| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | 12 Rounds | $21,166 | - | 5 | - | $4,233 | $21,166 | 1 | 20th Century Fox International | true | false |
| 2 | - | Monsters vs. Aliens | $19,747 | - | 8 | - | $2,468 | $19,747 | 1 | United International Pictures | true | false |
| 3 | 1 | The Unborn | $17,717 | -34.1% | 8 | - | $2,214 | $48,923 | 2 | United International Pictures | false | false |
| 4 | 2 | The Curious Case of Benjamin Button | $16,738 | -14.6% | 8 | - | $2,092 | $338,084 | 7 | Warner Bros. | false | false |
| 5 | 3 | House | $14,135 | -24% | 4 | -1 | $3,533 | $66,289 | 3 | N/A | false | false |
| 6 | 5 | Taken | $10,677 | -24% | 3 | - | $3,559 | $123,524 | 5 | N/A | false | false |
| 7 | 4 | Outlander | $8,509 | -40.8% | 4 | -1 | $2,127 | $25,060 | 2 | - | false | false |
| 8 | - | Smother | $8,054 | - | 4 | - | $2,013 | $8,054 | 1 | - | true | false |
| 9 | 7 | Watchmen | $8,028 | -20.5% | 8 | - | $1,003 | $78,528 | 4 | United International Pictures | false | false |
| 10 | 6 | Gran Torino | $7,494 | -43.7% | 5 | - | $1,498 | $22,849 | 2 | Warner Bros. | false | false |
| 11 | 8 | Confessions of a Shopaholic | $7,056 | -26.3% | 4 | - | $1,764 | $32,854 | 3 | Walt Disney Pictures | false | false |
| 12 | 10 | Marley & Me | $5,769 | -23.8% | 2 | -1 | $2,884 | $110,224 | 5 | 20th Century Fox International | false | false |
| 13 | 9 | Hotel for Dogs | $3,916 | -48.5% | 5 | - | $783 | $25,293 | 3 | United International Pictures | false | false |
| 14 | 12 | City of Ember | $1,846 | -60.5% | 3 | - | $615 | $7,119 | 2 | - | false | false |
| 15 | 13 | Revolutionary Road | $1,490 | -61.2% | 4 | -1 | $372 | $67,657 | 6 | United International Pictures | false | false |
| 16 | - | Igor | $1,410 | - | 1 | - | $1,410 | $1,410 | 1 | N/A | true | false |
| 17 | 14 | The Pink Panther 2 | $1,167 | -68.4% | 1 | -1 | $1,167 | $145,228 | 8 | N/A | false | false |
| 18 | 11 | Race to Witch Mountain | $713 | -85.2% | 2 | -1 | $356 | $24,501 | 4 | Walt Disney Pictures | false | false |
| 19 | 15 | The Tale of Despereaux | $184 | -81.2% | 2 | -2 | $92 | $35,323 | 6 | United International Pictures | false | false |
| 20 | 17 | Seven Pounds | $124 | -70% | 1 | - | $124 | $58,645 | 6 | N/A | false | false |
