| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Monsters vs. Aliens | $36,291 | - | 14 | - | $2,592 | $36,291 | 1 | United International Pictures | true | false |
| 2 | 1 | Slumdog Millionaire | $31,034 | -48.7% | 8 | - | $3,879 | $216,972 | 3 | Blitz | false | false |
| 3 | 2 | Marley & Me | $16,647 | -38.8% | 6 | - | $2,774 | $59,391 | 2 | 20th Century Fox International | false | false |
| 4 | 3 | Confessions of a Shopaholic | $11,054 | -25.5% | 6 | - | $1,842 | $58,394 | 3 | Walt Disney Pictures | false | false |
| 5 | 5 | He's Just Not That Into You | $10,438 | -22.3% | 6 | - | $1,739 | $102,705 | 4 | Warner Bros. | false | false |
| 6 | 7 | The Reader | $5,304 | -40.8% | 2 | - | $2,652 | $49,655 | 4 | Cinemania Group | false | false |
| 7 | 8 | Watchmen | $5,076 | -26.9% | 4 | - | $1,269 | $34,504 | 3 | United International Pictures | false | false |
| 8 | 4 | Hotel for Dogs | $4,681 | -67.5% | 6 | -2 | $780 | $58,396 | 4 | United International Pictures | false | false |
| 9 | 10 | Inkheart | $2,580 | -46.9% | 4 | - | $645 | $10,292 | 2 | Warner Bros. | false | false |
| 10 | 12 | The International | $2,348 | -37.6% | 5 | - | $469 | $39,243 | 5 | Continental Film | false | false |
| 11 | 11 | The Unborn | $2,271 | -50.2% | 4 | -4 | $567 | $67,116 | 5 | Karantanija Film | false | false |
| 12 | 6 | The Tale of Despereaux | $2,055 | -77.8% | 6 | -4 | $342 | $160,980 | 8 | Karantanija Film | false | false |
| 13 | 13 | Twilight | $1,538 | -57.7% | 7 | - | $219 | $125,750 | 6 | N/A | false | false |
| 14 | 14 | Valkyrie | $1,497 | -57.9% | 7 | - | $213 | $939,999 | 6 | Continental Film | false | false |
| 15 | 16 | Transporter 3 | $783 | -70% | 3 | - | $261 | $21,400 | 4 | Continental Film | false | false |
