| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Gran Torino | $208,862 | - | 44 | - | $4,746 | $208,862 | 1 | Warner Bros. | true | false |
| 2 | - | He's Just Not That Into You | $188,519 | - | 31 | - | $6,081 | $188,519 | 1 | Distribution Company | true | false |
| 3 | - | Watchmen | $183,933 | - | 45 | - | $4,087 | $183,933 | 1 | Paramount Pictures International | true | false |
| 4 | 1 | Slumdog Millionaire | $163,968 | -25.4% | 47 | +3 | $3,488 | $882,127 | 4 | Distribution Company | false | false |
| 5 | 2 | Bedtime Stories | $132,503 | -22.8% | 79 | +3 | $1,677 | $1,808,475 | 5 | Walt Disney Pictures | false | false |
| 6 | 3 | The Curious Case of Benjamin Button | $123,394 | -22.6% | 71 | +11 | $1,737 | $1,805,395 | 5 | Warner Bros. | false | false |
| 7 | 4 | Bride Wars | $80,789 | -24.3% | 43 | +1 | $1,878 | $236,198 | 2 | 20th Century Fox International | false | false |
| 8 | 5 | Hotel for Dogs | $67,024 | -30.4% | 41 | -2 | $1,634 | $445,922 | 3 | Paramount Pictures International | false | false |
| 9 | 8 | Seven Pounds | $53,582 | -24.6% | 28 | - | $1,913 | $152,344 | 2 | Sony Pictures Releasing | false | false |
| 10 | 6 | Valkyrie | $52,124 | -41.9% | 67 | +1 | $777 | $680,594 | 4 | 20th Century Fox International | false | false |
| 11 | 7 | Vicky Cristina Barcelona | $48,593 | -39.6% | 32 | -7 | $1,518 | $667,468 | 5 | Pachamama Cine | false | false |
| 12 | 9 | The Pink Panther 2 | $34,838 | -22.9% | 25 | - | $1,393 | $199,075 | 3 | Sony Pictures Releasing | false | false |
| 13 | 10 | Friday the 13th | $27,186 | -23.8% | 30 | -1 | $906 | $321,740 | 4 | Paramount Pictures International | false | false |
| 14 | 12 | Milk | $23,527 | -32.7% | 33 | +1 | $712 | $210,494 | 4 | Universal Pictures International (UPI) | false | false |
| 15 | - | Lovely Loneliness | $23,497 | - | 11 | - | $2,136 | $23,497 | 1 | Pachamama Cine | true | false |
| 16 | 14 | Yes Man | $20,816 | -39.4% | 47 | -7 | $442 | $298,593 | 8 | Warner Bros. | false | false |
| 17 | 11 | Changeling | $17,249 | -51.6% | 39 | -8 | $442 | $888,468 | 7 | Universal Pictures International (UPI) | false | false |
| 18 | 13 | The Wrestler | $16,421 | -52.9% | 30 | - | $547 | $177,858 | 3 | Distribution Company | false | false |
| 19 | 17 | Doubt | $8,499 | -52.2% | 17 | -6 | $499 | $521,899 | 8 | Walt Disney Pictures | false | false |
| 20 | 15 | Underworld: Rise of the Lycans | $8,401 | -66.6% | 16 | -5 | $525 | $369,378 | 5 | Sony Pictures Releasing | false | false |
| 21 | - | Unfair Competition 2009 Re-release | $8,352 | - | 4 | - | $2,088 | $8,352 | 1 | Primer Plano Film Group | true | false |
| 22 | 19 | Revolutionary Road | $4,683 | -63.4% | 18 | -9 | $260 | $289,868 | 6 | Paramount Pictures International | false | false |
| 23 | 16 | Death Proof | $4,666 | -75.2% | 13 | -1 | $358 | $31,231 | 2 | Pachamama Cine | false | false |
| 24 | - | Rodney | $3,539 | - | 14 | - | $252 | $3,539 | 1 | Primer Plano Film Group | true | false |
| 25 | 21 | L'année suivante | $2,967 | -52.1% | 3 | +1 | $989 | $10,738 | 2 | Zeta Films | false | false |
| 26 | 18 | Bolt | $2,943 | -80.7% | 29 | -38 | $101 | $2,181,926 | 8 | Walt Disney Pictures | false | false |
| 27 | 28 | Journey to the Center of the Earth | $2,393 | +52.6% | 1 | - | $2,393 | $1,311,200 | 34 | Distribution Company | false | false |
| 28 | 23 | Frost/Nixon | $2,072 | -59.9% | 6 | -1 | $345 | $41,017 | 3 | United International Pictures | false | false |
| 29 | 22 | Marley & Me | $2,033 | -62.6% | 12 | -14 | $169 | $637,515 | 7 | 20th Century Fox International | false | false |
| 30 | 27 | Twilight | $1,599 | -17.2% | 7 | -5 | $228 | $1,842,730 | 10 | Alfa Films | false | false |
| 31 | 24 | Inkheart | $1,526 | -59.6% | 12 | -19 | $127 | $363,236 | 6 | Distribution Company | false | false |
| 32 | 20 | The Tale of Despereaux | $1,506 | -79.6% | 14 | -23 | $107 | $178,167 | 5 | United International Pictures | false | false |
| 33 | 26 | Am Ende kommen Touristen | $1,196 | -63.2% | 4 | - | $299 | $13,543 | 3 | Alfa Films | false | false |
| 34 | - | High School Musical 3: Senior Year | $667 | - | 3 | - | $222 | $1,313,844 | 15 | Walt Disney Pictures | false | false |
| 35 | 31 | U2 3D | $558 | -39.3% | 1 | - | $558 | $140,453 | 50 | IMAX | false | false |
| 36 | 25 | Australia | $551 | -83.8% | 8 | -7 | $68 | $817,847 | 9 | 20th Century Fox International | false | false |
| 37 | 32 | Aniceto | $482 | -39.1% | 1 | -1 | $482 | $137,378 | 39 | Primer Plano Film Group | false | false |
| 38 | 29 | The Day the Earth Stood Still | $476 | -53.1% | 5 | -6 | $95 | $1,896,453 | 10 | 20th Century Fox International | false | false |
| 39 | 34 | Che: Part One | $450 | -28% | 2 | -3 | $225 | $649,260 | 17 | Alfa Films | false | false |
| 40 | 39 | The Camera Obscura 2008 Re-release | $285 | -15.2% | 2 | +1 | $142 | $64,068 | 21 | Distribution Company | false | false |
| 41 | 35 | Blame it on Fidel | $283 | -48.5% | 1 | -1 | $283 | $35,751 | 7 | Zeta Films | false | false |
| 42 | 30 | Madagascar: Escape 2 Africa | $236 | -74.6% | 5 | -7 | $47 | $5,228,408 | 14 | Paramount Pictures International | false | false |
| 43 | 36 | El ratón Pérez 2 | $106 | -73.6% | 1 | -4 | $106 | $702,422 | 10 | Walt Disney Pictures | false | false |
| 44 | 37 | Emma's Bliss | $105 | -72.9% | 1 | -1 | $105 | $26,680 | 6 | Primer Plano Film Group | false | false |
| 45 | 42 | Body of Lies | $75 | -68.9% | 1 | - | $75 | $930,022 | 15 | Warner Bros. | false | false |
| 46 | 43 | Late Bloomers | $66 | -56% | 1 | - | $66 | $77,398 | 15 | Primer Plano Film Group | false | false |
| 47 | 46 | W. | $29 | -79.3% | 1 | -2 | $29 | $65,346 | 8 | Impacto Cine | false | false |
| 48 | 44 | Fly Me to the Moon 3D | $26 | -82.1% | 1 | -1 | $26 | $127,382 | 12 | Distribution Company | false | false |
| 49 | 33 | The Duchess | $22 | -96.6% | 1 | -4 | $22 | $263,387 | 13 | United International Pictures | false | false |
| 50 | 48 | The Pope's Toilet | $22 | -80.2% | 1 | - | $22 | $28,065 | 10 | Primer Plano Film Group | false | false |
| 51 | 54 | Saw V | $20 | -41.2% | 2 | - | $10 | $1,076,699 | 19 | Walt Disney Pictures | false | false |
