| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Underworld: Rise of the Lycans | $75,006 | - | 31 | - | $2,419 | $75,006 | 1 | Sony Pictures Releasing | true | false |
| 2 | 1 | Bedtime Stories | $68,888 | -17% | 36 | +4 | $1,913 | $813,836 | 5 | Walt Disney Pictures | false | false |
| 3 | - | Gran Torino | $57,430 | - | 15 | - | $3,828 | $65,566 | 1 | Warner Bros. | true | false |
| 4 | 2 | Slumdog Millionaire | $53,227 | -21% | 21 | +3 | $2,534 | $500,823 | 5 | Bazuca Films | false | false |
| 5 | 3 | Changeling | $43,022 | -31.6% | 33 | +1 | $1,303 | $24,133 | 2 | United International Pictures | false | false |
| 6 | 5 | Valkyrie | $22,086 | -39.6% | 31 | -4 | $712 | $724,394 | 6 | 20th Century Fox International | false | false |
| 7 | 4 | Watchmen | $20,568 | -51.5% | 36 | +1 | $571 | $177,683 | 3 | United International Pictures | false | false |
| 8 | 7 | Impy's Island | $19,245 | -19% | 15 | - | $1,283 | $80,645 | 3 | Bazuca Films | false | false |
| 9 | 6 | Jonas Brothers: The 3D Concert Experience | $18,481 | -35.9% | 8 | -1 | $2,310 | $104,347 | 3 | Walt Disney Pictures | false | false |
| 10 | 12 | He's Just Not That Into You | $15,429 | +11.7% | 9 | +1 | $1,714 | $216,313 | 6 | Warner Bros. | false | false |
| 11 | - | Descendents | $14,726 | - | 21 | - | $701 | $14,726 | 1 | N/A | true | false |
| 12 | 11 | Doubt | $9,612 | -37.9% | 6 | -1 | $1,602 | $92,698 | 4 | Walt Disney Pictures | false | false |
| 13 | 8 | The Curious Case of Benjamin Button | $9,495 | -49.6% | 14 | -9 | $678 | $1,040,859 | 9 | Warner Bros. | false | false |
| 14 | 10 | Friday the 13th | $8,784 | -44.2% | 13 | -2 | $675 | $229,988 | 6 | United International Pictures | false | false |
| 15 | - | Deception | $6,699 | - | 8 | - | $837 | $6,699 | 1 | Bazuca Films | true | false |
| 16 | 14 | Hotel for Dogs | $6,120 | -21.9% | 9 | -1 | $680 | $240,441 | 9 | United International Pictures | false | false |
| 17 | 9 | Righteous Kill | $4,980 | -68.4% | 9 | -8 | $553 | $60,788 | 3 | CDI Films | false | false |
| 18 | 18 | The Duchess | $3,666 | -22.2% | 3 | -2 | $1,222 | $61,331 | 5 | United International Pictures | false | false |
| 19 | 15 | Seven Pounds | $3,362 | -45.6% | 5 | -3 | $672 | $90,225 | 5 | Sony Pictures Releasing | false | false |
| 20 | 19 | Coraline | $3,019 | -25.8% | 9 | - | $335 | $230,412 | 7 | United International Pictures | false | false |
| 21 | 16 | The Bank Job | $2,378 | -56.3% | 5 | +2 | $475 | $48,197 | 4 | Transeuropa | false | false |
| 22 | 20 | The Boy in the Striped Pajamas | $1,992 | -42.7% | 4 | -1 | $498 | $244,300 | 10 | Walt Disney Pictures | false | false |
| 23 | 22 | Inkheart | $1,768 | -35% | 5 | -1 | $353 | $350,362 | 7 | Warner Bros. | false | false |
| 24 | 17 | The Strangers | $1,759 | -64.7% | 5 | -2 | $351 | $107,207 | 9 | Bazuca Films | false | false |
| 25 | 13 | Death Defying Acts | $1,758 | -84.7% | 6 | -6 | $293 | $16,280 | 2 | Transeuropa | false | false |
| 26 | 21 | Bolt | $1,459 | -57.5% | 9 | -1 | $162 | $1,863,499 | 13 | Walt Disney Pictures | false | false |
| 27 | 24 | Yes Man | $1,410 | -23.2% | 2 | -2 | $705 | $875,002 | 10 | Warner Bros. | false | false |
| 28 | 23 | Che: Part One | $1,220 | -40.1% | 1 | - | $1,220 | $122,063 | 8 | Bazuca Films | false | false |
| 29 | 26 | Flawless | $531 | -37.2% | 3 | - | $177 | $21,701 | 4 | Bazuca Films | false | false |
| 30 | 28 | The Tale of Despereaux | $514 | -16.2% | 2 | -1 | $257 | $158,028 | 8 | United International Pictures | false | false |
| 31 | 30 | Beverly Hills Chihuahua | $374 | -18.2% | 2 | - | $187 | $553,444 | 11 | Walt Disney Pictures | false | false |
| 32 | 29 | The Spirit | $301 | -43.8% | 1 | - | $301 | $22,575 | 9 | Sony Pictures Releasing | false | false |
| 33 | 25 | Family Hero | $285 | -79.3% | 1 | - | $285 | $25,300 | 6 | Andes Films | false | false |
| 34 | 27 | Twilight | $223 | -73.3% | 1 | -1 | $223 | $1,290,231 | 12 | Bazuca Films | false | false |
