Body of Lies | $1,526 | -46% | 7 | -1 | $218 | $924,660 | 12 | Warner Bros. | false | false |
| 26 | 19 | The Duchess | $1,480 | -65.7% | 6 | -2 | $246 | $258,941 | 10 | United International Pictures | false | false |
| 27 | - | WALL·E | $1,176 | - | 1 | - | $1,176 | $4,664,019 | 32 | Walt Disney Pictures | false | false |
| 28 | 23 | Righteous Kill | $937 | -64.9% | 2 | -3 | $468 | $577,694 | 13 | CDI Films | false | false |
| 29 | 46 | Death Sentence | $610 | +369.2% | 1 | -1 | $610 | $188,262 | 11 | Distribution Company | false | false |
| 30 | 25 | Rudo y Cursi | $593 | -72.1% | 4 | -4 | $148 | $309,040 | 6 | United International Pictures | false | false |
| 31 | 34 | Che: Part One | $587 | -24.9% | 2 | - | $293 | $666,802 | 14 | Alfa Films | false | false |
| 32 | 26 | Four Christmases | $555 | -69.1% | 2 | -3 | $277 | $419,092 | 9 | Distribution Company | false | false |
| 33 | 33 | W. | $457 | -43.6% | 5 | - | $91 | $66,406 | 5 | Impacto Cine | false | false |
| 34 | 20 | El ratón Pérez 2 | $337 | -90.5% | 6 | -11 | $56 | $721,029 | 7 | Walt Disney Pictures | false | false |
| 35 | - | U2 3D | $298 | - | 1 | - | $298 | $143,198 | 47 | IMAX | false | false |
| 36 | 32 | Fados | $258 | -70.4% | 1 | -2 | $258 | $37,153 | 12 | Distribution Company | false | false |
| 37 | 41 | La próxima estación | $250 | -24% | 2 | +1 | $125 | $122,568 | 24 | Primer Plano Film Group | false | false |
| 38 | 24 | Late Bloomers | $177 | -93% | 2 | -5 | $88 | $79,876 | 12 | Primer Plano Film Group | false | false |
| 39 | 47 | The Tracker 2008 Re-release | $174 | +38.1% | 1 | - | $174 | $47,895 | 8 | IFA | false | false |
| 40 | 38 | Manual of Love 2008 Re-release | $170 | -57.1% | 1 | - | $170 | $136,530 | 21 | Notro Films | false | false |
| 41 | 30 | Deception | $120 | -87.6% | 1 | -2 | $120 | $68,776 | 10 | Alfa Films | false | false |
| 42 | 48 | Burn After Reading | $86 | -25.2% | 1 | - | $86 | $882,934 | 17 | United International Pictures | false | false |
| 43 | 39 | The Camera Obscura 2008 Re-release | $85 | -76.5% | 1 | - | $85 | $65,026 | 18 | Distribution Company | false | false |
| 44 | 43 | The Pope's Toilet | $80 | -60.2% | 1 | - | $80 | $28,560 | 7 | Primer Plano Film Group | false | false |
| 45 | 56 | Eagle Eye | $78 | +188.9% | 1 | - | $78 | $189,322 | 21 | United International Pictures | false | false |
| 46 | 55 | Beverly Hills Chihuahua | $77 | +165.5% | 1 | - | $77 | $1,559,499 | 19 | Walt Disney Pictures | false | false |
| 47 | 28 | Fly Me to the Moon 3D | $69 | -94.9% | 1 | -3 | $69 | $79,582 | 9 | Distribution Company | false | false |
| 48 | - | My Mom's New Boyfriend | $67 | - | 1 | - | $67 | $147,898 | 14 | - | false | false |
| 49 | 44 | Café de los maestros | $43 | -74.7% | 1 | - | $43 | $96,393 | 34 | Alfa Films | false | false |
| 50 | 45 | Two Friends and a Burglar | $35 | -76.2% | 1 | - | $35 | $10,128 | 12 | Primer Plano Film Group | false | false |
| 51 | 37 | High School Musical 3: Senior Year | $18 | -96.1% | 1 | -2 | $18 | $1,313,070 | 12 | Walt Disney Pictures | false | false |
| 52 | 52 | Bella | $17 | -70.7% | 1 | - | $17 | $31,226 | 8 | CDI Films | false | false |
| 53 | 42 | Tear This Heart Out | $12 | -95.7% | 1 | -1 | $12 | $57,357 | 12 | 20th Century Fox International | false | false |
| 54 | 29 | RocknRolla | $9 | -99.1% | 2 | -5 | $4 | $91,117 | 10 | Warner Bros. | false | false |
