| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | The Curious Case of Benjamin Button | $724,836 | - | - | - | - | $907,443 | 1 | Warner Bros. | true | false |
| 2 | - | He's Just Not That Into You | $360,625 | - | - | - | - | $460,287 | 1 | ARM Distribution | true | false |
| 3 | - | Valkyrie | $270,700 | - | - | - | - | $342,813 | 1 | 20th Century Fox International | true | false |
| 4 | 1 | Yes Man | $144,265 | -47.8% | - | - | - | $2,820,527 | 4 | Warner Bros. | false | false |
| 5 | - | Marley & Me | $115,394 | - | - | - | - | $145,020 | - | 20th Century Fox International | - | false |
| 6 | 2 | Seven Pounds | $66,245 | -59.8% | - | - | - | $400,028 | 2 | Walt Disney Studios Sony Pictures Releasing (WDSSPR) | false | false |
| 7 | 4 | Revolutionary Road | $46,498 | -65.1% | - | - | - | $265,537 | 2 | United International Pictures | false | false |
| 8 | 3 | Red Cliff II | $46,095 | -67.7% | - | - | - | $4,186,480 | 5 | 20th Century Fox International | false | false |
| 9 | 7 | Madagascar: Escape 2 Africa | $24,569 | -71.9% | - | - | - | $1,504,981 | 4 | United International Pictures | false | false |
| 10 | 5 | Inkheart | $22,196 | -80.6% | - | - | - | $1,802,596 | 4 | ARM Distribution | false | false |
| 11 | 6 | Bride Wars | $14,122 | -85.5% | - | - | - | $1,114,603 | 4 | 20th Century Fox International | false | false |
| 12 | 8 | Ponyo | $13,680 | -82.3% | - | - | - | $1,067,807 | 4 | Walt Disney Studios Sony Pictures Releasing (WDSSPR) | false | false |
| 13 | - | Frost/Nixon | $9,081 | - | - | - | - | $9,081 | 1 | United International Pictures | true | false |
| 14 | 10 | Detroit Metal City | $5,702 | -49.9% | - | - | - | $396,162 | 5 | N/A | false | false |
| 15 | 9 | Naruto Shippuden: The Movie - Bonds | $4,459 | -81.5% | - | - | - | $224,921 | 3 | N/A | false | false |
| 16 | - | Elsa & Fred | $3,160 | - | - | - | - | $3,917 | 1 | N/A | true | false |
| 17 | 13 | Twilight | $2,831 | +1.7% | - | - | - | $1,771,850 | 10 | N/A | false | false |
| 18 | - | Storm Rider Clash of the Evils | $2,406 | - | - | - | - | $2,768 | 1 | N/A | true | false |
| 19 | 15 | Man on Wire | $489 | -73.7% | - | - | - | $4,713 | 2 | N/A | false | false |
| 20 | 16 | Forever Enthralled | $218 | -46.7% | - | - | - | $531,980 | 9 | N/A | false | false |
| 21 | 12 | 100 Feet | $129 | -97.6% | - | - | - | $11,801 | 2 | Long Shong Entertainment Multimedia Company | false | false |
