| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Fast & Furious | $62,270 | -35.7% | 18 | - | $3,459 | $233,433 | 2 | United International Pictures | false | false |
| 2 | - | He's Just Not That Into You | $28,993 | - | 11 | - | $2,635 | $28,993 | 1 | Warner Bros. | true | false |
| 3 | 2 | Monsters vs. Aliens | $24,304 | -24.2% | 14 | - | $1,736 | $144,793 | 3 | United International Pictures | false | false |
| 4 | - | 12 Rounds | $13,444 | - | 8 | - | $1,680 | $13,444 | 1 | 20th Century Fox International | true | false |
| 5 | 4 | Duplicity | $6,816 | -35.7% | 10 | -4 | $681 | $125,595 | 4 | United International Pictures | false | false |
| 6 | 3 | Confessions of a Shopaholic | $6,126 | -61.8% | 9 | - | $680 | $30,345 | 2 | Prooptiki | false | false |
| 7 | 5 | Race to Witch Mountain | $5,684 | -14.4% | 10 | -1 | $568 | $91,839 | 4 | Walt Disney Pictures | false | false |
| 8 | - | Milk | $3,832 | - | 2 | - | $1,916 | $3,832 | 1 | N/A | true | false |
| 9 | 7 | Babylon A.D. | $3,527 | -11.1% | 8 | - | $440 | $40,432 | 3 | Alexandra Films | false | false |
| 10 | 6 | Marley & Me | $3,196 | -43.5% | 8 | - | $399 | $48,401 | 3 | 20th Century Fox International | false | false |
| 11 | 8 | Slumdog Millionaire | $1,811 | -31.3% | 6 | +1 | $301 | $187,383 | 9 | Forum Hungary | false | false |
| 12 | 13 | Fly Me to the Moon 3D | $1,686 | +23.1% | 2 | - | $843 | $140,738 | 7 | Forum Hungary | false | false |
| 13 | 10 | Gran Torino | $1,394 | -22.9% | 6 | -1 | $232 | $32,265 | 4 | Warner Bros. | false | false |
| 14 | 11 | In Bruges | $1,184 | -29.1% | 4 | - | $296 | $12,232 | 3 | Prooptiki | false | false |
| 15 | 9 | Defiance | $1,084 | -41.6% | 3 | - | $361 | $4,175 | 2 | Alexandra Films | false | false |
| 16 | 12 | Bride Wars | $617 | -56.1% | 6 | - | $102 | $72,485 | 5 | 20th Century Fox International | false | false |
| 17 | 18 | My Best Friend's Girl | $512 | -34.9% | 3 | -1 | $170 | $11,183 | 4 | Alexandra Films | false | false |
| 18 | 26 | Seven Pounds | $323 | +191% | 3 | - | $107 | $21,305 | 6 | Sony Pictures Releasing | false | false |
| 19 | 17 | Hotel for Dogs | $230 | -72.8% | 2 | -3 | $115 | $41,726 | 6 | United International Pictures | false | false |
| 20 | 20 | Inkheart | $183 | -46.3% | 5 | -1 | $36 | $48,168 | 6 | Warner Bros. | false | false |
| 21 | 25 | Madagascar: Escape 2 Africa | $143 | +2.9% | 3 | - | $47 | $260,015 | 20 | Prooptiki | false | false |
| 22 | 36 | The Unborn | $111 | +2,675% | 1 | - | $111 | $37,766 | 8 | United International Pictures | false | false |
| 23 | 30 | Revolutionary Road | $108 | +227.3% | 2 | - | $54 | $20,655 | 7 | United International Pictures | false | false |
| 24 | 21 | Push | $96 | -71.3% | 3 | -2 | $32 | $63,822 | 7 | - | false | false |
| 25 | 16 | Watchmen | $95 | -90.5% | 1 | -6 | $95 | $95,640 | 5 | United International Pictures | false | false |
| 26 | 23 | The World is Big and Salvation Lurks Around the Corner | $91 | -55.2% | 1 | - | $91 | $83,591 | 27 | Alexandra Films | false | false |
| 27 | 14 | Midsummer Madness | $89 | -92.9% | 2 | - | $44 | $1,450 | 2 | Art Fest | false | false |
| 28 | 19 | The International | $71 | -85% | 3 | -1 | $23 | $153,979 | 7 | Alexandra Films | false | false |
| 29 | 24 | The Curious Case of Benjamin Button | $45 | -75.4% | 3 | -2 | $15 | $126,171 | 8 | Warner Bros. | false | false |
| 30 | 29 | Bolt | $44 | +7.3% | 2 | -2 | $22 | $287,320 | 17 | Sunny Films | false | false |
| 31 | 31 | Kung Fu Panda | $42 | +100% | 1 | - | $42 | $196,604 | 41 | Prooptiki | false | false |
| 32 | 27 | The Tale of Despereaux | $30 | -68.4% | 3 | -2 | $10 | $79,765 | 12 | United International Pictures | false | false |
| 33 | - | Arn: The Knight Templar | $24 | - | 1 | - | $24 | $56,257 | 12 | - | false | false |
| 34 | - | Mamma Mia! | $13 | - | 1 | - | $13 | $278,025 | 32 | Prooptiki | false | false |
| 35 | - | Then She Found Me | $8 | - | 2 | - | $4 | $9,329 | 8 | Alexandra Films | false | false |
| 36 | 33 | El Greco 2008 Re-release | $7 | -50% | 1 | - | $7 | $3,393 | 11 | Prooptiki | false | false |
| 37 | 35 | Love in the Time of Cholera | $7 | -50% | 1 | - | $7 | $33,546 | 46 | Prooptiki | false | false |
| 38 | - | Role Models | $7 | - | 1 | - | $7 | $58,621 | 15 | Prooptiki | false | false |
