| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Monsters vs. Aliens | $245,475 | - | 20 | - | $12,273 | $245,475 | 1 | United International Pictures | true | false |
| 2 | - | Defiance | $188,788 | - | 20 | - | $9,439 | $188,788 | 1 | Gulf Film | true | false |
| 3 | - | 12 Rounds | $150,235 | - | 19 | - | $7,907 | $150,235 | 1 | 20th Century Fox International | true | false |
| 4 | - | It's Alive | $81,039 | - | 18 | - | $4,502 | $81,039 | 1 | N/A | true | false |
| 5 | - | New in Town | $79,605 | - | 19 | - | $4,189 | $79,605 | 1 | Gulf Film | true | false |
| 6 | 1 | Duplicity | $74,250 | -71.7% | 17 | -3 | $4,367 | $399,561 | 2 | United International Pictures | false | false |
| 7 | - | Cabaret | $47,618 | - | 13 | - | $3,662 | $47,618 | 1 | N/A | true | false |
| 8 | 2 | He's Just Not That Into You | $39,910 | -56.6% | 9 | -7 | $4,434 | $411,586 | 3 | Italian International Film | false | false |
| 9 | 5 | Hotel for Dogs | $26,151 | -58.4% | 6 | -9 | $4,358 | $333,504 | 4 | United International Pictures | false | false |
| 10 | 4 | Race to Witch Mountain | $18,940 | -71.5% | 4 | -11 | $4,735 | $497,174 | 4 | N/A | false | false |
| 11 | 3 | Friday the 13th | $10,009 | -87.6% | 6 | -14 | $1,668 | $385,957 | 3 | United International Pictures | false | false |
| 12 | 6 | Mnahy | $7,259 | -84.3% | 3 | -7 | $2,419 | $199,368 | 3 | N/A | false | false |
| 13 | 10 | Marley & Me | $5,094 | -64.7% | 1 | -2 | $5,094 | $399,539 | 5 | N/A | false | false |
| 14 | 13 | The Pink Panther 2 | $3,761 | -58.4% | 1 | - | $3,761 | $846,694 | 8 | N/A | false | false |
| 15 | 15 | Watchmen | $3,132 | -19% | 1 | - | $3,132 | $501,161 | 5 | United International Pictures | false | false |
| 16 | 12 | Nims Bond | $2,314 | -82.7% | 1 | -4 | $2,314 | $198,458 | 4 | N/A | false | false |
| 17 | 18 | What Just Happened | $1,864 | +21.4% | 1 | - | $1,864 | $139,194 | 5 | Gulf Film | false | false |
| 18 | - | Demons of Cairo | $1,421 | - | 1 | - | $1,421 | $27,361 | 2 | N/A | false | false |
| 19 | 16 | My Mom's New Boyfriend | $984 | -45.3% | 1 | - | $984 | $166,871 | 10 | N/A | false | false |
| 20 | 8 | Gran Torino | $730 | -95.6% | 1 | -5 | $730 | $263,940 | 4 | N/A | false | false |
| 21 | 19 | Twilight | $596 | -58.9% | 1 | - | $596 | $1,257,768 | 18 | N/A | false | false |
| 22 | 17 | Garfield's Fun Fest | $565 | -65.3% | 1 | - | $565 | $124,361 | 7 | N/A | false | false |
