| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Fast & Furious | $1,209,102 | - | 96 | - | $12,594 | $1,209,102 | 1 | Universal Pictures International (UPI) | true | false |
| 2 | - | Monsters vs. Aliens | $288,043 | - | 180 | - | $1,600 | $369,566 | 1 | Universal Pictures International (UPI) | true | false |
| 3 | 1 | Bride Wars | $254,320 | -37.5% | 89 | - | $2,857 | $884,874 | 2 | Warner Bros. | false | false |
| 4 | - | The Reader | $205,850 | - | 32 | - | $6,432 | $236,315 | 1 | Benelux Film Distributors | true | false |
| 5 | 2 | Slumdog Millionaire | $168,101 | -36.6% | 48 | - | $3,502 | $3,987,458 | 8 | Cinéart | false | false |
| 6 | 3 | Confessions of a Shopaholic | $146,865 | -40.4% | 82 | - | $1,791 | $1,633,300 | 4 | Walt Disney Pictures | false | false |
| 7 | 5 | My Bloody Valentine | $91,337 | -42.5% | 26 | +4 | $3,512 | $893,137 | 4 | RCV Film Distribution | false | false |
| 8 | 6 | The Unborn | $79,096 | -45.6% | 26 | - | $3,042 | $893,137 | 2 | Universal Pictures International (UPI) | false | false |
| 9 | 4 | Marley & Me | $67,539 | -60.7% | 83 | -4 | $813 | $1,739,447 | 5 | Warner Bros. | false | false |
| 10 | 7 | Defiance | $67,485 | -45.9% | 46 | - | $1,467 | $436,832 | 3 | RCV Film Distribution | false | false |
| 11 | 10 | Gran Torino | $54,352 | -53.2% | 34 | - | $1,598 | $671,923 | 4 | Warner Bros. | false | false |
| 12 | 9 | Watchmen | $43,728 | -63.4% | 47 | -35 | $930 | $1,524,786 | 5 | Universal Pictures International (UPI) | false | false |
| 13 | 8 | Bolt | $35,979 | -70.4% | 113 | -11 | $318 | $3,577,161 | 8 | Walt Disney Pictures | false | false |
| 14 | 11 | Role Models | $26,717 | -67.7% | 27 | -18 | $989 | $509,017 | 4 | Universal Pictures International (UPI) | false | false |
| 15 | 12 | Hotel for Dogs | $23,820 | -63.7% | 59 | +2 | $403 | $1,007,930 | 7 | Universal Pictures International (UPI) | false | false |
| 16 | 15 | The Duchess | $23,387 | -50.4% | 21 | - | $1,113 | $191,965 | 3 | Cinéart | false | false |
| 17 | 14 | The Curious Case of Benjamin Button | $20,996 | -66.2% | 40 | -33 | $524 | $4,157,439 | 10 | Warner Bros. | false | false |
| 18 | 13 | Frogs and Toads | $20,939 | -66.8% | 103 | -3 | $203 | $1,337,130 | 8 | A-Film Distribution | false | false |
| 19 | 17 | Che: Part One | $16,281 | -48.9% | 11 | - | $1,480 | $111,609 | 3 | Wild Bunch Distribution | false | false |
| 20 | - | Gomorrah | $13,581 | - | 20 | - | $679 | $725,714 | 10 | Cinemien | false | false |
| 21 | - | Che: Part Two | $9,670 | - | 11 | - | $879 | $9,670 | 1 | Wild Bunch Distribution | true | false |
| 22 | 21 | Rachel Getting Married | $1,699 | -26.8% | 2 | - | $849 | $29,464 | 6 | Sony Pictures Releasing | false | false |
| 23 | - | Crepuscule | $178 | - | 2 | - | $89 | $178 | 1 | N/A | true | false |
