| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Bride Wars | $406,760 | - | 89 | - | $4,570 | $536,057 | 1 | Warner Bros. | true | false |
| 2 | 2 | Slumdog Millionaire | $265,122 | -6.3% | 48 | - | $5,523 | $3,697,343 | 7 | Cinéart | false | false |
| 3 | 1 | Confessions of a Shopaholic | $246,598 | -31.3% | 82 | +1 | $3,007 | $1,403,655 | 3 | Walt Disney Pictures | false | false |
| 4 | 3 | Marley & Me | $172,013 | -31.7% | 87 | - | $1,977 | $1,622,830 | 4 | Warner Bros. | false | false |
| 5 | 4 | My Bloody Valentine | $158,937 | -16.1% | 22 | - | $7,224 | $750,688 | 3 | RCV Film Distribution | false | false |
| 6 | - | The Unborn | $145,363 | - | 26 | - | $5,590 | $159,943 | 1 | Universal Pictures International (UPI) | true | false |
| 7 | 6 | Defiance | $124,783 | -11.8% | 46 | +1 | $2,712 | $337,340 | 2 | RCV Film Distribution | false | false |
| 8 | 10 | Bolt | $121,705 | +37.2% | 124 | - | $981 | $3,489,465 | 7 | Walt Disney Pictures | false | false |
| 9 | 5 | Watchmen | $119,516 | -33.1% | 82 | -4 | $1,457 | $1,430,809 | 4 | Universal Pictures International (UPI) | false | false |
| 10 | 7 | Gran Torino | $116,066 | -14.1% | 34 | - | $3,413 | $581,524 | 3 | Warner Bros. | false | false |
| 11 | 8 | Role Models | $82,842 | -35.7% | 45 | - | $1,840 | $458,345 | 3 | Universal Pictures International (UPI) | false | false |
| 12 | 12 | Hotel for Dogs | $65,540 | +28.5% | 57 | - | $1,149 | $962,211 | 6 | Universal Pictures International (UPI) | false | false |
| 13 | 13 | Frogs and Toads | $63,096 | +67.4% | 106 | - | $595 | $1,290,733 | 7 | A-Film Distribution | false | false |
| 14 | 9 | The Curious Case of Benjamin Button | $62,166 | -39.9% | 73 | -15 | $851 | $4,064,955 | 9 | Warner Bros. | false | false |
| 15 | 11 | The Duchess | $47,191 | -8.1% | 21 | - | $2,247 | $146,243 | 2 | Cinéart | false | false |
| 16 | 15 | Winter in Wartime | $34,556 | -2.5% | 48 | -5 | $719 | $8,089,289 | 18 | Benelux Film Distributors | false | false |
| 17 | 16 | Che: Part One | $31,871 | -8.4% | 11 | - | $2,897 | $82,836 | 2 | Wild Bunch Distribution | false | false |
| 18 | 20 | Milk | $21,432 | +26.3% | 21 | - | $1,020 | $555,677 | 10 | A-Film Distribution | false | false |
| 19 | 14 | Spy of Orange | $20,789 | -44.8% | 51 | -32 | $407 | $2,113,591 | 8 | A-Film Distribution | false | false |
| 20 | 21 | The Tale of Despereaux | $19,162 | +28.6% | 57 | +1 | $336 | $971,010 | 8 | Universal Pictures International (UPI) | false | false |
| 21 | 25 | Rachel Getting Married | $2,322 | +70.6% | 2 | - | $1,161 | $26,351 | 5 | Sony Pictures Releasing | false | false |
| 22 | 26 | The Pink Panther 2 | $820 | -33.8% | 1 | -1 | $820 | $369,094 | 7 | Sony Pictures Releasing | false | false |
