| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | He's Just Not That Into You | $93,095 | -47.4% | 50 | - | $1,861 | $325,741 | 2 | NuMetro Distribution | false | false |
| 2 | 3 | Bedtime Stories | $57,038 | -25.7% | 55 | +4 | $1,037 | $385,018 | 4 | Ster-Kinekor Pictures | false | false |
| 3 | - | Inkheart | $48,343 | - | 40 | - | $1,208 | $48,343 | 1 | NuMetro Distribution | true | false |
| 4 | 4 | Bride Wars | $46,936 | -32.9% | 61 | +1 | $769 | $619,494 | 5 | NuMetro Distribution | false | false |
| 5 | 2 | Seven Pounds | $46,212 | -43.6% | 50 | - | $924 | $155,854 | 2 | Ster-Kinekor Pictures | false | false |
| 6 | - | Changeling | $41,891 | - | 29 | - | $1,444 | $41,891 | 1 | United International Pictures | true | false |
| 7 | - | Notorious | $28,995 | - | 25 | - | $1,159 | $28,995 | 1 | NuMetro Distribution | true | false |
| 8 | 5 | Transporter 3 | $26,758 | -45.5% | 56 | -9 | $477 | $667,880 | 6 | United International Pictures | false | false |
| 9 | 6 | Role Models | $24,671 | -46.9% | 39 | -5 | $632 | $157,467 | 3 | United International Pictures | false | false |
| 10 | 7 | Valkyrie | $22,202 | -46.3% | 48 | -2 | $462 | $296,298 | 4 | NuMetro Distribution | false | false |
| 11 | 8 | The Secret Life of Bees | $16,312 | -44.8% | 24 | - | $679 | $104,747 | 3 | NuMetro Distribution | false | false |
| 12 | - | The Wrestler | $15,982 | - | 13 | - | $1,229 | $15,982 | 1 | United International Pictures | true | false |
| 13 | 9 | Yes Man | $13,925 | -47% | 34 | -7 | $409 | $863,630 | 8 | NuMetro Distribution | false | false |
| 14 | 10 | Billu | $13,881 | -37.3% | 5 | - | $2,776 | $40,872 | 2 | NuMetro Distribution | false | false |
| 15 | - | Delhi-6 | $10,991 | - | 8 | - | $1,373 | $10,991 | 1 | N/A | true | false |
| 16 | 14 | Doubt | $10,666 | -31% | 9 | -2 | $1,185 | $59,452 | 3 | Ster-Kinekor Pictures | false | false |
| 17 | 15 | The Duchess | $10,082 | -32.6% | 12 | - | $840 | $100,762 | 4 | Ster-Kinekor Pictures | false | false |
| 18 | 11 | Mr. Bones 2: Back from the Past | $8,745 | -54.6% | 23 | -5 | $380 | $3,614,391 | 13 | United International Pictures | false | false |
| 19 | 16 | Revolutionary Road | $8,078 | -43.3% | 18 | - | $448 | $164,921 | 5 | United International Pictures | false | false |
| 20 | 18 | Bolt | $7,760 | -12.7% | 17 | -3 | $456 | $920,712 | 9 | Ster-Kinekor Pictures | false | false |
| 21 | 22 | Four Christmases | $6,306 | +3.1% | 19 | -11 | $331 | $499,925 | 7 | NuMetro Distribution | false | false |
| 22 | 17 | Burn After Reading | $6,219 | -37.1% | 11 | -4 | $565 | $289,980 | 7 | Ster-Kinekor Pictures | false | false |
| 23 | 27 | Appaloosa | $4,604 | +277.7% | 10 | +5 | $460 | $17,378 | 2 | NuMetro Distribution | false | false |
| 24 | 24 | Madagascar: Escape 2 Africa | $3,573 | -23.6% | 11 | +1 | $324 | $2,092,673 | 12 | United International Pictures | false | false |
| 25 | 25 | Frost/Nixon | $3,439 | -16.9% | 3 | -5 | $1,146 | $36,093 | 4 | United International Pictures | false | false |
| 26 | 20 | Happy-Go-Lucky | $2,905 | -55.1% | 5 | -5 | $581 | $25,866 | 3 | United International Pictures | false | false |
| 27 | - | The Tale of Despereaux | $2,484 | - | 8 | - | $310 | $288,058 | 8 | United International Pictures | false | false |
| 28 | 21 | Killshot | $1,997 | -68.6% | 7 | -7 | $285 | $89,311 | 5 | Ster-Kinekor Pictures | false | false |
| 29 | - | Igor | $1,990 | - | 9 | - | $221 | $33,910 | 5 | Ster-Kinekor Pictures | false | false |
| 30 | - | Pride and Glory | $1,859 | - | 3 | - | $619 | $221,604 | 8 | NuMetro Distribution | false | false |
