| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Night at the Museum: Battle of the Smithsonian | $3,702,697 | - | 397 | - | $9,326 | $3,716,934 | 1 | 20th Century Fox International | true | false |
| 2 | 1 | Angels & Demons | $2,676,206 | -31.3% | 434 | - | $6,166 | $8,171,235 | 2 | Sony Pictures Releasing | false | false |
| 3 | 2 | Star Trek | $1,544,632 | -24.1% | 302 | -15 | $5,114 | $9,180,234 | 3 | Paramount Pictures International | false | false |
| 4 | 3 | X-Men Origins: Wolverine | $809,068 | -32.5% | 280 | -46 | $2,889 | $13,220,183 | 4 | 20th Century Fox International | false | false |
| 5 | 4 | Ghosts of Girlfriends Past | $654,344 | -29.7% | 218 | -1 | $3,001 | $3,845,958 | 3 | Roadshow Films | false | false |
| 6 | 5 | Observe and Report | $217,109 | -36.2% | 130 | - | $1,670 | $723,397 | 2 | Warner Bros. | false | false |
| 7 | 6 | Defiance | $211,546 | -28.8% | 138 | -36 | $1,532 | $2,507,481 | 4 | Roadshow Films | false | false |
| 8 | 9 | Samson & Delilah | $182,127 | +16.9% | 16 | -16 | $11,382 | $646,607 | 3 | Paramount Pictures International | false | false |
| 9 | 8 | The Boy in the Striped Pajamas | $145,381 | -22.6% | 104 | -16 | $1,397 | $2,437,084 | 5 | Walt Disney Pictures | false | false |
| 10 | - | What Just Happened | $140,658 | - | 35 | - | $4,018 | $140,658 | 1 | Hopscotch Films | true | false |
| 11 | 7 | Fast & Furious | $102,306 | -50.6% | 101 | -80 | $1,012 | $13,291,232 | 7 | Universal Pictures International (UPI) | false | false |
| 12 | - | Children of Winter | $79,346 | - | 2 | - | $39,673 | $90,434 | 1 | - | true | false |
| 13 | 13 | Gomorrah | $71,665 | -2.1% | 15 | - | $4,777 | $187,365 | 2 | Madman Entertainment | false | false |
| 14 | 12 | Monsters vs. Aliens | $53,071 | -37.3% | 83 | -42 | $639 | $15,983,222 | 8 | Paramount Pictures International | false | false |
| 15 | - | Vampire Killers | $53,011 | - | 40 | - | $1,325 | $53,011 | 1 | Paramount Pictures International | true | false |
| 16 | 10 | 17 Again | $40,781 | -64.4% | 76 | -61 | $536 | $9,817,556 | 7 | Roadshow Films | false | false |
| 17 | - | My Year Without Sex | $32,412 | - | 20 | - | $1,620 | $32,412 | 1 | Paramount Pictures International | true | false |
| 18 | 15 | Mary and Max | $32,392 | -27.3% | 36 | -4 | $899 | $1,004,379 | 7 | Icon Film Distribution | false | false |
| 19 | - | The Reader | $30,894 | - | 34 | - | $908 | $3,436,114 | 14 | Roadshow Films | false | false |
| 20 | 17 | The Baader Meinhof Complex | $30,164 | -6.9% | 17 | -3 | $1,774 | $170,077 | 3 | Icon Film Distribution | false | false |
| 21 | 24 | Quiet Chaos | $26,973 | +515.5% | 12 | +1 | $2,247 | $26,973 | 2 | Sharmill Films | false | false |
| 22 | - | The Voyage That Shook the World | $8,708 | - | 7 | - | $1,244 | $8,708 | 1 | - | true | false |
| 23 | - | The Chifleys of Busby Street | $2,941 | - | 3 | - | $980 | $2,941 | 1 | Ronin Films | true | false |
| 24 | - | The Alps | $484 | - | 1 | - | $484 | $484 | - | IMAX | - | false |
| 25 | - | RiP: A Remix Manifesto | $419 | - | 1 | - | $419 | $419 | 1 | Gil Scrine Films | true | false |
