| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Watchmen | $2,293,099 | - | 355 | - | $6,459 | $2,293,099 | 1 | Paramount Pictures International | true | false |
| 2 | 1 | He's Just Not That Into You | $669,592 | -33.3% | 250 | -2 | $2,678 | $7,937,832 | 4 | Roadshow Films | false | false |
| 3 | 2 | Slumdog Millionaire | $613,687 | -31.9% | 207 | +11 | $2,964 | $10,496,307 | 12 | Icon Film Distribution | false | false |
| 4 | 3 | Gran Torino | $459,330 | -24.7% | 203 | -2 | $2,262 | $8,395,907 | 7 | Roadshow Films | false | false |
| 5 | - | New in Town | $323,171 | - | 167 | - | $1,935 | $323,171 | 1 | Icon Film Distribution | true | false |
| 6 | 6 | Last Chance Harvey | $297,563 | -23% | 144 | +4 | $2,066 | $895,213 | 2 | Icon Film Distribution | false | false |
| 7 | 4 | The Unborn | $296,656 | -45.7% | 123 | -2 | $2,411 | $1,000,195 | 2 | Universal Pictures International (UPI) | false | false |
| 8 | 7 | The Reader | $258,539 | -21.9% | 53 | - | $4,878 | $1,310,123 | 3 | Roadshow Films | false | false |
| 9 | 5 | The International | $218,038 | -50.4% | 213 | -16 | $1,023 | $1,736,599 | 3 | Sony Pictures Releasing | false | false |
| 10 | 8 | Ghost Town | $138,621 | -54% | 172 | -26 | $805 | $2,307,552 | 4 | Paramount Pictures International | false | false |
| 11 | 9 | Zack and Miri Make a Porno | $122,102 | -52.9% | 120 | -10 | $1,017 | $1,162,777 | 3 | Roadshow Films | false | false |
| 12 | 12 | The Combination | $97,540 | -18.8% | 34 | +2 | $2,868 | $269,263 | 2 | - | false | false |
| 13 | 10 | Changeling | $93,512 | -45.8% | 92 | -35 | $1,016 | $2,301,252 | 5 | Universal Pictures International (UPI) | false | false |
| 14 | 13 | Twilight | $82,201 | -28% | 68 | -20 | $1,208 | $13,599,391 | 14 | Hoyts Distribution | false | false |
| 15 | 14 | Hotel for Dogs | $82,022 | -20.7% | 139 | -17 | $590 | $3,963,823 | 8 | Paramount Pictures International | false | false |
| 16 | - | The Secret Life of Bees | $76,660 | - | 44 | - | $1,742 | $100,850 | 1 | 20th Century Fox International | true | false |
| 17 | 15 | Australia | $60,535 | -40.5% | 74 | -39 | $818 | $23,376,203 | 15 | 20th Century Fox International | false | false |
| 18 | 17 | Milk | $52,112 | -34.3% | 42 | -3 | $1,240 | $1,037,118 | 6 | Universal Pictures International (UPI) | false | false |
| 19 | - | Dean Spanley 2008 Re-release | $49,498 | - | 34 | - | $1,455 | $56,782 | 1 | Paramount Pictures International | true | false |
| 20 | 18 | Bride Wars | $45,626 | -40% | 50 | -54 | $912 | $7,209,569 | 8 | 20th Century Fox International | false | false |
| 21 | 19 | Underworld: Rise of the Lycans | $25,201 | -60.7% | 48 | -29 | $525 | $3,224,238 | 7 | Sony Pictures Releasing | false | false |
| 22 | 20 | W. | $23,862 | -60.2% | 48 | -4 | $497 | $133,018 | 2 | Hoyts Distribution | false | false |
| 23 | - | Easy Virtue | $21,613 | - | 47 | - | $459 | $21,613 | - | Hopscotch Films | - | false |
| 24 | - | Love the Beast | $20,857 | - | 48 | - | $434 | $20,857 | - | Madman Entertainment | - | false |
| 25 | 21 | Marley & Me | $18,137 | -64.3% | 28 | -21 | $647 | $6,406,390 | 10 | 20th Century Fox International | false | false |
| 26 | 24 | Rachel Getting Married | $17,030 | -61.5% | 28 | -15 | $608 | $409,285 | 4 | Sony Pictures Releasing | false | false |
| 27 | - | Beautiful | $14,340 | - | 19 | - | $754 | $14,340 | 1 | Jump Street Films | true | false |
| 28 | 28 | Revolutionary Road | $13,564 | -47% | 35 | -12 | $387 | $1,975,421 | 7 | Paramount Pictures International | false | false |
| 29 | 23 | Valkyrie | $13,029 | -72.5% | 38 | -37 | $342 | $3,980,525 | 7 | 20th Century Fox International | false | false |
| 30 | 25 | Role Models | $10,995 | -74.6% | 24 | -44 | $458 | $4,302,190 | 8 | Universal Pictures International (UPI) | false | false |
| 31 | 33 | The Tale of Despereaux | $10,061 | +6.2% | 26 | +3 | $386 | $1,559,680 | 9 | Universal Pictures International (UPI) | false | false |
| 32 | 39 | The Class | $6,588 | +3.3% | 7 | -1 | $941 | $247,185 | 7 | Sony Pictures Releasing | false | false |
| 33 | - | Let the Right One In | $5,224 | - | 1 | - | $5,224 | $5,224 | 1 | Rialto Distribution | true | false |
| 34 | 36 | Frozen River | $5,013 | -29.5% | 3 | - | $1,671 | $26,826 | 3 | Sony Pictures Releasing | false | false |
| 35 | 32 | Madagascar: Escape 2 Africa | $2,672 | -73.1% | 9 | -9 | $296 | $15,093,421 | 13 | Paramount Pictures International | false | false |
| 36 | 42 | Fly Me to the Moon 3D | $1,822 | -50% | 2 | - | $911 | $487,430 | 25 | IMAX | false | false |
| 37 | 35 | Frost/Nixon | $1,430 | -80.6% | 13 | -12 | $110 | $1,323,648 | 11 | Universal Pictures International (UPI) | false | false |
| 38 | 58 | Under the Sea 3D | $1,240 | +309.2% | 1 | - | $1,240 | $2,100 | 2 | IMAX | false | false |
