| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Marley & Me | $474,313 | - | 88 | - | $5,389 | $474,313 | 1 | 20th Century Fox International | true | false |
| 2 | 2 | Gran Torino | $419,404 | +41.7% | 50 | +27 | $8,388 | $797,883 | 2 | Warner Bros. | false | false |
| 3 | 1 | Slumdog Millionaire | $356,879 | -14.3% | 36 | +1 | $9,913 | $3,045,942 | 9 | Pathé | false | false |
| 4 | 26 | The Reader | $256,178 | +4,693.8% | 30 | +29 | $8,539 | $280,031 | 3 | Ascot Elite Entertainment Group | false | false |
| 5 | - | Watchmen | $245,838 | - | 52 | - | $4,727 | $245,838 | 1 | N/A | true | false |
| 6 | 7 | Milk | $127,256 | +18.8% | 32 | +8 | $3,976 | $494,233 | 7 | Ascot Elite Entertainment Group | false | false |
| 7 | 4 | Yes Man | $123,743 | -41.8% | 29 | -14 | $4,267 | $1,108,710 | 9 | Warner Bros. | false | false |
| 8 | 3 | The Curious Case of Benjamin Button | $114,281 | -50.4% | 38 | -19 | $3,007 | $2,802,462 | 6 | Warner Bros. | false | false |
| 9 | 5 | Twilight | $101,719 | -33.6% | 39 | -24 | $2,608 | $2,765,629 | 16 | Ascot Elite Entertainment Group | false | false |
| 10 | 6 | He's Just Not That Into You | $90,681 | -36.2% | 29 | -7 | $3,126 | $710,723 | 4 | Warner Bros. | false | false |
| 11 | 9 | Hotel for Dogs | $86,634 | +1.9% | 47 | +9 | $1,843 | $765,629 | 5 | Universal Pictures International (UPI) | false | false |
| 12 | 10 | Lilly the Witch: The Dragon and the Magic Book | $80,249 | -2.4% | 45 | +1 | $1,783 | $337,285 | 3 | Walt Disney Pictures | false | false |
| 13 | 8 | Bolt | $59,358 | -44.5% | 51 | -9 | $1,163 | $1,720,288 | 15 | Walt Disney Pictures | false | false |
| 14 | 12 | The Wrestler | $52,333 | -35% | 20 | - | $2,616 | $214,901 | 3 | Frenetic Films | false | false |
| 15 | 17 | Home | $48,161 | +4.2% | 12 | +3 | $4,013 | $736,298 | 21 | Filmcoopi | false | false |
| 16 | 15 | Revolutionary Road | $40,261 | -36.6% | 23 | -10 | $1,750 | $2,158,797 | 8 | Universal Pictures International (UPI) | false | false |
| 17 | 11 | The International | $38,263 | -52.6% | 16 | -12 | $2,391 | $564,217 | 4 | Walt Disney Pictures | false | false |
| 18 | 14 | Killing is My Business, Honey | $36,160 | -52% | 18 | -4 | $2,008 | $125,507 | 2 | Warner Bros. | false | false |
| 19 | 13 | Role Models | $30,192 | -61.7% | 27 | -2 | $1,118 | $119,769 | 2 | Universal Pictures International (UPI) | false | false |
| 20 | 18 | Marcello Marcello | $27,998 | -31.5% | 12 | - | $2,333 | $397,378 | 29 | Filmcoopi | false | false |
| 21 | 19 | Australia | $26,348 | -31.3% | 11 | -6 | $2,395 | $5,186,928 | 11 | 20th Century Fox International | false | false |
| 22 | 23 | The Pink Panther 2 | $15,559 | -31.1% | 7 | -6 | $2,222 | $88,773 | 3 | Walt Disney Pictures | false | false |
| 23 | 25 | Changeling | $11,824 | -26.7% | 11 | +1 | $1,074 | $1,451,132 | 17 | Universal Pictures International (UPI) | false | false |
| 24 | 22 | Frost/Nixon | $8,654 | -63.7% | 4 | -11 | $2,163 | $163,894 | 4 | Universal Pictures International (UPI) | false | false |
| 25 | 24 | The Tale of Despereaux | $8,499 | -47.4% | 12 | -4 | $708 | $83,397 | 4 | Universal Pictures International (UPI) | false | false |
| 26 | - | Madagascar: Escape 2 Africa | $7,647 | - | 13 | - | $588 | $11,008,273 | 14 | Universal Pictures International (UPI) | false | false |
| 27 | 27 | Fly Me to the Moon 3D | $3,607 | +45.8% | 1 | - | $3,607 | $114,439 | 19 | N/A | false | false |
| 28 | 29 | Burn After Reading | $1,610 | -15.7% | 2 | - | $805 | $3,021,453 | 25 | Ascot Elite Entertainment Group | false | false |
