| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Slumdog Millionaire | $29,981 | -38.6% | 2 | - | $14,990 | $96,769 | 2 | ACME | false | false |
| 2 | - | Watchmen | $17,809 | - | 3 | - | $5,936 | $17,809 | 1 | Universal Pictures International (UPI) | true | false |
| 3 | 2 | Bolt | $14,139 | -29.6% | 8 | - | $1,767 | $148,018 | 4 | - | false | false |
| 4 | 4 | He's Just Not That Into You | $10,067 | -14.4% | 3 | - | $3,355 | $93,065 | 4 | Universal Pictures International (UPI) | false | false |
| 5 | 3 | The Pink Panther 2 | $7,297 | -39% | 4 | - | $1,824 | $55,781 | 3 | Universal Pictures International (UPI) | false | false |
| 6 | 5 | The International | $7,283 | -31.6% | 2 | - | $3,641 | $21,324 | 2 | Universal Pictures International (UPI) | false | false |
| 7 | 6 | The Curious Case of Benjamin Button | $6,099 | -19.4% | 4 | - | $1,524 | $141,563 | 6 | Universal Pictures International (UPI) | false | false |
| 8 | - | First Love: It's the Music! | $4,775 | - | 2 | - | $2,387 | $4,775 | 1 | ACME | true | false |
| 9 | - | The Heir Apparent: Largo Winch | $4,661 | - | 1 | - | $4,661 | $4,661 | 1 | ACME | true | false |
| 10 | 7 | Yes Man | $4,553 | -33.4% | 4 | - | $1,138 | $205,739 | 9 | Universal Pictures International (UPI) | false | false |
| 11 | 9 | Hotel for Dogs | $3,671 | -33.7% | 2 | - | $1,835 | $10,032 | 2 | Universal Pictures International (UPI) | false | false |
| 12 | 8 | My Bloody Valentine | $1,678 | -73.4% | 1 | - | $1,678 | $209,693 | 8 | ACME | false | false |
| 13 | 11 | Underworld: Rise of the Lycans | $1,409 | -60.9% | 3 | - | $469 | $62,676 | 5 | Universal Pictures International (UPI) | false | false |
| 14 | 13 | Doubt | $1,379 | -40.9% | 1 | - | $1,379 | $5,542 | 2 | Universal Pictures International (UPI) | false | false |
| 15 | 17 | Madagascar: Escape 2 Africa | $1,039 | +3.1% | 9 | - | $115 | $344,022 | 13 | Universal Pictures International (UPI) | false | false |
| 16 | 12 | Valkyrie | $629 | -73.3% | 2 | - | $314 | $52,608 | 5 | Universal Pictures International (UPI) | false | false |
| 17 | 15 | Frost/Nixon | $498 | -68.3% | 1 | - | $498 | $8,633 | 3 | Universal Pictures International (UPI) | false | false |
| 18 | 10 | The Return of the Musketeers, or The Treasures of Cardinal Mazarin | $392 | -90.7% | 3 | - | $130 | $49,162 | 4 | ACME | false | false |
