| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Star Trek | $3,577,705 | - | 317 | - | $11,286 | $3,599,674 | 1 | Paramount Pictures International | true | false |
| 2 | 1 | X-Men Origins: Wolverine | $2,248,707 | -53.5% | 414 | -2 | $5,431 | $9,947,149 | 2 | 20th Century Fox International | false | false |
| 3 | - | Ghosts of Girlfriends Past | $1,382,107 | - | 219 | - | $6,310 | $1,382,107 | 1 | Roadshow Films | true | false |
| 4 | 3 | Defiance | $504,809 | -31.9% | 174 | - | $2,901 | $1,628,415 | 2 | Roadshow Films | false | false |
| 5 | 2 | Fast & Furious | $434,296 | -44.9% | 303 | - | $1,433 | $12,538,559 | 5 | Universal Pictures International (UPI) | false | false |
| 6 | 5 | The Boy in the Striped Pajamas | $282,743 | -21.6% | 120 | +1 | $2,356 | $1,836,502 | 3 | Walt Disney Pictures | false | false |
| 7 | 4 | 17 Again | $210,974 | -49.3% | 180 | -37 | $1,172 | $9,397,040 | 5 | Roadshow Films | false | false |
| 8 | 6 | Monsters vs. Aliens | $179,746 | -46.4% | 199 | -68 | $903 | $15,493,521 | 6 | Paramount Pictures International | false | false |
| 9 | - | Samson & Delilah | $152,987 | - | 12 | - | $12,748 | $169,394 | 1 | Paramount Pictures International | true | false |
| 10 | 7 | The Boat That Rocked | $143,044 | -42.4% | 132 | -83 | $1,083 | $4,258,927 | 5 | Universal Pictures International (UPI) | false | false |
| 11 | 8 | Fired Up! | $76,785 | -59.9% | 101 | -27 | $760 | $959,436 | 3 | Sony Pictures Releasing | false | false |
| 12 | 11 | Mary and Max | $59,141 | -25.3% | 50 | -17 | $1,182 | $866,169 | 5 | Icon Film Distribution | false | false |
| 13 | 9 | Race to Witch Mountain | $55,583 | -65.4% | 106 | -112 | $524 | $5,322,485 | 5 | Walt Disney Pictures | false | false |
| 14 | 13 | Elegy | $50,826 | -21.8% | 40 | +7 | $1,270 | $707,595 | 5 | Hopscotch Films | false | false |
| 15 | - | The Baader Meinhof Complex | $48,063 | - | 20 | - | $2,403 | $69,074 | 1 | Icon Film Distribution | true | false |
| 16 | 16 | The Reader | $45,839 | -17.1% | 47 | - | $975 | $3,281,872 | 12 | Roadshow Films | false | false |
| 17 | 14 | Tulpan | $45,720 | -20.7% | 22 | +4 | $2,078 | $291,136 | 3 | Palace Films | false | false |
| 18 | 15 | Easy Virtue | $43,606 | -22.8% | 65 | -10 | $670 | $1,999,010 | 9 | Hopscotch Films | false | false |
| 19 | 10 | Knowing | $35,599 | -60.9% | 54 | -49 | $659 | $5,795,063 | 7 | Icon Film Distribution | false | false |
| 20 | - | Synecdoche, New York | $31,503 | - | 5 | - | $6,300 | $31,503 | 1 | Roadshow Films | true | false |
| 21 | 21 | Paris 36 | $26,023 | -12.5% | 12 | - | $2,168 | $119,531 | 2 | Sony Pictures Releasing | false | false |
| 22 | 19 | The Pink Panther 2 | $8,904 | -75.3% | 25 | -53 | $356 | $2,079,631 | 6 | Sony Pictures Releasing | false | false |
| 23 | - | Paul Blart: Mall Cop | $5,667 | - | 21 | - | $269 | $3,725,498 | 8 | Sony Pictures Releasing | false | false |
