| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Monsters vs. Aliens | $287,516 | - | 79 | - | $3,639 | $296,245 | 1 | United International Pictures | true | false |
| 2 | 2 | Underworld: Rise of the Lycans | $58,927 | +26.7% | 30 | - | $1,964 | $220,489 | 3 | Sony Pictures Releasing | false | false |
| 3 | 1 | Bedtime Stories | $48,592 | -8.7% | 35 | +2 | $1,388 | $975,309 | 7 | Walt Disney Pictures | false | false |
| 4 | 3 | Gran Torino | $43,211 | +7.5% | 13 | +2 | $3,323 | $180,623 | 3 | Warner Bros. | false | false |
| 5 | 4 | Slumdog Millionaire | $37,476 | +6.8% | 18 | -1 | $2,082 | $621,568 | 7 | Bazuca Films | false | false |
| 6 | 5 | Changeling | $29,312 | +4.8% | 33 | +3 | $888 | $208,548 | 4 | United International Pictures | false | false |
| 7 | 6 | Confessions of a Shopaholic | $28,898 | +7.5% | 21 | - | $1,376 | $63,815 | 2 | Walt Disney Pictures | false | false |
| 8 | 9 | Reincarnation 2009 Re-release | $17,343 | +54.8% | 7 | - | $2,477 | $33,875 | 2 | Andes Films | false | false |
| 9 | 10 | He's Just Not That Into You | $10,564 | -3.9% | 9 | +2 | $1,173 | $253,222 | 8 | Warner Bros. | false | false |
| 10 | 12 | Milk | $9,919 | +3.8% | 6 | - | $1,653 | $22,852 | 2 | United International Pictures | false | false |
| 11 | 11 | Valkyrie | $7,698 | -21% | 7 | -13 | $1,099 | $783,360 | 8 | 20th Century Fox International | false | false |
| 12 | 13 | Friday the 13th | $7,623 | -15.5% | 11 | -11 | $693 | $263,370 | 8 | United International Pictures | false | false |
| 13 | 15 | Doubt | $7,496 | +1.2% | 6 | - | $1,249 | $118,462 | 6 | Walt Disney Pictures | false | false |
| 14 | 7 | Impy's Island | $5,824 | -70.7% | 15 | - | $388 | $115,241 | 5 | Bazuca Films | false | false |
| 15 | 17 | The Curious Case of Benjamin Button | $5,652 | -14.2% | 6 | -6 | $942 | $1,105,758 | 11 | Warner Bros. | false | false |
| 16 | 14 | Watchmen | $5,503 | -39% | 12 | -10 | $458 | $211,576 | 5 | United International Pictures | false | false |
| 17 | 16 | Planet Terror | $4,678 | -31.3% | 6 | -4 | $779 | $14,572 | 2 | Bazuca Films | false | false |
| 18 | 20 | Righteous Kill | $3,487 | -1.8% | 4 | -4 | $871 | $73,180 | 5 | CDI Films | false | false |
| 19 | - | Frost/Nixon | $3,007 | - | 2 | - | $1,503 | $3,266 | 1 | United International Pictures | true | false |
| 20 | 21 | The Duchess | $2,881 | +2.7% | 1 | -1 | $2,881 | $71,444 | 7 | United International Pictures | false | false |
| 21 | 18 | Hotel for Dogs | $2,750 | -50.6% | 8 | - | $343 | $269,095 | 11 | United International Pictures | false | false |
| 22 | 19 | Descendents | $1,885 | -54.3% | 7 | -9 | $269 | $27,963 | 3 | N/A | false | false |
| 23 | 26 | Inkheart | $1,479 | +1.7% | 4 | - | $369 | $369,600 | 9 | Warner Bros. | false | false |
| 24 | 38 | Flawless | $1,024 | +540% | 1 | - | $1,024 | $24,243 | 6 | Bazuca Films | false | false |
| 25 | 25 | Seven Pounds | $1,010 | -38.3% | 3 | -1 | $336 | $94,190 | 7 | Sony Pictures Releasing | false | false |
| 26 | 28 | The Strangers | $733 | -20.2% | 2 | -1 | $366 | $115,005 | 11 | Bazuca Films | false | false |
| 27 | 22 | Coraline | $715 | -69.3% | 4 | -4 | $178 | $332,484 | 9 | United International Pictures | false | false |
| 28 | 8 | Jonas Brothers: The 3D Concert Experience | $706 | -94.4% | 1 | -8 | $706 | $125,550 | 5 | Walt Disney Pictures | false | false |
| 29 | 31 | Family Hero | $357 | -26.4% | 2 | - | $178 | $29,101 | 8 | Andes Films | false | false |
| 30 | 29 | The Boy in the Striped Pajamas | $356 | -51% | 1 | -1 | $356 | $259,677 | 12 | Walt Disney Pictures | false | false |
| 31 | 24 | Deception | $352 | -81% | 1 | -5 | $352 | $12,279 | 3 | Bazuca Films | false | false |
| 32 | 30 | Che: Part One | $290 | -50.4% | 2 | - | $145 | $128,625 | 10 | Bazuca Films | false | false |
| 33 | 23 | Four Minutes | $278 | -87.7% | 1 | -1 | $278 | $3,099 | 2 | Transeuropa | false | false |
| 34 | 27 | Bolt | $276 | -72.5% | 1 | -2 | $276 | $1,788,695 | 15 | Walt Disney Pictures | false | false |
| 35 | 35 | The Bank Job | $125 | -60.6% | 1 | - | $125 | $51,184 | 6 | Transeuropa | false | false |
| 36 | 36 | The Tale of Despereaux | $49 | -82.9% | 1 | -1 | $49 | $158,946 | 10 | United International Pictures | false | false |
