| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Angels & Demons | $497,984 | - | 52 | - | $9,576 | $497,984 | 1 | Sony Pictures Releasing | true | false |
| 2 | 3 | Hannah Montana: The Movie | $142,946 | +16.4% | 26 | - | $5,497 | $356,412 | 2 | Walt Disney Pictures | false | false |
| 3 | - | Ghosts of Girlfriends Past | $93,568 | - | 22 | - | $4,253 | $93,568 | 1 | Warner Bros. | true | false |
| 4 | 1 | Star Trek | $89,344 | -44.4% | 40 | - | $2,233 | $331,021 | 2 | Paramount Pictures International | false | false |
| 5 | 2 | X-Men Origins: Wolverine | $73,298 | -44.7% | 60 | - | $1,221 | $813,101 | 3 | 20th Century Fox International | false | false |
| 6 | 4 | My Bloody Valentine | $43,763 | -41.9% | 25 | - | $1,750 | $414,781 | 3 | N/A | false | false |
| 7 | 5 | 17 Again | $22,084 | -58.6% | 20 | - | $1,104 | $253,469 | 3 | Warner Bros. | false | false |
| 8 | 7 | Paul Blart: Mall Cop | $13,893 | -58.3% | 9 | -23 | $1,543 | $377,803 | 4 | Sony Pictures Releasing | false | false |
| 9 | 13 | Monsters vs. Aliens | $13,604 | +112.7% | 48 | - | $283 | $957,176 | 7 | Paramount Pictures International | false | false |
| 10 | 6 | Flawless | $10,492 | -69% | 12 | - | $874 | $62,354 | 2 | N/A | false | false |
| 11 | 10 | Unrest 2009 Re-release | $10,461 | -49.9% | 20 | - | $523 | $316,285 | 5 | N/A | false | false |
| 12 | 9 | Race to Witch Mountain | $10,020 | -53.4% | 36 | - | $278 | $861,331 | 6 | Walt Disney Pictures | false | false |
| 13 | 8 | The Prize | $7,377 | -68.3% | 20 | - | $368 | $105,989 | 3 | N/A | false | false |
| 14 | - | Swing Vote | $6,435 | - | 12 | - | $536 | $58,575 | 7 | N/A | false | false |
| 15 | 12 | Earth | $5,237 | -22.1% | 8 | - | $654 | $97,689 | 4 | Walt Disney Pictures | false | false |
| 16 | - | Confessions of a Shopaholic | $4,556 | - | 24 | - | $189 | $220,387 | 8 | Walt Disney Pictures | false | false |
| 17 | 14 | Space Chimps | $3,346 | -32.5% | 25 | - | $133 | $206,758 | 12 | N/A | false | false |
| 18 | - | The Return | $3,268 | - | 10 | - | $326 | $65,048 | 23 | N/A | false | false |
| 19 | - | Wild Child | $3,063 | - | 12 | - | $255 | $68,848 | 12 | Universal Pictures International (UPI) | false | false |
| 20 | 11 | The Counterfeiters | $3,053 | -60.3% | 7 | - | $436 | $39,457 | 3 | N/A | false | false |
| 21 | - | Role Models | $2,842 | - | 24 | - | $118 | $74,815 | 5 | Universal Pictures International (UPI) | false | false |
| 22 | - | The Ugly Duckling and Me! | $851 | - | 20 | - | $42 | $116,346 | 10 | N/A | false | false |
| 23 | 15 | Fast & Furious | $416 | -86% | 25 | - | $16 | $633,388 | 7 | Universal Pictures International (UPI) | false | false |
