| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Angels & Demons | $59,725 | - | 8 | - | $7,465 | $59,725 | 1 | Sony Pictures Releasing | true | false |
| 2 | 2 | Knowing | $19,632 | -36% | 8 | - | $2,454 | $197,412 | 4 | - | false | false |
| 3 | 1 | X-Men Origins: Wolverine | $19,378 | -39.9% | 8 | - | $2,422 | $117,331 | 3 | 20th Century Fox International | false | false |
| 4 | 3 | Duplicity | $17,898 | -34.6% | 8 | - | $2,237 | $49,576 | 2 | United International Pictures | false | false |
| 5 | - | Star Trek | $15,164 | - | 5 | - | $3,032 | $15,164 | 1 | United International Pictures | true | false |
| 6 | 5 | The Uninvited | $9,292 | -32.2% | 8 | - | $1,161 | $51,481 | 3 | United International Pictures | false | false |
| 7 | 6 | Fast & Furious | $6,247 | -40% | 8 | - | $780 | $236,428 | 6 | United International Pictures | false | false |
| 8 | 4 | It's Alive | $3,958 | -73% | 4 | -1 | $989 | $20,912 | 2 | N/A | false | false |
| 9 | 10 | Hannah Montana: The Movie | $3,504 | -31.3% | 4 | - | $876 | $62,963 | 6 | Walt Disney Pictures | false | false |
| 10 | 7 | Friday the 13th | $3,353 | -55.5% | 7 | -1 | $479 | $52,428 | 4 | United International Pictures | false | false |
| 11 | 8 | Push | $2,952 | -58.2% | 5 | - | $590 | $69,283 | 6 | - | false | false |
| 12 | 9 | Paul Blart: Mall Cop | $2,738 | -60.8% | 4 | -3 | $684 | $75,113 | 5 | Sony Pictures Releasing | false | false |
| 13 | 11 | House | $2,031 | -53.3% | 3 | - | $677 | $127,628 | 9 | N/A | false | false |
| 14 | 13 | The Curious Case of Benjamin Button | $1,770 | -50.3% | 3 | - | $590 | $384,207 | 13 | Warner Bros. | false | false |
| 15 | 15 | Taken | $1,163 | -63.4% | 2 | - | $581 | $164,076 | 11 | N/A | false | false |
| 16 | 16 | 12 Rounds | $1,009 | -47.9% | 3 | -1 | $336 | $73,846 | 7 | 20th Century Fox International | false | false |
| 17 | 12 | Crossing Over | $874 | -79.4% | 2 | -2 | $437 | $45,557 | 5 | N/A | false | false |
| 18 | 14 | The Unborn | $873 | -72.7% | 3 | -2 | $291 | $110,511 | 8 | United International Pictures | false | false |
| 19 | 19 | Monsters vs. Aliens | $559 | -37.4% | 2 | - | $279 | $57,227 | 7 | United International Pictures | false | false |
| 20 | 18 | Dragonball Evolution | $553 | -43.4% | 3 | +1 | $184 | $16,712 | 5 | 20th Century Fox International | false | false |
| 21 | - | WALL·E | $174 | - | 1 | - | $174 | $37,253 | 41 | Walt Disney Pictures | false | false |
