| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Música en espera | $193,157 | - | 38 | - | $5,083 | $193,157 | 1 | Distribution Company | true | false |
| 2 | 1 | Gran Torino | $108,179 | -26.5% | 47 | - | $2,301 | $568,272 | 3 | Warner Bros. | false | false |
| 3 | - | Confessions of a Shopaholic | $100,458 | - | 46 | - | $2,183 | $100,458 | 1 | Walt Disney Pictures | true | false |
| 4 | 3 | Slumdog Millionaire | $98,083 | -25.4% | 43 | - | $2,281 | $509,306 | 6 | Distribution Company | false | false |
| 5 | 2 | He's Just Not That Into You | $87,539 | -36.7% | 31 | - | $2,823 | $509,336 | 3 | Distribution Company | false | false |
| 6 | 4 | Transporter 3 | $78,028 | -34.3% | 42 | - | $1,857 | $226,365 | 2 | - | false | false |
| 7 | 6 | Bedtime Stories | $65,742 | -27.3% | 77 | -2 | $853 | $2,007,243 | 7 | Walt Disney Pictures | false | false |
| 8 | 8 | The Curious Case of Benjamin Button | $56,694 | -27.1% | 64 | -9 | $885 | $2,001,891 | 7 | Warner Bros. | false | false |
| 9 | 5 | Gomorrah | $47,851 | -47.5% | 31 | - | $1,543 | $165,025 | 2 | Alfa Films | false | false |
| 10 | 7 | Watchmen | $45,972 | -42.5% | 56 | +10 | $820 | $381,808 | 3 | Paramount Pictures International | false | false |
| 11 | 9 | Paris | $40,553 | -35.1% | 17 | +2 | $2,385 | $119,428 | 2 | Impacto Cine | false | false |
| 12 | - | The Edge of Heaven | $38,464 | - | 13 | - | $2,958 | $38,484 | 1 | Alfa Films | true | false |
| 13 | 13 | Hotel for Dogs | $32,950 | +2.3% | 40 | +2 | $823 | $527,434 | 5 | Paramount Pictures International | false | false |
| 14 | 10 | Bride Wars | $28,593 | -39.1% | 39 | -3 | $733 | $340,752 | 4 | 20th Century Fox International | false | false |
| 15 | 11 | Coraline | $26,673 | -36.5% | 24 | +1 | $1,111 | $78,339 | 2 | Universal Pictures International (UPI) | false | false |
| 16 | 12 | Vicky Cristina Barcelona | $24,780 | -27.7% | 39 | +7 | $635 | $753,286 | 7 | Pachamama Cine | false | false |
| 17 | 14 | Seven Pounds | $17,759 | -39.7% | 23 | -3 | $772 | $222,087 | 4 | Sony Pictures Releasing | false | false |
| 18 | 16 | Friday the 13th | $13,087 | -35.5% | 30 | -5 | $436 | $367,006 | 6 | Paramount Pictures International | false | false |
| 19 | 17 | Valkyrie | $11,535 | -40.7% | 36 | -25 | $320 | $738,138 | 6 | 20th Century Fox International | false | false |
| 20 | 15 | Be Kind Rewind | $8,188 | -61.3% | 18 | - | $454 | $35,215 | 2 | Distribution Company | false | false |
| 21 | 18 | The Pink Panther 2 | $7,778 | -41.3% | 17 | -9 | $457 | $228,559 | 5 | Sony Pictures Releasing | false | false |
| 22 | 26 | Unfair Competition 2009 Re-release | $6,121 | +8.5% | 5 | - | $1,224 | $24,306 | 3 | Primer Plano Film Group | false | false |
| 23 | 19 | The Window | $5,950 | -54.3% | 9 | - | $661 | $23,597 | 2 | Distribution Company | false | false |
| 24 | 24 | Changeling | $5,582 | -20.5% | 23 | -9 | $242 | $910,272 | 9 | Universal Pictures International (UPI) | false | false |
| 25 | 34 | Death Proof | $5,546 | +467.7% | 11 | +7 | $504 | $40,162 | 4 | Pachamama Cine | false | false |
| 26 | 21 | Yes Man | $4,420 | -55.3% | 14 | -8 | $315 | $1,321,811 | 10 | Warner Bros. | false | false |
| 27 | 25 | Lovely Loneliness | $3,895 | -43.3% | 14 | +6 | $278 | $42,857 | 3 | Pachamama Cine | false | false |
| 28 | 22 | Doubt | $3,616 | -50.1% | 19 | -1 | $190 | $544,090 | 10 | Walt Disney Pictures | false | false |
| 29 | 20 | Milk | $2,969 | -72.7% | 16 | -10 | $185 | $239,717 | 6 | Universal Pictures International (UPI) | false | false |
| 30 | 27 | The Wrestler | $2,633 | -35.3% | 10 | -17 | $263 | $191,630 | 5 | Distribution Company | false | false |
| 31 | - | Hannah Montana and Miley Cyrus: Best of Both Worlds Concert | $1,985 | - | 1 | - | $1,985 | $154,932 | 29 | Walt Disney Pictures | false | false |
| 32 | 28 | Revolutionary Road | $1,424 | -41.7% | 9 | -5 | $158 | $296,378 | 8 | Paramount Pictures International | false | false |
| 33 | 49 | Madagascar: Escape 2 Africa | $1,061 | +1,584.1% | 8 | +4 | $132 | $5,230,009 | 16 | Paramount Pictures International | false | false |
| 34 | 31 | Blame it on Fidel | $872 | -39.1% | 3 | -2 | $290 | $38,561 | 9 | Zeta Films | false | false |
| 35 | 23 | The Secret Life of Bees | $787 | -88.8% | 10 | - | $78 | $10,169 | 2 | 20th Century Fox International | false | false |
| 36 | 45 | El ratón Pérez 2 | $685 | +287% | 6 | +4 | $114 | $703,719 | 12 | Walt Disney Pictures | false | false |
| 37 | 29 | Sex Drive | $583 | -67.1% | 1 | -2 | $583 | $34,790 | 8 | Alfa Films | false | false |
| 38 | 33 | Bolt | $322 | -74.9% | 8 | -3 | $40 | $2,185,326 | 10 | Walt Disney Pictures | false | false |
| 39 | 37 | The Tale of Despereaux | $317 | -49.7% | 7 | - | $45 | $181,496 | 7 | United International Pictures | false | false |
| 40 | 32 | Underworld: Rise of the Lycans | $231 | -82.3% | 3 | -2 | $77 | $374,035 | 7 | Sony Pictures Releasing | false | false |
| 41 | 43 | Am Ende kommen Touristen | $224 | -17.6% | 1 | -1 | $224 | $14,544 | 5 | Alfa Films | false | false |
| 42 | 46 | Australia | $219 | +29.6% | 2 | -1 | $109 | $818,615 | 11 | 20th Century Fox International | false | false |
| 43 | 36 | Inkheart | $169 | -81.1% | 2 | -7 | $84 | $364,924 | 8 | Distribution Company | false | false |
| 44 | - | Hielos míticos | $153 | - | 1 | - | $153 | $153 | 1 | N/A | true | false |
| 45 | 40 | L'année suivante | $112 | -79.9% | 1 | -3 | $112 | $12,627 | 4 | Zeta Films | false | false |
| 46 | - | Cartas a Malvinas | $112 | - | 1 | - | $112 | $112 | 1 | N/A | true | false |
| 47 | 44 | High School Musical 3: Senior Year | $110 | -59% | 1 | -1 | $110 | $1,314,485 | 17 | Walt Disney Pictures | false | false |
| 48 | - | The Boy in the Striped Pajamas | $108 | - | 1 | - | $108 | $86,300 | 16 | Walt Disney Pictures | false | false |
| 49 | 30 | Frost/Nixon | $50 | -97% | 1 | -3 | $50 | $43,942 | 5 | United International Pictures | false | false |
| 50 | 47 | Che: Part One | $33 | -75.2% | 1 | - | $33 | $669,305 | 19 | Alfa Films | false | false |
| 51 | 35 | Rodney | $18 | -98.1% | 1 | -3 | $18 | $6,423 | 3 | Primer Plano Film Group | false | false |
| 52 | 42 | Back to Fortin Olmos | $16 | -95.2% | 1 | - | $16 | $1,235 | 3 | Primer Plano Film Group | false | false |
