| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | The Curious Case of Benjamin Button | $307,300 | -0.3% | 65 | +13 | $4,727 | $1,425,185 | 3 | Warner Bros. | false | false |
| 2 | 2 | Bedtime Stories | $299,104 | +6.6% | 68 | -1 | $4,398 | $1,384,613 | 3 | Walt Disney Pictures | false | false |
| 3 | - | Hotel for Dogs | $197,850 | - | 40 | - | $4,946 | $197,850 | 1 | Paramount Pictures International | true | false |
| 4 | 3 | Valkyrie | $181,587 | -12.4% | 59 | -4 | $3,077 | $472,194 | 2 | 20th Century Fox International | false | false |
| 5 | 4 | Slumdog Millionaire | $158,272 | +31.6% | 41 | - | $3,860 | $324,854 | 2 | Distribution Company | false | false |
| 6 | 6 | Vicky Cristina Barcelona | $108,312 | +5% | 34 | - | $3,185 | $485,230 | 3 | Pachamama Cine | false | false |
| 7 | - | The Wrestler | $91,694 | - | 30 | - | $3,056 | $91,694 | 1 | Distribution Company | true | false |
| 8 | 9 | Bolt | $91,494 | +29.4% | 84 | -37 | $1,089 | $2,205,311 | 6 | Walt Disney Pictures | false | false |
| 9 | - | The Pink Panther 2 | $81,021 | - | 27 | - | $3,000 | $81,021 | 1 | Sony Pictures Releasing | true | false |
| 10 | 5 | Friday the 13th | $76,815 | -35.5% | 30 | -2 | $2,560 | $227,398 | 2 | Paramount Pictures International | false | false |
| 11 | 7 | Yes Man | $69,810 | -14% | 54 | -3 | $1,292 | $1,245,378 | 6 | Warner Bros. | false | false |
| 12 | 11 | Changeling | $53,970 | +1% | 44 | -3 | $1,226 | $825,097 | 5 | Universal Pictures International (UPI) | false | false |
| 13 | 8 | Underworld: Rise of the Lycans | $52,980 | -25.6% | 30 | - | $1,766 | $306,358 | 3 | Sony Pictures Releasing | false | false |
| 14 | 10 | Milk | $38,704 | -29.7% | 27 | -6 | $1,433 | $118,956 | 2 | Universal Pictures International (UPI) | false | false |
| 15 | 14 | Doubt | $33,908 | +43% | 23 | -3 | $1,474 | $495,795 | 6 | Walt Disney Pictures | false | false |
| 16 | 16 | Revolutionary Road | $24,949 | +40.1% | 23 | -8 | $1,084 | $265,338 | 4 | Paramount Pictures International | false | false |
| 17 | - | Frost/Nixon | $23,548 | - | 15 | - | $1,569 | $23,548 | 1 | United International Pictures | true | false |
| 18 | 12 | Marley & Me | $20,182 | -35.7% | 50 | -3 | $403 | $650,013 | 5 | 20th Century Fox International | false | false |
| 19 | 13 | The Tale of Despereaux | $14,393 | -45.3% | 37 | -19 | $389 | $167,869 | 3 | United International Pictures | false | false |
| 20 | 17 | Australia | $12,894 | -20.9% | 32 | -11 | $402 | $831,421 | 7 | 20th Century Fox International | false | false |
| 21 | 15 | Inkheart | $9,145 | -52.3% | 32 | -16 | $285 | $361,011 | 4 | Distribution Company | false | false |
| 22 | 18 | Twilight | $6,867 | -51.9% | 15 | -20 | $457 | $1,875,471 | 8 | Alfa Films | false | false |
| 23 | 22 | Bangkok Dangerous | $4,571 | +92.1% | 9 | -4 | $507 | $122,724 | 6 | Distribution Company | false | false |
| 24 | 20 | Madagascar: Escape 2 Africa | $3,868 | -13.3% | 14 | -22 | $276 | $5,523,607 | 12 | Paramount Pictures International | false | false |
| 25 | 25 | Body of Lies | $2,693 | +76.5% | 6 | -1 | $448 | $928,011 | 13 | Warner Bros. | false | false |
| 26 | 19 | The Day the Earth Stood Still | $1,361 | -82.4% | 9 | -10 | $151 | $1,953,644 | 8 | 20th Century Fox International | false | false |
| 27 | 34 | El ratón Pérez 2 | $1,357 | +302.7% | 6 | - | $226 | $708,780 | 8 | Walt Disney Pictures | false | false |
| 28 | - | Aniceto | $1,336 | - | 3 | - | $445 | $139,544 | 37 | Primer Plano Film Group | false | false |
| 29 | 30 | Rudo y Cursi | $887 | +49.6% | 4 | - | $221 | $314,144 | 7 | United International Pictures | false | false |
| 30 | 26 | The Duchess | $883 | -40.3% | 5 | -1 | $176 | $259,410 | 11 | United International Pictures | false | false |
| 31 | 21 | Emma's Bliss | $849 | -68.2% | 3 | -1 | $283 | $26,554 | 4 | Primer Plano Film Group | false | false |
| 32 | 31 | Che: Part One | $765 | +30.3% | 3 | +1 | $255 | $662,838 | 15 | Alfa Films | false | false |
| 33 | 54 | RocknRolla | $570 | +6,233.3% | 1 | -1 | $570 | $91,687 | 11 | Warner Bros. | false | false |
| 34 | 37 | La próxima estación | $477 | +90.8% | 2 | - | $238 | $122,592 | 25 | Primer Plano Film Group | false | false |
| 35 | 35 | U2 3D | $463 | +55.4% | 1 | - | $463 | $143,112 | 48 | IMAX | false | false |
| 36 | 43 | The Camera Obscura 2008 Re-release | $430 | +405.9% | 1 | - | $430 | $65,299 | 19 | Distribution Company | false | false |
| 37 | 32 | Four Christmases | $424 | -23.6% | 1 | -1 | $424 | $421,009 | 10 | Distribution Company | false | false |
| 38 | 33 | W. | $404 | -11.6% | 3 | -2 | $134 | $66,497 | 6 | Impacto Cine | false | false |
| 39 | 23 | Blame it on Fidel | $314 | -86.2% | 1 | -3 | $314 | $33,998 | 5 | Zeta Films | false | false |
| 40 | 44 | The Pope's Toilet | $287 | +258.8% | 2 | +1 | $143 | $28,649 | 8 | Primer Plano Film Group | false | false |
| 41 | - | A Boyfriend for My Wife | $248 | - | 1 | - | $248 | $5,655,910 | 28 | Walt Disney Pictures | false | false |
| 42 | 48 | My Mom's New Boyfriend | $243 | +262.7% | 1 | - | $243 | $147,254 | 15 | - | false | false |
| 43 | 49 | Café de los maestros | $222 | +416.3% | 1 | - | $222 | $96,146 | 35 | Alfa Films | false | false |
| 44 | 29 | Death Sentence | $213 | -65.1% | 1 | - | $213 | $186,418 | 12 | Distribution Company | false | false |
| 45 | - | Death Defying Acts | $203 | - | 1 | - | $203 | $118,548 | 13 | Alfa Films | false | false |
| 46 | - | The Boy in the Striped Pajamas | $201 | - | 1 | - | $201 | $86,175 | 12 | Walt Disney Pictures | false | false |
| 47 | - | Reasons for Not Falling in Love | $148 | - | 1 | - | $148 | $542,931 | 25 | Distribution Company | false | false |
| 48 | 38 | Late Bloomers | $142 | -19.8% | 1 | -1 | $142 | $79,581 | 13 | Primer Plano Film Group | false | false |
| 49 | 28 | Righteous Kill | $114 | -87.8% | 1 | -1 | $114 | $579,003 | 14 | CDI Films | false | false |
| 50 | - | Elegy | $92 | - | 1 | - | $92 | $175,398 | 14 | Distribution Company | false | false |
| 51 | - | Bug | $86 | - | 1 | - | $86 | $6,619 | 6 | Alfa Films | false | false |
| 52 | - | Planet Terror | $50 | - | 1 | - | $50 | $94,001 | 11 | Pachamama Cine | false | false |
| 53 | - | Saw V | $39 | - | 1 | - | $39 | $1,076,593 | 17 | Walt Disney Pictures | false | false |
