| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Gran Torino | $428,145 | - | 31 | - | $13,811 | $428,145 | 1 | Roadshow Films | true | false |
| 2 | - | Guiness | $227,760 | - | 51 | - | $4,465 | $227,760 | 1 | Village Films | true | false |
| 3 | 2 | Valkyrie | $199,356 | -38% | 40 | -5 | $4,983 | $634,104 | 2 | Odeon | false | false |
| 4 | 1 | The Pink Panther 2 | $174,733 | -53.8% | 66 | -11 | $2,647 | $1,579,677 | 3 | Sony Pictures Releasing | false | false |
| 5 | 4 | Eden Is West | $165,871 | -22.2% | - | - | - | $492,750 | 2 | Odeon | false | false |
| 6 | - | Push | $121,293 | - | 16 | - | $7,580 | $121,293 | 1 | Odeon | true | false |
| 7 | 3 | He's Just Not That Into You | $110,008 | -50% | 27 | +2 | $4,074 | $417,011 | 2 | Village Films | false | false |
| 8 | 7 | Bolt | $81,424 | -13.2% | 66 | -3 | $1,233 | $777,778 | 4 | Audio Visual Enterprises | false | false |
| 9 | 10 | The Reader | $81,008 | +15.8% | 14 | - | $5,786 | $1,508,231 | 8 | Odeon | false | false |
| 10 | - | The Tale of Despereaux | $75,997 | - | 32 | - | $2,374 | $75,997 | 1 | United International Pictures | true | false |
| 11 | 5 | The Unborn | $66,826 | -46.4% | 16 | +1 | $4,176 | $260,119 | 2 | United International Pictures | false | false |
| 12 | - | Seven Pounds | $64,217 | - | 16 | - | $4,013 | $64,217 | 1 | Sony Pictures Releasing | true | false |
| 13 | 8 | The Dust of Time | $54,717 | -29.5% | 15 | - | $3,647 | $355,842 | 3 | Audio Visual Enterprises | false | false |
| 14 | 6 | I'm Dying for You! | $44,523 | -57.3% | 19 | -17 | $2,343 | $2,058,699 | 5 | Odeon | false | false |
| 15 | 16 | Milk | $36,683 | +105.6% | 14 | - | $2,620 | $670,228 | 7 | Odeon | false | false |
| 16 | 11 | My Bloody Valentine | $32,631 | -47.9% | 8 | - | $4,078 | $124,206 | 2 | Spentzos Films | false | false |
| 17 | 9 | The Curious Case of Benjamin Button | $28,470 | -61.4% | 22 | -21 | $1,294 | $4,106,250 | 6 | Village Films | false | false |
| 18 | 12 | The Wrestler | $28,350 | -53.9% | 21 | - | $1,350 | $532,071 | 4 | Spentzos Films | false | false |
| 19 | - | Flame & Citron | $25,185 | - | 3 | - | $8,395 | $25,185 | 1 | - | true | false |
| 20 | 13 | Doubt | $20,214 | -64.1% | 6 | -4 | $3,369 | $666,669 | 5 | Audio Visual Enterprises | false | false |
| 21 | 14 | Rachel Getting Married | $10,234 | -67.7% | 5 | -1 | $2,046 | $51,045 | 2 | Audio Visual Enterprises | false | false |
| 22 | 18 | Madagascar: Escape 2 Africa | $10,032 | -40.7% | 20 | -7 | $501 | $3,289,893 | 11 | United International Pictures | false | false |
| 23 | 15 | Underworld: Rise of the Lycans | $4,716 | -82.4% | 12 | -13 | $393 | $1,218,300 | 6 | Audio Visual Enterprises | false | false |
| 24 | - | Minor Freedoms | $2,497 | - | 1 | - | $2,497 | $2,497 | 1 | Odeon | true | false |
| 25 | 17 | Frost/Nixon | $2,322 | -86.8% | 2 | -5 | $1,161 | $86,144 | 3 | United International Pictures | false | false |
| 26 | 27 | Changeling | $1,420 | -51.6% | 3 | - | $473 | $1,574,374 | 13 | United International Pictures | false | false |
| 27 | 24 | Fly Me to the Moon 3D | $1,329 | -62.1% | 4 | -5 | $332 | $502,137 | 16 | Odeon | false | false |
