| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 5 | 12 | Coraline | $58,630 | +183.4% | 26 | +19 | $2,255 | $91,288 | 2 | United International Pictures | false | false |
| 11 | 11 | Hotel for Dogs | $17,503 | -18.2% | 16 | +2 | $1,093 | $178,689 | 4 | United International Pictures | false | false |
| 22 | 18 | Australia | $5,205 | -31% | 3 | +1 | $1,735 | $323,645 | 6 | 20th Century Fox International | false | false |
| 2 | 1 | The Curious Case of Benjamin Button | $89,888 | -14.9% | 35 | - | $2,568 | $726,519 | 4 | Warner Bros. | false | false |
| 24 | 23 | The Spirit | $395 | +7.9% | 2 | - | $197 | $21,635 | 4 | Sony Pictures Releasing | false | false |
| 8 | 4 | Bolt | $38,465 | -20.6% | 29 | -1 | $1,326 | $1,570,864 | 8 | Walt Disney Pictures | false | false |
| 3 | 2 | Inkheart | $76,326 | -26% | 43 | -2 | $1,775 | $237,970 | 2 | Warner Bros. | false | false |
| 12 | 6 | The Pink Panther 2 | $15,205 | -50.5% | 26 | -2 | $584 | $63,555 | 2 | Sony Pictures Releasing | false | false |
| 27 | 20 | Burn After Reading | $72 | -98.2% | 1 | -2 | $72 | $145,102 | 6 | United International Pictures | false | false |
| 23 | 19 | The Strangers | $2,343 | -64.5% | 2 | -3 | $1,171 | $79,155 | 4 | Bazuca Films | false | false |
| 20 | 14 | Elegy | $7,140 | -60.7% | 6 | -4 | $1,190 | $33,903 | 2 | Bazuca Films | false | false |
| 26 | 21 | Madagascar: Escape 2 Africa | $82 | -95.4% | 1 | -4 | $82 | $1,974,688 | 11 | United International Pictures | false | false |
| 14 | 16 | The Boy in the Striped Pajamas | $13,453 | -25.4% | 9 | -5 | $1,494 | $204,920 | 5 | Walt Disney Pictures | false | false |
| 13 | 13 | Revolutionary Road | $13,668 | -29.4% | 8 | -6 | $1,708 | $103,676 | 3 | United International Pictures | false | false |
| 10 | 5 | Quarantine | $21,508 | -30.7% | 18 | -7 | $1,194 | $162,118 | 3 | Sony Pictures Releasing | false | false |
| 7 | 3 | Yes Man | $50,759 | -22.3% | 28 | -8 | $1,812 | $784,173 | 5 | Warner Bros. | false | false |
| 17 | 17 | Beverly Hills Chihuahua | $10,267 | -36.6% | 9 | -8 | $1,140 | $519,727 | 6 | Walt Disney Pictures | false | false |
| 18 | 15 | Che: Part One | $9,502 | -47.3% | 4 | -8 | $2,375 | $93,435 | 3 | Bazuca Films | false | false |
| 16 | 10 | The Tale of Despereaux | $10,811 | -50.8% | 23 | -9 | $470 | $130,934 | 3 | United International Pictures | false | false |
| 15 | 9 | Bride Wars | $11,708 | -48.1% | 14 | -10 | $836 | $124,848 | 3 | 20th Century Fox International | false | false |
| 9 | 7 | Twilight | $22,624 | -18.8% | 17 | -12 | $1,330 | $1,202,210 | 7 | Bazuca Films | false | false |
| 21 | 8 | The Forbidden Kingdom | $6,045 | -73.8% | 17 | -12 | $355 | $41,940 | 2 | Andes Films | false | false |
| 1 | - | Valkyrie | $200,414 | - | 43 | - | $4,660 | $200,414 | 1 | 20th Century Fox International | true | false |
| 4 | - | Friday the 13th | $62,190 | - | 21 | - | $2,961 | $62,190 | 1 | United International Pictures | true | false |
| 6 | - | He's Just Not That Into You | $52,371 | - | 22 | - | $2,380 | $52,371 | 1 | Warner Bros. | true | false |
| 19 | - | Family Hero | $8,321 | - | 3 | - | $2,773 | $8,321 | 1 | Andes Films | true | false |
| 25 | - | Black Christmas | $152 | - | 1 | - | $152 | $48,664 | 9 | Bazuca Films | false | false |
