| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Race to Witch Mountain | $226,021 | - | 20 | - | $11,301 | $226,021 | 1 | N/A | true | false |
| 2 | - | Gran Torino | $145,780 | - | 19 | - | $7,672 | $145,780 | 1 | N/A | true | false |
| 3 | - | Hotel for Dogs | $123,271 | - | 19 | - | $6,487 | $123,271 | 1 | United International Pictures | true | false |
| 4 | - | Nims Bond | $90,288 | - | 14 | - | $6,449 | $90,298 | 1 | N/A | true | false |
| 5 | - | The Midnight Meat Train | $83,488 | - | 18 | - | $4,638 | $83,488 | 1 | N/A | true | false |
| 6 | 2 | Marley & Me | $65,270 | -69.5% | 12 | -7 | $5,439 | $323,910 | 2 | N/A | false | false |
| 7 | 1 | Watchmen | $58,569 | -82.9% | 24 | -16 | $2,440 | $455,000 | 2 | United International Pictures | false | false |
| 8 | 4 | Slumdog Millionaire | $41,583 | -44.3% | 11 | - | $3,780 | $1,216,212 | 8 | Gulf Film | false | false |
| 9 | 6 | The Pink Panther 2 | $24,431 | -61.9% | 5 | - | $4,886 | $813,440 | 5 | N/A | false | false |
| 10 | 3 | What Just Happened | $20,769 | -75.4% | 14 | - | $1,483 | $123,938 | 2 | Gulf Film | false | false |
| 11 | - | Finding Amanda | $12,251 | - | 6 | - | $2,041 | $12,251 | 1 | N/A | true | false |
| 12 | 7 | The Curious Case of Benjamin Button | $9,393 | -82.8% | 2 | -5 | $4,696 | $607,861 | 4 | N/A | false | false |
| 13 | 5 | The International | $9,365 | -86.7% | 2 | -9 | $4,682 | $421,084 | 3 | N/A | false | false |
| 14 | - | Bella | $5,784 | - | 4 | - | $1,446 | $5,784 | 1 | N/A | true | false |
| 15 | 10 | Confessions of a Shopaholic | $5,719 | -83.9% | 1 | -4 | $5,719 | $355,716 | 4 | N/A | false | false |
| 16 | 14 | Yes Man | $2,739 | -67.9% | 1 | - | $2,739 | $738,370 | 8 | N/A | false | false |
| 17 | 11 | Garfield's Fun Fest | $2,427 | -90.4% | 1 | -7 | $2,427 | $119,557 | 4 | N/A | false | false |
| 18 | 20 | My Mom's New Boyfriend | $2,079 | -1% | 1 | -1 | $2,079 | $160,668 | 7 | N/A | false | false |
| 19 | 18 | The Unborn | $1,781 | -36.1% | 1 | -1 | $1,781 | $511,120 | 6 | N/A | false | false |
| 20 | 17 | Madagascar: Escape 2 Africa | $1,710 | -40.4% | 1 | - | $1,710 | $1,904,454 | 16 | N/A | false | false |
| 21 | 21 | Role Models | $1,492 | -5% | 1 | -1 | $1,492 | $134,191 | 5 | N/A | false | false |
| 22 | 19 | Twilight | $1,409 | -33.9% | 1 | -1 | $1,409 | $1,253,091 | 15 | N/A | false | false |
| 23 | 8 | Day of the Dead | $916 | -98% | 3 | -14 | $305 | $223,008 | 3 | N/A | false | false |
| 24 | 13 | Penelope | $340 | -96.4% | 1 | -5 | $340 | $62,597 | 3 | N/A | false | false |
