| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Bedtime Stories | $366,477 | -3.4% | 60 | +1 | $6,107 | $2,077,753 | 3 | Walt Disney Pictures | false | false |
| 2 | 2 | Valkyrie | $217,167 | -18.4% | 61 | +1 | $3,560 | $833,885 | 2 | N/A | false | false |
| 3 | 3 | The Curious Case of Benjamin Button | $149,480 | -20.7% | 40 | +2 | $3,737 | $1,404,754 | 4 | N/A | false | false |
| 4 | 5 | Yes Man | $132,987 | -21.2% | 49 | -3 | $2,714 | $3,045,397 | 6 | Warner Bros. | false | false |
| 5 | 4 | The Pink Panther 2 | $115,880 | -36.4% | 55 | +9 | $2,106 | $504,095 | 2 | Sony Pictures Releasing | false | false |
| 6 | - | Slumdog Millionaire | $106,994 | - | 11 | - | $9,726 | $148,778 | 1 | N/A | true | false |
| 7 | 6 | Friday the 13th | $84,167 | -14.6% | 11 | -29 | $7,651 | $582,508 | 3 | N/A | false | false |
| 8 | - | Doubt | $59,488 | - | 16 | - | $3,718 | $89,525 | 1 | Walt Disney Pictures | true | false |
| 9 | 7 | Bride Wars | $55,050 | -30.4% | 17 | -10 | $3,238 | $887,242 | 4 | N/A | false | false |
| 10 | - | Death Sentence | $54,923 | - | 16 | - | $3,432 | $71,705 | 1 | N/A | true | false |
| 11 | 9 | Over Her Dead Body | $41,217 | +19.1% | 20 | +1 | $2,060 | $227,357 | 3 | N/A | false | false |
| 12 | - | .45 | $29,572 | - | 10 | - | $2,957 | $32,641 | 1 | N/A | true | false |
| 13 | 8 | Wild Child | $27,145 | -46.1% | 20 | - | $1,357 | $149,688 | 2 | N/A | false | false |
| 14 | 11 | Hotel for Dogs | $26,881 | -3.5% | 29 | +2 | $926 | $1,126,381 | 6 | N/A | false | false |
| 15 | 10 | Vicky Cristina Barcelona | $26,576 | -13.2% | 7 | - | $3,796 | $157,312 | 3 | N/A | false | false |
| 16 | 23 | Quarantine | $13,601 | +3,960% | 10 | +8 | $1,360 | $282,392 | 6 | N/A | false | false |
| 17 | 12 | Seven Pounds | $12,784 | -8.6% | 10 | -2 | $1,278 | $1,301,878 | 7 | N/A | false | false |
| 18 | 19 | Mad Money | $10,423 | +494.6% | 10 | +4 | $1,042 | $204,545 | 5 | N/A | false | false |
| 19 | 13 | Changeling | $7,750 | +9% | 4 | +1 | $1,937 | $332,094 | 6 | N/A | false | false |
| 20 | 16 | The Marsh | $3,268 | -12.6% | 7 | +3 | $466 | $345,423 | 8 | N/A | false | false |
| 21 | 20 | Twilight | $1,739 | +72.5% | 2 | - | $869 | $2,766,971 | 11 | N/A | false | false |
| 22 | 14 | The Spirit | $1,490 | -65.7% | 6 | -4 | $248 | $143,887 | 4 | N/A | false | false |
| 23 | 15 | Revolutionary Road | $475 | -87.4% | 2 | -6 | $237 | $221,331 | 5 | N/A | false | false |
