| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Monsters vs. Aliens | $245,147 | - | 97 | - | $2,527 | $245,147 | 1 | United International Pictures | true | false |
| 2 | 1 | Marley & Me | $132,111 | -22.8% | 65 | - | $2,032 | $769,910 | 3 | NuMetro Distribution | false | false |
| 3 | 2 | Race to Witch Mountain | $75,115 | -31.2% | 55 | - | $1,365 | $265,876 | 2 | Ster-Kinekor Pictures | false | false |
| 4 | 3 | Confessions of a Shopaholic | $60,667 | -8.3% | 51 | - | $1,189 | $436,165 | 4 | Ster-Kinekor Pictures | false | false |
| 5 | 4 | Slumdog Millionaire | $52,651 | -14.8% | 20 | - | $2,632 | $685,113 | 5 | Ster-Kinekor Pictures | false | false |
| 6 | 5 | Underworld: Rise of the Lycans | $43,290 | -21.5% | 35 | - | $1,236 | $144,939 | 2 | Ster-Kinekor Pictures | false | false |
| 7 | 6 | Gran Torino | $34,998 | -20.2% | 40 | - | $874 | $87,564 | 2 | NuMetro Distribution | false | false |
| 8 | - | 12 Rounds | $34,037 | - | 24 | - | $1,418 | $34,037 | 1 | NuMetro Distribution | true | false |
| 9 | 10 | The Reader | $26,124 | -10.2% | 10 | - | $2,612 | $77,915 | 2 | Ster-Kinekor Pictures | false | false |
| 10 | 9 | He's Just Not That Into You | $25,308 | -18.9% | 38 | -9 | $666 | $830,124 | 8 | NuMetro Distribution | false | false |
| 11 | - | Finding Lenny | $24,296 | - | 43 | - | $565 | $24,296 | 1 | NuMetro Distribution | true | false |
| 12 | 8 | The Curious Case of Benjamin Button | $23,991 | -25.4% | 37 | -17 | $648 | $587,665 | 6 | NuMetro Distribution | false | false |
| 13 | 7 | The Pink Panther 2 | $23,010 | -38.4% | 38 | -24 | $605 | $601,812 | 6 | Ster-Kinekor Pictures | false | false |
| 14 | 13 | Paul Blart: Mall Cop | $14,219 | -18.6% | 16 | -4 | $888 | $136,968 | 4 | Ster-Kinekor Pictures | false | false |
| 15 | 11 | Watchmen | $13,579 | -40.2% | 21 | -19 | $646 | $393,318 | 5 | Ster-Kinekor Pictures | false | false |
| 16 | - | Soul Men | $12,437 | - | 16 | - | $777 | $12,437 | 1 | Ster-Kinekor Pictures | true | false |
| 17 | 14 | Friday the 13th | $6,557 | -17.7% | 8 | - | $819 | $52,743 | 4 | United International Pictures | false | false |
| 18 | 16 | Rachel Getting Married | $5,854 | +0.4% | 7 | -2 | $836 | $58,193 | 4 | Ster-Kinekor Pictures | false | false |
| 19 | 15 | Defiance | $5,582 | -23.7% | 9 | -1 | $620 | $39,396 | 3 | United International Pictures | false | false |
| 20 | - | The Baader Meinhof Complex | $5,281 | - | 8 | - | $660 | $5,281 | 1 | United International Pictures | true | false |
| 21 | 17 | Aa Dekhen Zara | $4,555 | -19.6% | 3 | - | $1,518 | $13,499 | 2 | NuMetro Distribution | false | false |
| 22 | 20 | The Secret Life of Bees | $3,478 | -36.1% | 12 | -1 | $289 | $205,304 | 9 | NuMetro Distribution | false | false |
| 23 | 18 | Seven Pounds | $2,504 | -55.3% | 4 | -11 | $626 | $309,025 | 8 | Ster-Kinekor Pictures | false | false |
| 24 | 22 | Changeling | $2,469 | -48% | 4 | -4 | $617 | $200,290 | 7 | United International Pictures | false | false |
| 25 | - | Role Models | $1,139 | - | 2 | - | $569 | $214,599 | 9 | United International Pictures | false | false |
| 26 | 27 | Revolutionary Road | $922 | -14.8% | 3 | -2 | $307 | $218,915 | 11 | United International Pictures | false | false |
