| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Angels & Demons | $1,169,405 | - | 98 | - | $11,932 | $1,197,612 | 1 | Sony Pictures Releasing | true | false |
| 2 | 1 | X-Men Origins: Wolverine | $250,947 | -29.9% | 100 | - | $2,509 | $1,693,891 | 3 | 20th Century Fox International | false | false |
| 3 | 3 | 17 Again | $211,179 | +12% | 36 | +2 | $5,866 | $510,308 | 2 | Kinepolis Film Distribution (KFD) | false | false |
| 4 | 2 | Star Trek | $200,420 | -33.2% | 43 | - | $4,660 | $562,526 | 2 | Universal Pictures International (UPI) | false | false |
| 5 | 4 | Sister Smile | $105,942 | -8.9% | 33 | +1 | $3,210 | $320,980 | 2 | Kinepolis Film Distribution (KFD) | false | false |
| 6 | 5 | Fast & Furious | $81,527 | -19.9% | 46 | -2 | $1,772 | $3,082,338 | 6 | Universal Pictures International (UPI) | false | false |
| 7 | 6 | He's Just Not That Into You | $80,519 | -20.1% | 29 | -7 | $2,776 | $858,993 | 4 | Paradiso Entertainment | false | false |
| 8 | 7 | My Bloody Valentine | $71,918 | -24.7% | 15 | - | $4,794 | $331,425 | 3 | Kinepolis Film Distribution (KFD) | false | false |
| 9 | 14 | Beverly Hills Chihuahua | $68,297 | +69.6% | 44 | -7 | $1,552 | $1,062,641 | 7 | Walt Disney Pictures | false | false |
| 10 | 12 | Monsters vs. Aliens | $64,306 | +40.7% | 69 | -6 | $931 | $1,544,425 | 7 | Universal Pictures International (UPI) | false | false |
| 11 | 9 | Coco Before Chanel | $61,107 | -14.3% | 31 | -1 | $1,971 | $491,698 | 4 | Kinepolis Film Distribution (KFD) | false | false |
| 12 | 8 | Knowing | $59,207 | -33.1% | 33 | -8 | $1,794 | $2,426,778 | 7 | Belga Films | false | false |
| 13 | 10 | Incognito | $46,327 | -7.4% | 14 | - | $3,309 | $219,043 | 3 | Alternative Films | false | false |
| 14 | 11 | OSS 117: Lost in Rio | $43,921 | -9.9% | 20 | -1 | $2,196 | $684,955 | 5 | Belga Films | false | false |
| 15 | 17 | Je l'aimais | $35,913 | +35.8% | 11 | -1 | $3,264 | $85,032 | 2 | N/A | false | false |
| 16 | 13 | Slumdog Millionaire | $33,145 | -23.5% | 32 | -5 | $1,035 | $3,546,029 | 18 | Cinéart | false | false |
| 17 | 15 | The Last House on the Left | $27,536 | -24.6% | 17 | -6 | $1,619 | $291,427 | 4 | Universal Pictures International (UPI) | false | false |
| 18 | 18 | In the Electric Mist | $19,096 | -11.5% | 13 | - | $1,468 | $208,404 | 4 | Benelux Film Distributors | false | false |
| 19 | 20 | The Boy in the Striped Pajamas | $17,886 | +0.6% | 11 | - | $1,626 | $90,279 | 3 | Walt Disney Pictures | false | false |
| 20 | 19 | S&M Judge | $16,374 | -20.4% | 14 | -1 | $1,169 | $1,047,476 | 10 | Kinepolis Film Distribution (KFD) | false | false |
| 21 | - | Observe and Report | $13,108 | - | 6 | - | $2,184 | $13,404 | 1 | 20th Century Fox International | true | false |
| 22 | 21 | London River | $10,070 | -7.9% | 11 | -1 | $915 | $53,367 | 3 | ABC Distribution | false | false |
| 23 | 29 | Bolt | $9,812 | +76.1% | 12 | -15 | $817 | $3,143,980 | 14 | Walt Disney Pictures | false | false |
| 24 | 16 | The Boat That Rocked | $9,719 | -66.4% | 17 | -11 | $571 | $64,127 | 2 | Universal Pictures International (UPI) | false | false |
| 25 | 27 | Gran Torino | $9,686 | +38.2% | 10 | - | $968 | $1,117,636 | 12 | Warner Bros. | false | false |
| 26 | - | Jonas Brothers: The 3D Concert Experience | $8,046 | - | 12 | - | $670 | $8,046 | 1 | Walt Disney Pictures | true | false |
| 27 | - | Romaine 30° Below | $7,879 | - | 3 | - | $2,626 | $8,323 | 1 | Les Films de l'Elysée | true | false |
| 28 | 22 | Duplicity | $7,444 | -30.6% | 5 | -4 | $1,488 | $906,460 | 8 | Universal Pictures International (UPI) | false | false |
| 29 | 25 | The Reader | $6,987 | -5.5% | 13 | - | $537 | $829,105 | 11 | Benelux Film Distributors | false | false |
| 30 | 32 | Ponyo | $6,983 | +112.4% | 9 | +1 | $775 | $92,261 | 6 | Cinéart | false | false |
| 31 | 23 | Make It Happen | $6,714 | -32% | 15 | - | $447 | $323,261 | 6 | Benelux Film Distributors | false | false |
| 32 | 28 | Safari | $6,509 | +1.6% | 10 | -2 | $650 | $535,499 | 7 | Alternative Films | false | false |
| 33 | 24 | The Chaser | $6,286 | -23.9% | 5 | - | $1,257 | $25,403 | 2 | Cinéart | false | false |
| 34 | - | Synecdoche, New York | $5,417 | - | 4 | - | $1,354 | $6,142 | 1 | Paradiso Entertainment | true | false |
| 35 | 26 | Chéri | $5,375 | -24.5% | 10 | - | $537 | $241,712 | 6 | Benelux Film Distributors | false | false |
| 36 | 37 | Katanga Business | $3,902 | +69.4% | 7 | - | $557 | $96,126 | 7 | Cinéart | false | false |
| 37 | 40 | Hotel for Dogs | $3,439 | +86.8% | 13 | -2 | $264 | $1,235,757 | 13 | Universal Pictures International (UPI) | false | false |
| 38 | 47 | Linha de Passe | $3,363 | +363.2% | 5 | - | $672 | $45,018 | 5 | Cinéart | false | false |
| 39 | 38 | Milk | $2,442 | +6.4% | 9 | - | $271 | $376,401 | 12 | A-Film Distribution | false | false |
| 40 | 36 | Frozen River | $2,431 | -3.9% | 4 | - | $607 | $25,850 | 5 | A-Film Distribution | false | false |
| 41 | 33 | Welcome | $2,163 | -29.2% | 6 | -2 | $360 | $169,847 | 8 | Cinéart | false | false |
| 42 | 35 | The International | $2,049 | -27% | 2 | -1 | $1,024 | $355,898 | 10 | Sony Pictures Releasing | false | false |
| 43 | 42 | Confessions of a Shopaholic | $1,807 | +13.7% | 2 | -7 | $903 | $923,595 | 9 | Walt Disney Pictures | false | false |
| 44 | - | Episode 3: 'Enjoy Poverty' | $1,660 | - | 2 | - | $830 | $1,660 | 1 | N/A | true | false |
| 45 | 30 | Le missionnaire | $1,530 | -67% | 4 | -7 | $382 | $35,165 | 3 | N/A | false | false |
| 46 | 41 | The Uninvited | $1,314 | -18.9% | 1 | -1 | $1,314 | $164,844 | 5 | Universal Pictures International (UPI) | false | false |
| 47 | 43 | The Unborn | $1,273 | +9.4% | 2 | -2 | $636 | $288,914 | 9 | Universal Pictures International (UPI) | false | false |
| 48 | 31 | Defiance | $1,272 | -63.2% | 2 | -2 | $636 | $265,967 | 11 | Kinepolis Film Distribution (KFD) | false | false |
| 49 | 49 | Inkheart | $1,055 | +111% | 3 | +1 | $351 | $105,975 | 6 | Paradiso Entertainment | false | false |
| 50 | 51 | Twilight | $508 | +19.2% | 1 | - | $508 | $3,445,614 | 25 | Belga Films | false | false |
