| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Música en espera | $118,938 | -38.4% | 39 | +1 | $3,049 | $395,641 | 2 | Distribution Company | false | false |
| 2 | - | The International | $87,299 | - | 30 | - | $2,909 | $87,299 | 1 | Sony Pictures Releasing | true | false |
| 3 | 2 | Gran Torino | $73,195 | -32.3% | 51 | +4 | $1,435 | $707,734 | 4 | Warner Bros. | false | false |
| 4 | 4 | Slumdog Millionaire | $68,861 | -29.8% | 43 | - | $1,601 | $1,331,206 | 7 | Distribution Company | false | false |
| 5 | 5 | He's Just Not That Into You | $65,723 | -24.9% | 31 | - | $2,120 | $629,391 | 4 | Distribution Company | false | false |
| 6 | 3 | Confessions of a Shopaholic | $57,994 | -42.3% | 46 | - | $1,260 | $223,922 | 2 | Walt Disney Pictures | false | false |
| 7 | 6 | Transporter 3 | $42,589 | -45.4% | 42 | - | $1,014 | $316,408 | 3 | - | false | false |
| 8 | 7 | Bedtime Stories | $41,623 | -36.7% | 71 | -6 | $586 | $2,097,729 | 8 | Walt Disney Pictures | false | false |
| 9 | - | Push | $36,670 | - | 25 | - | $1,466 | $36,670 | 1 | Alfa Films | true | false |
| 10 | 8 | The Curious Case of Benjamin Button | $33,409 | -41.1% | 65 | +1 | $513 | $2,069,879 | 8 | Warner Bros. | false | false |
| 11 | 13 | Hotel for Dogs | $29,533 | -10.4% | 41 | +1 | $720 | $580,967 | 6 | Paramount Pictures International | false | false |
| 12 | 9 | Gomorrah | $24,464 | -48.9% | 33 | +2 | $741 | $216,709 | 3 | Alfa Films | false | false |
| 13 | - | Bonneville | $23,996 | - | 14 | - | $1,714 | $23,996 | 1 | Impacto Cine | true | false |
| 14 | 12 | The Edge of Heaven | $23,495 | -38.9% | 13 | - | $1,807 | $82,420 | 2 | Alfa Films | false | false |
| 15 | 11 | Paris | $21,283 | -47.5% | 16 | -1 | $1,330 | $161,600 | 3 | Impacto Cine | false | false |
| 16 | 10 | Watchmen | $21,056 | -54.2% | 41 | -15 | $513 | $431,926 | 4 | Paramount Pictures International | false | false |
| 17 | 14 | Bride Wars | $19,898 | -30.4% | 37 | -2 | $537 | $379,386 | 5 | 20th Century Fox International | false | false |
| 18 | 15 | Coraline | $19,321 | -27.6% | 24 | - | $805 | $117,913 | 3 | Universal Pictures International (UPI) | false | false |
| 19 | - | Fireflies in the Garden 2008 Re-release | $18,424 | - | 14 | - | $1,316 | $18,424 | 1 | - | true | false |
| 20 | 16 | Vicky Cristina Barcelona | $13,771 | -44.4% | 39 | - | $353 | $782,324 | 8 | Pachamama Cine | false | false |
| 21 | 17 | Seven Pounds | $11,519 | -35.1% | 16 | -7 | $719 | $244,949 | 5 | Sony Pictures Releasing | false | false |
| 22 | - | Mundo alas | $8,919 | - | 8 | - | $1,114 | $8,919 | 1 | Distribution Company | true | false |
| 23 | 20 | Be Kind Rewind | $7,308 | -10.7% | 13 | -5 | $562 | $48,454 | 3 | Distribution Company | false | false |
| 24 | 18 | Friday the 13th | $5,540 | -57.7% | 21 | -9 | $263 | $380,139 | 7 | Paramount Pictures International | false | false |
| 25 | 19 | Valkyrie | $4,529 | -60.7% | 21 | -15 | $215 | $749,513 | 7 | 20th Century Fox International | false | false |
| 26 | 35 | The Secret Life of Bees | $4,334 | +450.7% | 10 | - | $433 | $15,150 | 3 | 20th Century Fox International | false | false |
| 27 | 21 | The Pink Panther 2 | $4,145 | -46.7% | 14 | -3 | $296 | $239,270 | 6 | Sony Pictures Releasing | false | false |
| 28 | 22 | Unfair Competition 2009 Re-release | $4,133 | -32.5% | 4 | -1 | $1,033 | $32,488 | 4 | Primer Plano Film Group | false | false |
| 29 | 25 | Death Proof | $3,401 | -38.7% | 7 | -4 | $485 | $47,172 | 5 | Pachamama Cine | false | false |
| 30 | 28 | Doubt | $3,096 | -14.4% | 14 | -5 | $221 | $549,676 | 11 | Walt Disney Pictures | false | false |
| 31 | 30 | The Wrestler | $2,879 | +9.3% | 12 | +2 | $239 | $196,572 | 6 | Distribution Company | false | false |
| 32 | 23 | The Window | $2,616 | -56% | 9 | - | $290 | $30,771 | 3 | Distribution Company | false | false |
| 33 | 27 | Lovely Loneliness | $2,257 | -42.1% | 7 | -7 | $322 | $47,621 | 4 | Pachamama Cine | false | false |
| 34 | 24 | Changeling | $1,844 | -67% | 8 | -15 | $230 | $917,198 | 10 | Universal Pictures International (UPI) | false | false |
| 35 | 31 | Hannah Montana and Miley Cyrus: Best of Both Worlds Concert | $1,760 | -11.3% | 1 | - | $1,760 | $157,244 | 30 | Walt Disney Pictures | false | false |
| 36 | 32 | Revolutionary Road | $899 | -36.9% | 6 | -3 | $149 | $298,208 | 9 | Paramount Pictures International | false | false |
| 37 | 29 | Milk | $838 | -71.8% | 8 | -8 | $104 | $242,683 | 7 | Universal Pictures International (UPI) | false | false |
| 38 | - | Grace Is Gone | $827 | - | 4 | - | $206 | $827 | 1 | Distribution Company | true | false |
| 39 | 26 | Yes Man | $729 | -83.5% | 4 | -10 | $182 | $1,324,861 | 11 | Warner Bros. | false | false |
| 40 | 38 | Bolt | $581 | +80.4% | 6 | -2 | $96 | $2,186,409 | 11 | Walt Disney Pictures | false | false |
| 41 | 36 | El ratón Pérez 2 | $568 | -17.1% | 2 | -4 | $284 | $704,487 | 13 | Walt Disney Pictures | false | false |
| 42 | 40 | Underworld: Rise of the Lycans | $459 | +98.7% | 4 | +1 | $114 | $375,238 | 8 | Sony Pictures Releasing | false | false |
| 43 | 33 | Madagascar: Escape 2 Africa | $368 | -65.3% | 4 | -4 | $92 | $5,231,052 | 17 | Paramount Pictures International | false | false |
| 44 | 34 | Blame it on Fidel | $348 | -60.1% | 3 | - | $116 | $39,444 | 10 | Zeta Films | false | false |
| 45 | 44 | Hielos míticos | $197 | +28.8% | 1 | - | $197 | $529 | 2 | N/A | false | false |
| 46 | 52 | Back to Fortin Olmos | $161 | +906.2% | 2 | +1 | $80 | $1,571 | 4 | Primer Plano Film Group | false | false |
| 47 | 41 | Am Ende kommen Touristen | $148 | -33.9% | 1 | - | $148 | $14,574 | 6 | Alfa Films | false | false |
| 48 | 43 | Inkheart | $84 | -50.3% | 1 | -1 | $84 | $365,145 | 9 | Distribution Company | false | false |
| 49 | 39 | The Tale of Despereaux | $70 | -77.9% | 1 | -6 | $70 | $180,347 | 8 | United International Pictures | false | false |
| 50 | - | Aniceto | $52 | - | 1 | - | $52 | $134,481 | 42 | Primer Plano Film Group | false | false |
| 51 | - | Emma's Bliss | $43 | - | 1 | - | $43 | $26,150 | 9 | Primer Plano Film Group | false | false |
| 52 | 46 | Cartas a Malvinas | $29 | -74.1% | 1 | - | $29 | $230 | 2 | N/A | false | false |
| 53 | - | Saw V | $17 | - | 1 | - | $17 | $1,076,744 | 22 | Walt Disney Pictures | false | false |
| 54 | 49 | Frost/Nixon | $6 | -88% | 1 | - | $6 | $43,972 | 6 | United International Pictures | false | false |
