| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Slumdog Millionaire | $134,960 | - | 20 | - | $6,748 | $134,960 | 1 | Ster-Kinekor Pictures | true | false |
| 2 | - | Watchmen | $110,662 | - | 62 | - | $1,784 | $110,662 | 1 | Ster-Kinekor Pictures | true | false |
| 3 | 1 | The Pink Panther 2 | $96,183 | -37% | 75 | - | $1,282 | $279,228 | 2 | Ster-Kinekor Pictures | false | false |
| 4 | 2 | The Curious Case of Benjamin Button | $79,140 | -43.3% | 55 | - | $1,438 | $268,571 | 2 | NuMetro Distribution | false | false |
| 5 | 3 | He's Just Not That Into You | $58,524 | -24% | 50 | -1 | $1,170 | $522,649 | 4 | NuMetro Distribution | false | false |
| 6 | - | New in Town | $49,716 | - | 50 | - | $994 | $49,716 | 1 | NuMetro Distribution | true | false |
| 7 | 4 | Bedtime Stories | $40,306 | -21.8% | 51 | -2 | $790 | $486,354 | 6 | Ster-Kinekor Pictures | false | false |
| 8 | 5 | Bride Wars | $24,582 | -38.1% | 47 | -14 | $523 | $694,230 | 7 | NuMetro Distribution | false | false |
| 9 | 6 | Inkheart | $20,664 | -43.7% | 34 | -7 | $607 | $127,854 | 3 | NuMetro Distribution | false | false |
| 10 | 8 | Changeling | $19,152 | -40.5% | 26 | -3 | $736 | $126,901 | 3 | United International Pictures | false | false |
| 11 | 7 | Seven Pounds | $18,241 | -46.6% | 34 | -12 | $536 | $239,582 | 4 | Ster-Kinekor Pictures | false | false |
| 12 | 9 | Notorious | $14,440 | -46% | 22 | -3 | $656 | $96,064 | 3 | NuMetro Distribution | false | false |
| 13 | 11 | Transporter 3 | $9,994 | -41.4% | 25 | -11 | $399 | $694,060 | 8 | United International Pictures | false | false |
| 14 | 13 | The Secret Life of Bees | $8,847 | -31.7% | 20 | -3 | $442 | $136,847 | 5 | NuMetro Distribution | false | false |
| 15 | 17 | Mr. Bones 2: Back from the Past | $8,771 | +2.8% | 34 | +17 | $257 | $3,645,911 | 15 | United International Pictures | false | false |
| 16 | 12 | The Longshots | $8,620 | -41.2% | 17 | - | $507 | $28,582 | 2 | Ster-Kinekor Pictures | false | false |
| 17 | - | Jonas Brothers: The 3D Concert Experience | $8,175 | - | 9 | - | $908 | $8,175 | 1 | Ster-Kinekor Pictures | true | false |
| 18 | 10 | Role Models | $7,465 | -60.7% | 17 | -18 | $439 | $196,316 | 5 | United International Pictures | false | false |
| 19 | 16 | Doubt | $7,111 | -22% | 9 | -1 | $790 | $772,288 | 5 | Ster-Kinekor Pictures | false | false |
| 20 | 14 | Valkyrie | $5,788 | -49.5% | 17 | -12 | $340 | $324,914 | 6 | NuMetro Distribution | false | false |
| 21 | 15 | The Wrestler | $5,067 | -48.8% | 8 | -5 | $633 | $42,350 | 3 | United International Pictures | false | false |
| 22 | 18 | The Duchess | $4,224 | -48.4% | 9 | -2 | $469 | $127,451 | 6 | Ster-Kinekor Pictures | false | false |
| 23 | 21 | Revolutionary Road | $4,183 | -19.9% | 10 | -3 | $418 | $177,723 | 7 | United International Pictures | false | false |
| 24 | 22 | Vicky Cristina Barcelona | $3,125 | -12.1% | 3 | -4 | $1,041 | $179,797 | 10 | United International Pictures | false | false |
| 25 | 24 | Frost/Nixon | $1,226 | -44.5% | 2 | -1 | $613 | $42,757 | 6 | United International Pictures | false | false |
| 26 | 25 | Four Christmases | $1,155 | -42.6% | 5 | - | $231 | $506,618 | 9 | NuMetro Distribution | false | false |
| 27 | 23 | Burn After Reading | $590 | -79.7% | 2 | -5 | $295 | $275,367 | 9 | Ster-Kinekor Pictures | false | false |
| 28 | 27 | Appaloosa | $341 | -53.7% | 2 | -1 | $170 | $20,960 | 4 | NuMetro Distribution | false | false |
| 29 | 30 | Pride and Glory | $107 | +33.8% | 1 | - | $107 | $222,077 | 10 | NuMetro Distribution | false | false |
| 30 | 26 | Killshot | $73 | -90.1% | 1 | -2 | $73 | $90,124 | 7 | Ster-Kinekor Pictures | false | false |
