| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Star Trek | $410,007 | - | 76 | - | $5,394 | $421,867 | 1 | Universal Pictures International (UPI) | true | false |
| 2 | 1 | X-Men Origins: Wolverine | $374,593 | -52.2% | 103 | - | $3,636 | $1,863,318 | 2 | Warner Bros. | false | false |
| 3 | 2 | 17 Again | $205,534 | -30.3% | 70 | - | $2,936 | $1,389,435 | 3 | RCV Film Distribution | false | false |
| 4 | 3 | He's Just Not That Into You | $147,778 | -23.5% | 85 | -1 | $1,738 | $1,369,016 | 4 | Paradiso Entertainment | false | false |
| 5 | 5 | Knowing | $111,234 | -26% | 58 | +1 | $1,917 | $1,317,268 | 5 | Independent Films | false | false |
| 6 | 6 | Monsters vs. Aliens | $101,738 | -28.2% | 119 | -7 | $854 | $1,807,752 | 6 | Universal Pictures International (UPI) | false | false |
| 7 | 7 | The Reader | $98,298 | -14.5% | 35 | - | $2,808 | $1,318,607 | 6 | Benelux Film Distributors | false | false |
| 8 | 4 | Fast & Furious | $86,038 | -50.3% | 93 | -3 | $925 | $3,549,762 | 6 | Universal Pictures International (UPI) | false | false |
| 9 | 9 | Beverly Hills Chihuahua | $80,862 | -3.4% | 59 | +1 | $1,370 | $557,821 | 3 | Walt Disney Pictures | false | false |
| 10 | 8 | Slumdog Millionaire | $71,610 | -18.9% | 48 | +2 | $1,491 | $4,750,846 | 13 | Cinéart | false | false |
| 11 | - | The Last Days of Emma Blank | $60,316 | - | 22 | - | $2,741 | $62,398 | 1 | A-Film Distribution | true | false |
| 12 | 10 | The Haunting in Connecticut | $58,562 | -25.7% | 22 | - | $2,661 | $187,955 | 2 | Benelux Film Distributors | false | false |
| 13 | 12 | Lemo | $45,165 | -11.2% | 105 | -1 | $430 | $569,951 | 5 | Independent Films | false | false |
| 14 | - | Street Fighter: The Legend of Chun-Li | $34,582 | - | 15 | - | $2,305 | $61,500 | 1 | Independent Films | true | false |
| 15 | 11 | The International | $32,723 | -47.3% | 32 | -8 | $1,022 | $427,019 | 4 | Sony Pictures Releasing | false | false |
| 16 | - | Hotel for Dogs | $19,507 | - | 37 | - | $527 | $1,183,198 | 12 | Universal Pictures International (UPI) | false | false |
| 17 | 18 | My Dad's a Detective | $15,700 | -17.6% | 39 | -2 | $402 | $188,552 | 5 | RCV Film Distribution | false | false |
| 18 | 13 | Bride Wars | $15,116 | -53.2% | 32 | -27 | $472 | $1,512,958 | 7 | Warner Bros. | false | false |
| 19 | 15 | My Bloody Valentine | $14,907 | -39.6% | 12 | -6 | $1,242 | $1,175,804 | 9 | RCV Film Distribution | false | false |
| 20 | - | Gran Torino | $12,503 | - | 13 | - | $961 | $827,018 | 9 | Warner Bros. | false | false |
