| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Bedtime Stories | $374,597 | - | 59 | - | $6,349 | $609,846 | 1 | Walt Disney Pictures | true | false |
| 2 | 1 | Yes Man | $224,698 | -34.1% | 55 | -5 | $4,085 | $2,382,749 | 4 | Warner Bros. | false | false |
| 3 | 2 | The Curious Case of Benjamin Button | $182,435 | -36.9% | 40 | -1 | $4,560 | $696,620 | 2 | N/A | false | false |
| 4 | - | Friday the 13th | $142,112 | - | 38 | - | $3,739 | $142,112 | 1 | N/A | true | false |
| 5 | 3 | Bride Wars | $137,826 | -41.1% | 39 | -2 | $3,534 | $550,529 | 2 | N/A | false | false |
| 6 | 4 | Hotel for Dogs | $60,898 | -58.6% | 40 | -5 | $1,522 | $998,983 | 4 | N/A | false | false |
| 7 | - | Over Her Dead Body | $60,116 | - | 19 | - | $3,164 | $60,116 | 1 | N/A | true | false |
| 8 | 5 | Seven Pounds | $57,480 | -44.4% | 27 | -8 | $2,128 | $1,218,765 | 5 | N/A | false | false |
| 9 | - | Vicky Cristina Barcelona | $28,625 | - | 8 | - | $3,578 | $31,753 | 1 | N/A | true | false |
| 10 | 7 | The Spirit | $17,801 | -67.7% | 22 | -3 | $809 | $115,791 | 2 | N/A | false | false |
| 11 | 10 | Changeling | $17,427 | -46.8% | 14 | -7 | $1,244 | $294,994 | 4 | N/A | false | false |
| 12 | 6 | Marley & Me | $14,834 | -73.5% | 15 | -12 | $988 | $1,112,235 | 5 | N/A | false | false |
| 13 | 8 | Revolutionary Road | $13,973 | -63.3% | 15 | -3 | $931 | $201,049 | 3 | N/A | false | false |
| 14 | 9 | Mad Money | $11,834 | -65% | 7 | -8 | $1,690 | $174,253 | 3 | N/A | false | false |
| 15 | 17 | The Marsh | $10,150 | -13.2% | 7 | - | $1,450 | $322,193 | 6 | N/A | false | false |
| 16 | 11 | Quarantine | $8,763 | -58.3% | 12 | -6 | $730 | $266,391 | 4 | N/A | false | false |
| 17 | 15 | The Abandoned | $7,833 | -46.4% | 4 | -6 | $1,958 | $362,949 | 6 | N/A | false | false |
| 18 | 16 | Free Style | $7,031 | -50.7% | 9 | -8 | $781 | $104,386 | 3 | N/A | false | false |
| 19 | 12 | Twilight | $5,852 | -72% | 5 | -11 | $1,170 | $2,760,753 | 9 | N/A | false | false |
| 20 | 13 | Bolt | $5,275 | -72.2% | 17 | -10 | $310 | $2,229,834 | 9 | N/A | false | false |
| 21 | 14 | Lonely Hearts | $3,715 | -75.7% | 7 | -4 | $530 | $106,678 | 3 | N/A | false | false |
| 22 | 19 | Madagascar: Escape 2 Africa | $2,213 | -72.5% | 9 | -13 | $245 | $5,441,730 | 10 | N/A | false | false |
| 23 | 20 | Bella | $1,723 | -77.5% | 4 | -1 | $430 | $35,662 | 3 | N/A | false | false |
| 24 | 26 | Silent Light | $503 | +62.8% | 1 | - | $503 | $978 | 2 | N/A | false | false |
