| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | The Curious Case of Benjamin Button | $281,237 | - | 24 | - | $11,718 | $281,237 | 1 | N/A | true | false |
| 2 | 1 | The Pink Panther 2 | $144,057 | -59.2% | 17 | -2 | $8,473 | $574,497 | 2 | N/A | false | false |
| 3 | - | Confessions of a Shopaholic | $141,282 | - | 16 | - | $8,830 | $141,282 | 1 | N/A | true | false |
| 4 | - | The Tattooist | $125,551 | - | 16 | - | $7,846 | $125,551 | 1 | N/A | true | false |
| 5 | - | Quarantine | $66,728 | - | 19 | - | $3,512 | $66,728 | 1 | N/A | true | false |
| 6 | 5 | Slumdog Millionaire | $50,170 | -31.3% | 14 | +1 | $3,583 | $918,491 | 5 | Gulf Film | false | false |
| 7 | - | Garfield's Fun Fest | $45,393 | - | 16 | - | $2,837 | $45,393 | 1 | N/A | true | false |
| 8 | 2 | The Unborn | $22,628 | -77.8% | 9 | -10 | $2,514 | $492,949 | 3 | N/A | false | false |
| 9 | 4 | Role Models | $18,651 | -76.1% | 7 | -4 | $2,664 | $119,979 | 2 | N/A | false | false |
| 10 | 10 | Yes Man | $15,430 | -37.6% | 2 | -2 | $7,715 | $703,544 | 5 | N/A | false | false |
| 11 | 3 | Solstice | $15,050 | -85% | 11 | -8 | $1,368 | $139,342 | 2 | N/A | false | false |
| 12 | 7 | Inkheart | $14,276 | -72.6% | 4 | -7 | $3,569 | $265,041 | 3 | N/A | false | false |
| 13 | 8 | The Tale of Despereaux | $14,238 | -63.6% | 6 | -9 | $2,373 | $281,154 | 4 | N/A | false | false |
| 14 | 6 | Appaloosa | $6,108 | -90.1% | 5 | -10 | $1,221 | $82,546 | 2 | N/A | false | false |
| 15 | 19 | Madagascar: Escape 2 Africa | $4,191 | +24.4% | 1 | - | $4,191 | $1,891,532 | 13 | N/A | false | false |
| 16 | 21 | Twilight | $1,457 | -5% | 1 | - | $1,457 | $1,245,509 | 12 | N/A | false | false |
| 17 | 17 | My Mom's New Boyfriend | $1,386 | -73.6% | 1 | -1 | $1,386 | $152,365 | 4 | N/A | false | false |
| 18 | 15 | How to Lose Friends & Alienate People | $1,319 | -83.8% | 1 | -4 | $1,319 | $78,836 | 3 | N/A | false | false |
| 19 | 22 | The Spirit | $1,307 | +3.6% | 1 | - | $1,307 | $271,519 | 4 | N/A | false | false |
| 20 | 18 | Revolutionary Road | $1,228 | -74.4% | 1 | - | $1,228 | $120,826 | 5 | N/A | false | false |
| 21 | 13 | Hosh Ala Wakah Mink | $645 | -95.3% | 1 | -7 | $645 | $18,644 | 2 | N/A | false | false |
