| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Bedtime Stories | $282,502 | -22.9% | 59 | -1 | $4,788 | $2,500,215 | 4 | Walt Disney Pictures | false | false |
| 2 | - | Watchmen | $153,193 | - | 59 | - | $2,596 | $153,159 | 1 | N/A | true | false |
| 3 | 6 | Slumdog Millionaire | $114,020 | +6.6% | 10 | -1 | $11,402 | $332,639 | 2 | N/A | false | false |
| 4 | 5 | The Pink Panther 2 | $110,469 | -4.7% | 49 | -6 | $2,254 | $740,720 | 3 | Sony Pictures Releasing | false | false |
| 5 | 2 | Valkyrie | $107,294 | -50.6% | 47 | -14 | $2,282 | $1,054,787 | 3 | N/A | false | false |
| 6 | - | The International | $102,453 | - | 25 | - | $4,098 | $109,735 | 1 | Sony Pictures Releasing | true | false |
| 7 | 3 | The Curious Case of Benjamin Button | $95,855 | -35.9% | 27 | -13 | $3,550 | $1,576,463 | 5 | N/A | false | false |
| 8 | - | Dan in Real Life | $93,898 | - | 27 | - | $3,477 | $93,898 | 1 | N/A | true | false |
| 9 | 4 | Yes Man | $67,562 | -49.2% | 33 | -16 | $2,047 | $3,175,227 | 7 | Warner Bros. | false | false |
| 10 | 10 | Death Sentence | $56,546 | +3% | 22 | +6 | $2,570 | $166,175 | 2 | N/A | false | false |
| 11 | 7 | Friday the 13th | $50,589 | -39.9% | 33 | +22 | $1,533 | $692,162 | 4 | N/A | false | false |
| 12 | 8 | Doubt | $47,822 | -19.6% | 17 | +1 | $2,813 | $171,961 | 2 | Walt Disney Pictures | false | false |
| 13 | 9 | Bride Wars | $30,849 | -44% | 9 | -8 | $3,427 | $943,520 | 5 | N/A | false | false |
| 14 | 15 | Vicky Cristina Barcelona | $19,257 | -27.5% | 6 | -1 | $3,209 | $189,321 | 4 | N/A | false | false |
| 15 | 14 | Hotel for Dogs | $18,099 | -32.7% | 23 | -6 | $786 | $1,127,590 | 7 | N/A | false | false |
| 16 | 11 | Over Her Dead Body | $13,661 | -66.9% | 11 | -9 | $1,241 | $262,520 | 4 | N/A | false | false |
| 17 | 13 | Wild Child | $12,822 | -52.8% | 19 | -1 | $674 | $175,588 | 3 | N/A | false | false |
| 18 | 12 | .45 | $12,336 | -58.3% | 10 | - | $1,233 | $62,157 | 2 | N/A | false | false |
| 19 | 18 | Mad Money | $8,530 | -18.2% | 5 | -5 | $1,706 | $221,415 | 6 | N/A | false | false |
| 20 | 16 | Quarantine | $4,160 | -69.4% | 7 | -3 | $594 | $296,907 | 7 | N/A | false | false |
| 21 | 19 | Changeling | $3,861 | -50.2% | 3 | -1 | $1,287 | $338,870 | 7 | N/A | false | false |
| 22 | 17 | Seven Pounds | $3,001 | -76.5% | 4 | -6 | $750 | $1,312,206 | 8 | N/A | false | false |
| 23 | 23 | Revolutionary Road | $1,327 | +179.4% | 1 | -1 | $1,327 | $224,445 | 6 | N/A | false | false |
| 24 | 22 | The Spirit | $115 | -92.3% | 1 | -5 | $115 | $144,943 | 5 | N/A | false | false |
