| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Bedtime Stories | $104,267 | -44.5% | 34 | +2 | $3,066 | $628,525 | 3 | Walt Disney Pictures | false | false |
| 2 | 2 | Slumdog Millionaire | $81,037 | -19.1% | 21 | +2 | $3,858 | $336,314 | 3 | Bazuca Films | false | false |
| 3 | - | Watchmen | $73,117 | - | 36 | - | $2,031 | $73,117 | 1 | United International Pictures | true | false |
| 4 | 3 | Valkyrie | $58,210 | -31% | 41 | -1 | $1,419 | $636,897 | 4 | 20th Century Fox International | false | false |
| 5 | - | Jonas Brothers: The 3D Concert Experience | $49,720 | - | 8 | - | $6,215 | $49,720 | 1 | Walt Disney Pictures | true | false |
| 6 | 4 | The Curious Case of Benjamin Button | $36,007 | -29.8% | 27 | -4 | $1,333 | $992,796 | 7 | Warner Bros. | false | false |
| 7 | - | Impy's Island | $29,721 | - | 16 | - | $1,857 | $29,721 | 1 | Bazuca Films | true | false |
| 8 | - | Righteous Kill | $27,661 | - | 18 | - | $1,536 | $27,661 | 1 | CDI Films | true | false |
| 9 | 5 | Doubt | $22,486 | -15.1% | 7 | +1 | $3,212 | $59,735 | 2 | Walt Disney Pictures | false | false |
| 10 | 7 | Friday the 13th | $19,911 | -22.9% | 17 | - | $1,171 | $193,751 | 4 | United International Pictures | false | false |
| 11 | 8 | He's Just Not That Into You | $18,495 | -8.7% | 11 | +8 | $1,681 | $173,189 | 4 | Warner Bros. | false | false |
| 12 | 10 | The Bank Job | $10,730 | -37.6% | 12 | - | $894 | $34,990 | 2 | Transeuropa | false | false |
| 13 | 9 | Seven Pounds | $10,656 | -42% | 12 | -3 | $888 | $74,488 | 3 | Sony Pictures Releasing | false | false |
| 14 | 15 | The Duchess | $7,167 | -33.6% | 4 | -5 | $1,791 | $48,825 | 3 | United International Pictures | false | false |
| 15 | 16 | Hotel for Dogs | $7,083 | -26% | 9 | +2 | $787 | $231,470 | 7 | United International Pictures | false | false |
| 16 | 6 | Coraline | $6,834 | -74.2% | 11 | -7 | $621 | $200,784 | 5 | United International Pictures | false | false |
| 17 | 12 | Inkheart | $6,393 | -56.5% | 13 | -6 | $491 | $343,586 | 5 | Warner Bros. | false | false |
| 18 | 19 | The Strangers | $5,754 | +11.9% | 7 | +3 | $822 | $97,158 | 7 | Bazuca Films | false | false |
| 19 | 17 | Yes Man | $5,354 | -41% | 5 | -1 | $1,070 | $871,826 | 8 | Warner Bros. | false | false |
| 20 | 11 | Bolt | $4,827 | -69.3% | 12 | -4 | $402 | $1,699,540 | 11 | Walt Disney Pictures | false | false |
| 21 | 13 | Flawless | $3,872 | -66.2% | 8 | -2 | $484 | $19,270 | 2 | Bazuca Films | false | false |
| 22 | 18 | Twilight | $3,605 | -59.3% | 5 | -9 | $721 | $1,288,539 | 10 | Bazuca Films | false | false |
| 23 | 26 | The Boy in the Striped Pajamas | $3,443 | +58.7% | 4 | - | $860 | $236,690 | 8 | Walt Disney Pictures | false | false |
| 24 | 25 | Che: Part One | $2,231 | -19.1% | 1 | - | $2,231 | $117,159 | 6 | Bazuca Films | false | false |
| 25 | 22 | The Tale of Despereaux | $2,104 | -34.3% | 9 | -1 | $233 | $149,110 | 6 | United International Pictures | false | false |
| 26 | 27 | Family Hero | $1,879 | +30.5% | 1 | - | $1,879 | $23,002 | 4 | Andes Films | false | false |
| 27 | 20 | Quarantine | $1,458 | -71.3% | 3 | -3 | $486 | $188,281 | 6 | Sony Pictures Releasing | false | false |
| 28 | 14 | Rudo y Cursi | $669 | -94.1% | 3 | -28 | $223 | $17,159 | 2 | United International Pictures | false | false |
| 29 | 23 | Beverly Hills Chihuahua | $644 | -78.4% | 3 | -2 | $214 | $552,218 | 9 | Walt Disney Pictures | false | false |
| 30 | 30 | The Pink Panther 2 | $351 | +19.4% | 1 | -1 | $351 | $76,734 | 5 | Sony Pictures Releasing | false | false |
| 31 | 24 | The Women | $115 | -95.9% | 1 | -7 | $115 | $15,557 | 3 | CDI Films | false | false |
| 32 | - | Dan in Real Life | $109 | - | 1 | - | $109 | $96,830 | 13 | Bazuca Films | false | false |
